Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey.

BACKGROUND Whether pet-keeping early in life protects against or promotes allergy remains unclear. OBJECTIVE Our aim was to examine the effects of childhood pet-keeping on adult allergic disease in a large international population-based study, including information on sensitization, adult pet-keeping, and pet prevalence in the populations. METHODS We used information from structured interviews (n = 18,530) and specific IgE to common aeroallergens in blood samples (n = 13,932) from participants in the European Community Respiratory Health Survey (ECRHS) to analyze the associations between keeping pets and adult asthma and hay fever. RESULTS Keeping cats in childhood was associated with asthma only among atopic subjects, an association that varied between centers (P =.002) and was stronger where cats where less common (< 40% cats: odds ratio(wheeze) [OR(wheeze)] = 1.84, 95% CI = 1.31-2.57; 40%-60% cats: OR(wheeze) = 1.33, 95% CI = 1.10-1.61; > or =60% cats: OR(wheeze) = 0.98, 95% CI = 0.73-1.33). Dogs owned in childhood or adulthood were associated with asthma among nonatopic subjects (childhood: OR(wheeze) = 1.28, 95% CI = 1.13-1.46; adulthood: OR(wheeze) = 1.31, 95% CI = 1.14-1.51; both: OR(wheeze) = 1.69, 95% CI = 1.40-2.04). In atopic subjects, those who had owned dogs in childhood had less hay fever (OR = 0.85; 95% CI = 0.73-0.98) and no increased risk of asthma (OR(wheeze) = 1.01, 95% CI = 0.87-1.17). Respiratory symptoms were more common in subjects who had owned birds during childhood (OR(wheeze) = 1.12; 95% CI = 1.02-1.23) independent of sensitization. CONCLUSIONS The effects of pet-keeping in childhood varied according to the type of pet, the allergic sensitization of the individual, and the wider environmental exposure to allergen. Cats owned in childhood were associated with more asthma in sensitized adults who grew up in areas with a low community prevalence of cats. Dogs owned in childhood seemed to protect against adult allergic disease but promote nonallergic asthma.

[1]  D. Jarvis,et al.  The European Community Respiratory Health Survey II , 1994, European Respiratory Journal.

[2]  J. Celedón,et al.  A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. , 2002, The Journal of allergy and clinical immunology.

[3]  H. Wichmann,et al.  House dust endotoxin and allergic sensitization in children. , 2002, American journal of respiratory and critical care medicine.

[4]  H. Wichmann,et al.  Exposure to pets and allergies in children , 2002, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[5]  D. Nowak,et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. , 2002, The New England journal of medicine.

[6]  J. Celedón,et al.  Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life , 2002, The Lancet.

[7]  T. Platts-Mills,et al.  Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. , 2002, American journal of respiratory and critical care medicine.

[8]  E. Peterson,et al.  Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. , 2002, JAMA.

[9]  F. Martinez,et al.  Review article CD14: an example of gene by environment interaction in allergic disease , 2002, Allergy.

[10]  B. Brunekreef,et al.  Early, current and past pet ownership: associations with sensitization, bronchial responsiveness and allergic symptoms in school children , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[11]  J. Douwes,et al.  Does environmental endotoxin exposure prevent asthma? , 2002, Thorax.

[12]  J. Douwes,et al.  Pets and vermin are associated with high endotoxin levels in house dust , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  C. Braun-Fahrländer,et al.  The role of the farm environment and animal contact for the development of asthma and allergies , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[14]  S. L. Prescott,et al.  Cord blood memory responses: are we being naïve? , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[15]  A. Woodcock,et al.  Decreased prevalence of sensitization to cats with high exposure to cat allergen. , 2001, The Journal of allergy and clinical immunology.

[16]  J. Castro‐Rodriguez,et al.  Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. , 2001, The Journal of allergy and clinical immunology.

[17]  T. Platts-Mills,et al.  Allergen exposure and the development of asthma. , 2001, Thorax.

[18]  H. Wichmann,et al.  Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group. , 2001, The European respiratory journal.

[19]  J. Debruyne,et al.  Toxocara seroprevalence and childhood asthma among Malaysian children , 2001, Pediatrics international : official journal of the Japan Pediatric Society.

[20]  N. Åberg,et al.  Allergic rhinoconjunctivitis, eczema, and sensitization in two areas with differing climates , 2001, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[21]  N. Kolstrup,et al.  Asthma and indoor environment in Nepal , 2001, Thorax.

[22]  B. Danuser,et al.  Respiratory symptoms in European animal farmers. , 2001, The European respiratory journal.

[23]  P. Nafstad,et al.  Exposure to pets and atopy‐related diseases in the first 4 years of life , 2001, Allergy.

[24]  T. Platts-Mills,et al.  Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study , 2001, The Lancet.

[25]  B. Apelberg,et al.  Systematic review: Exposure to pets and risk of asthma and asthma-like symptoms. , 2001, The Journal of allergy and clinical immunology.

[26]  T. Platts-Mills,et al.  Incidence and remission of asthma in schoolchildren: report from the obstructive lung disease in northern Sweden studies. , 2001, Pediatrics.

[27]  T. Holmen,et al.  Sensitization and exposure to pet allergens in asthmatics versus non-asthmatics with allergic rhinitis. , 2001, Respiratory medicine.

[28]  B. Björkstén,et al.  Atopy among schoolchildren in northern and southern Sweden in relation to pet ownership and early life events , 2001, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[29]  B. Niggemann,et al.  Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study , 2000, The Lancet.

[30]  J. Douwes,et al.  Is allergen exposure the major primary cause of asthma? , 2000, Thorax.

[31]  S. Bonini,et al.  Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study , 2000, BMJ : British Medical Journal.

[32]  U Ackermann-Liebrich,et al.  Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey. , 1999, The Journal of allergy and clinical immunology.

[33]  P. Holt,et al.  Role of microbial burden in aetiology of allergy and asthma , 1999, The Lancet.

[34]  N. Åberg,et al.  Does early exposure to cat or dog protect against later allergy development? , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[35]  P. Sly,et al.  Microbial stimulation as an aetiologic factor in atopic disease , 1999, Allergy.

[36]  D. Jarvis,et al.  Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. , 1999, The Journal of allergy and clinical immunology.

[37]  M. Chan-yeung,et al.  Exposure and sensitization to cat dander: asthma and asthma-like symptoms among adults. , 1999, The Journal of allergy and clinical immunology.

[38]  G. Nelson,et al.  Respiratory health and immunological profile of poultry workers. , 1998, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[39]  S. Holgate,et al.  The natural history of respiratory symptoms in a cohort of adolescents. , 1998, American Journal of Respiratory and Critical Care Medicine.

[40]  S. H. Arshad,et al.  The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. , 1998, The Journal of allergy and clinical immunology.

[41]  M. Kogevinas,et al.  Risk factors for asthma in young adults. Spanish Group of the European Community Respiratory Health Survey. , 1997, The European respiratory journal.

[42]  J. Tan,et al.  Human zoonotic infections transmitted by dogs and cats. , 1997, Archives of internal medicine.

[43]  S. Lau,et al.  Indoor allergen exposure is a risk factor for sensitization during the first three years of life. , 1997, The Journal of allergy and clinical immunology.

[44]  D. Jarvis,et al.  The distribution of total and specific serum IgE in the European Community Respiratory Health Survey. , 1997, The Journal of allergy and clinical immunology.

[45]  H. Savelkoul,et al.  Toxocara-induced eosinophilic inflammation. Airway function and effect of anti-IL-5. , 1995, American journal of respiratory and critical care medicine.

[46]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[47]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[48]  Copperman Sm.  Cherchez le chien: household pets as reservoirs of persistent or recurrent streptococcal sore throats in children. , 1982 .

[49]  Great Britain. Foreign Office.,et al.  Classification of occupations , 1960 .