Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts.

The 3' untranslated region (3' UTR) can control gene expression by affecting the localization, stability and translation of mRNAs. The recent finding that 3' UTRs can control the decapping rate of mRNAs, in combination with their ability to influence the initiation of translation, suggests that 3' UTRs act through a direct or indirect interaction between the 3' and 5' ends of mRNAs.

[1]  J. Richter,et al.  Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element. , 1989, Genes & development.

[2]  T. Hunt,et al.  Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region. , 1990, Genes & development.

[3]  M. Mittag,et al.  Circadian expression of the luciferin-binding protein correlates with the binding of a protein to the 3' untranslated region of its mRNA. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Rickles,et al.  Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes. , 1989, Genes & development.

[5]  Isoform-specific 3'-untranslated sequences sort alpha-cardiac and beta- cytoplasmic actin messenger RNAs to different cytoplasmic compartments [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 2):following 1907] , 1993, The Journal of cell biology.

[6]  T. C. Evans,et al.  Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo , 1994, Cell.

[7]  E V Koonin,et al.  New genes in old sequence: a strategy for finding genes in the bacterial genome. , 1994, Trends in biochemical sciences.

[8]  R Parker,et al.  Mechanisms of mRNA degradation in eukaryotes. , 1994, Trends in biochemical sciences.

[9]  G. Struhl,et al.  Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos , 1988, Nature.

[10]  R Parker,et al.  Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. , 1994, Genes & development.

[11]  M. Wickens,et al.  Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU. , 1989, Genes & development.

[12]  D. Ish-Horowicz,et al.  Apical localization of pair-rule transcripts requires 3′ sequences and limits protein diffusion in the Drosophila blastoderm embryo , 1991, Cell.

[13]  H. Lipshitz,et al.  Localized RNAs and their functions , 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

[14]  J. Ahringer,et al.  Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region , 1991, Nature.

[15]  N. Hecht,et al.  Translational regulation and deadenylation of a protamine mRNA during spermiogenesis in the mouse. , 1984, Developmental biology.

[16]  R. Lehmann,et al.  Translational regulation of nanos by RNA localization , 1994, Nature.

[17]  E C Stephenson,et al.  Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis. , 1991, Development.

[18]  H. Hanafusa,et al.  Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells , 1989, Molecular and cellular biology.

[19]  M. Wickens.  In the beginning is the end: regulation of poly(A) addition and removal during early development. , 1990, Trends in biochemical sciences.

[20]  G. Ruvkun,et al.  Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans , 1993, Cell.

[21]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.

[22]  M P Deutscher,et al.  Supramolecular organization of the mammalian translation system. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Greenberg,et al.  Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. , 1991, Genes & development.

[24]  Lawrence M. Lifshitz,et al.  Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy , 1992, The Journal of cell biology.

[25]  mRNA poly(A) tail, a 3' enhancer of translational initiation. , 1990 .

[26]  D. Melton,et al.  A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. , 1990, Development.

[27]  R. Cohen,et al.  Evidence for a highly selective RNA transport system and its role in establishing the dorsoventral axis of the Drosophila egg. , 1992, Development.

[28]  Lukas C. Kühn,et al.  A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm , 1988, Cell.

[29]  R. Lenk,et al.  The cytoskeletal framework and poliovirus metabolism , 1979, Cell.

[30]  M. Wickens,et al.  The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation. , 1994, Genes & development.

[31]  W. Scheper,et al.  Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs , 1995, Molecular and cellular biology.

[32]  D. Glover,et al.  Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. , 1993, The EMBO journal.

[33]  R D Klausner,et al.  Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. , 1994, The EMBO journal.

[34]  J. Sussenbach,et al.  Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene. , 1992, Nucleic acids research.

[35]  G. Shaw,et al.  Translational blockade imposed by cytokine-derived UA-rich sequences. , 1989, Science.

[36]  N. Standart,et al.  Translation of 15‐lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region. , 1994, The EMBO journal.

[37]  R. Contreras,et al.  The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Melton,et al.  Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. , 1992, Science.

[39]  M. Deutscher,et al.  Channeling of aminoacyl-tRNA for protein synthesis in vivo. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Lenk,et al.  A cytoskeletal structure with associated polyribosomes obtained from HeLa cells , 1977, Cell.

[41]  R Parker,et al.  A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. , 1993, Genes & development.

[42]  R. Vale,et al.  RNA on the move: the mRNA localization pathway [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1625] , 1993, The Journal of cell biology.

[43]  J. Lawrence,et al.  Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization , 1989, The Journal of cell biology.

[44]  R. Harland,et al.  Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes. , 1990, Genes & development.

[45]  D. Williams,et al.  Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5'-AAU-3'/5'-UAA-3' elements in single-stranded loop domains of the 3'-noncoding region. , 1989, The Journal of biological chemistry.

[46]  P. Milos,et al.  Circadian regulation of bioluminescence in Gonyaulax involves translational control. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R. Lehmann,et al.  Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. , 1992, Genes & development.

[48]  R. Harland,et al.  Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. , 1993, Genes & development.

[49]  L. Gold,et al.  Recognition of the mRNA selenocysteine insertion sequence by the specialized translational elongation factor SELB. , 1994, Genes & development.

[50]  R. Singer,et al.  Requirement of microfilaments in sorting of actin messenger RNA. , 1991, Science.

[51]  G. Struhl,et al.  RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos , 1991, Cell.

[52]  D. Glover,et al.  3' non-translated sequences in Drosophila cyclin B transcripts direct posterior pole accumulation late in oogenesis and peri-nuclear association in syncytial embryos. , 1992, Development.

[53]  Helen M. Blau,et al.  Genetic complementation reveals a novel regulatory role for 3′ untranslated regions in growth and differentiation , 1993, Cell.

[54]  T. C. Evans,et al.  Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans , 1993, Cell.

[55]  W. Jeffery,et al.  The cytoskeletal framework of sea urchin eggs and embryos: developmental changes in the association of messenger RNA. , 1983, Developmental biology.

[56]  G. Dreyfuss,et al.  Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells , 1981, Cell.

[57]  M. Berry,et al.  Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region , 1991, Nature.

[58]  P. Schedl,et al.  Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis , 1994, Molecular and cellular biology.

[59]  R. Parker,et al.  Mutations affecting stability and deadenylation of the yeast MFA2 transcript. , 1992, Genes & development.

[60]  R. Palmiter,et al.  Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice. , 1989, Genes & development.

[61]  J. Richter.  Translational control during early development , 1991, Critical reviews in eukaryotic gene expression.

[62]  J. Hershey,et al.  Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells , 1984, Cell.

[63]  A. Christensen,et al.  Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary. , 1987, The American journal of anatomy.

[64]  R. Lehmann,et al.  Localization of nanos RNA controls embryonic polarity , 1992, Cell.

[65]  S. Penman,et al.  Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis. , 1986, Molecular and cellular biology.

[66]  D. Gallie.  The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. , 1991, Genes & development.

[67]  F. Nielsen,et al.  Endonucleolysis in the turnover of insulin-like growth factor II mRNA. , 1992, The Journal of biological chemistry.

[68]  P. Newburger,et al.  Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. , 1993, The Journal of biological chemistry.

[69]  Richard Treisman,et al.  Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences , 1988, Nature.

[70]  J. Condeelis,et al.  Identification of an actin-binding protein from Dictyostelium as elongation factor 1a , 1990, Nature.

[71]  N. Hecht,et al.  Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation , 1993, Molecular and cellular biology.

[72]  J. L. Smith,et al.  Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA. , 1993, Development.

[73]  P. Schimmel,et al.  Reversal of creatine kinase translational repression by 3' untranslated sequences. , 1990, Science.