Molecular genetics of human hypertension: role of angiotensinogen.

I. Introduction II. Structure of the AGT Gene III. Characteristics of AGT A. AGT as the substrate for renin B. AGT as a member of the serpin superfamily: other roles for AGT? IV. Tissue and Cellular Distribution V. Regulation A. Hormonal regulation of AGT B. Regulation of AGT in disease C. Regulation of AGT gene transcription VI. Molecular Genetics of AGT in Human Essential Hypertension A. Strategies B. Linkage studies C. Association studies of AGT polymorphism and high blood pressure D. Pregnancy-induced hypertension E. M235T variants, plasma AGT concentration, and blood pressure F. Association of AGT variants with the renal blood flow response to Ang II infusion VII. Molecular Genetics of AGT and Other Diseases A. AGT variants and coronary heart disease B. AGT variants and complications of diabetes C. AGT, obesity, and blood pressure VIII. Effects of AGT Gene Variants and Gene Targeting on Ang I Production and Blood Pressure A. Human studies B. Genetic studies in rats and mice C. Genetic hypertension in...

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