Comparison of sensitivities of carbon nanotube field-effect transistor biosensors with and without top metal gate

The sensitivities of biosensors using top-gate-type carbon nanotube field-effect transistors (CNT-FETs) with and without a top metal gate were compared. The CNT-FET biosensor without the top metal gate (sensor I) showed about three times higher transconductance than the one with the top metal gate (sensor II) when they were modulated by a reference gate electrode placed in a solution. Further, the sensitivity of sensor I was three times higher than sensor II. These results were attributed to the shielding effect of the top metal gate electrode placed in the solution, which was proved by a numerical simulation.

[1]  Y. Chang,et al.  Carbon nanotube DNA sensor and sensing mechanism. , 2006, Nano letters.

[2]  M. Shim,et al.  Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Hiromi Kitano,et al.  Direct examination of chemical kinetic laws by visual imagery. 3. Association of latex particles modified with antigens and antibodies , 1987 .

[4]  M. Oda,et al.  Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens. , 2000, Molecular immunology.

[5]  S. Iijima Helical microtubules of graphitic carbon , 1991, Nature.

[6]  A. Star,et al.  Carbon Nanotube Field‐Effect‐Transistor‐Based Biosensors , 2007 .

[7]  Raymond Tsui,et al.  Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors. , 2007, The Analyst.

[8]  Qian Wang,et al.  An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. , 2004, Journal of the American Chemical Society.

[9]  G. Baldwin,et al.  Nucleotide sequence of porcine liver albumin. , 1988, Nucleic acids research.

[10]  Kenzo Maehashi,et al.  Air-stable n-type carbon nanotube field-effect transistors with Si3N4 passivation films fabricated by catalytic chemical vapor deposition , 2005 .

[11]  S. Tans,et al.  Room-temperature transistor based on a single carbon nanotube , 1998, Nature.

[12]  Kazuhiko Matsumoto,et al.  Air Stable n-type Top Gate Carbon Nanotube Filed Effect Transistors with Silicon Nitride Insulator Deposited by Thermal Chemical Vapor Deposition , 2005 .

[13]  D. Rees Experimental evaluation of the effective dielectric constant of proteins. , 1980, Journal of molecular biology.

[14]  Kenzo Maehashi,et al.  Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors. , 2007, Analytical chemistry.

[15]  Kazuhiko Matsumoto,et al.  Calibration method for a carbon nanotube field-effect transistor biosensor , 2008, Nanotechnology.

[16]  E. Tu,et al.  Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[17]  S. Tanimoto,et al.  Binding kinetics of antibodies to antigens on polymer surfaces as studied by the multiple internal reflection fluorescence method , 1993 .

[18]  Siegmar Roth,et al.  Conductance spikes in single-walled carbon nanotube field-effect transistor , 1999 .

[19]  K. Besteman,et al.  Enzyme-Coated Carbon Nanotubes as Single-Molecule Biosensors , 2003 .

[20]  Kazuhiko Matsumoto,et al.  Protein Sensor Using Carbon Nanotube Field Effect Transistor , 2005 .

[21]  Herbert Shea,et al.  Single- and multi-wall carbon nanotube field-effect transistors , 1998 .

[22]  Jeong-O Lee,et al.  Detection and titer estimation of Escherichia coli using aptamer-functionalized single-walled carbon-nanotube field-effect transistors. , 2008, Small.

[23]  Kenzo Maehashi,et al.  Ultrasensitive Detection of DNA Hybridization Using Carbon Nanotube Field-Effect Transistors , 2004 .

[24]  T. Ataka,et al.  Quantitative Detection of Protein Using a Top-gate Carbon Nanotube Field Effect Transistor , 2007 .

[25]  R. Petty,et al.  The antigen-binding characteristics of antibody pools of different relative affinity. , 1972, Immunology.