Thermomechanical behavior of human carotid arteries in the passive state.

Localized heating or cooling is expanding the clinical procedures used to treat cardiovascular diseases. Advantageous implementation and development of these methods are linked indissolubly to a deeper understanding of the arterial response to combined mechanical and thermal loads. Despite this, the basic thermomechanical behavior of human blood vessels still remains largely unknown, primarily due to the lack of appropriate experimental data. In this work, the influence of temperature on the passive behavior of human carotid arteries was studied in vitro by means of inflation tests. Eleven carotid segments were tested in the range 0-200 mmHg at four different temperatures of 17, 27, 37, and 42 degrees C. The results show that the combined change of temperature and stress has a dramatic effect on the dilatation coefficient of the arterial wall, which is shifted from negative to positive depending on the stress state, whereas the structural stiffness of the arterial wall does not change appreciably in the range of temperatures tested.

[1]  J D Humphrey,et al.  Heat-induced changes in the mechanical behavior of passive coronary arteries. , 1995, Journal of biomechanical engineering.

[2]  S Sasayama,et al.  Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries. , 1987, Cardiovascular research.

[3]  W. Keatinge.  The effect of low temperatures on the responses of arteries to constrictor drugs , 1958, The Journal of physiology.

[4]  P. Dobrin,et al.  Identification of smooth muscle series elastic component in intact carotid artery. , 1977, The American journal of physiology.

[5]  C. Roy,et al.  The Elastic Properties of the Arterial Wall , 1881, The Journal of physiology.

[6]  C. Macaya,et al.  734-5 Mechanims of Radiofrequency Thermal Balloon Angioplasty. A Study with Intracoronary Ultrasound , 1995 .

[7]  N. Toda,et al.  Modification by temperature of the response of isolated aorta to stimulatory agents and transmural stimulation. , 1976, Blood vessels.

[8]  W. White,et al.  Temperature during coronary artery bypass surgery affects quality of life. , 2001, The Annals of thoracic surgery.

[9]  H Handa,et al.  Stiffness and elastic behavior of human intracranial and extracranial arteries. , 1980, Journal of biomechanics.

[10]  R. W. Lawton,et al.  The Thermoelastic Behavior of Isolated Aortic Strips of the Dog , 1954, Circulation research.

[11]  J D Humphrey,et al.  Mechanics of the arterial wall: review and directions. , 1995, Critical reviews in biomedical engineering.

[12]  M. Desco,et al.  Role of elastic fibers in cooling-induced relaxation. , 2002, Cryobiology.

[13]  L. van Erven,et al.  Thrombogenicity and intimal hyperplasia after conventional and thermal balloon dilation in normal rabbit iliac arteries. , 1992, Journal of vascular research.

[14]  G A Holzapfel,et al.  Determination of constitutive equations for human arteries from clinical data. , 2003, Journal of biomechanics.

[15]  C. Tei,et al.  Hyperthermia at 43°C for 2h Inhibits the Proliferation of Vascular Smooth Muscle Cells, but not Endothelial Cells , 2002 .

[16]  G. Langewouters,et al.  The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. , 1984, Journal of biomechanics.

[17]  Y C Fung,et al.  New experiments on shear modulus of elasticity of arteries. , 1994, The American journal of physiology.

[18]  Lysle H. Peterson,et al.  Mechanical Properties of Arteries in Vivo , 1960 .

[19]  K Hayashi,et al.  Experimental approaches on measuring the mechanical properties and constitutive laws of arterial walls. , 1993, Journal of biomechanical engineering.

[20]  B. S. Gow,et al.  Measurement of Viscoelastic Properties of Arteries in the Living Dog , 1968, Circulation research.

[21]  M. Desco,et al.  Paradoxical effects of temperature on vascular tone. , 2000, Cryobiology.

[22]  K. Boergen,et al.  Heat‐induced contraction of blood vessels , 1982, Lasers in surgery and medicine.