Anti-infective mannose receptor immune mechanism in large yellow croaker (Larimichthys crocea).

Mannose receptor (MR) is a pattern recognition receptor (PRR) that plays a significant role in immunity responses. Its role has been described extensively in mammals, but very rarely in fish. Recently, with the rapid development of an aquaculture industry cultivating large yellow croaker (Larimichthys crocea), infectious diseases caused by viruses, bacteria and parasites are becoming more frequent and more severe, in particular bacterial infections caused by Vibrio anguillarum, resulting in great economical losses. Extensive use of antibiotics as conventional treatment has led to microenvironment imbalances, development of drug-resistant bacteria and deposition of drug residues, which cause environmental pollution and ultimately affect human health. The purpose of this pilot study was to detect the transcriptional levels of C-type mannose receptor genes MRC1 (4710-bp ORF; encoding 1437 aa; a signal peptide, a SMART RICIN domain, a SMART FN2 domain, eight SMART CLECT domain, and a transmembrane helix region) and MRC2 (3996-bp ORF; encoding 1484 aa; a SMART FN2 domain, eight SMART CLECT domains, and a transmembrane region) in the liver, kidney and spleen tissues of L. crocea challenged by V. anguillarum, to explore the effective domain and the molecular response mechanisms of MRC1 and MRC2, and, ultimately, to explore the possibility of developing a vaccine targeting V. anguillarum infections.

[1]  J. Standing,et al.  Pneumocystis carinii glycoprotein A binds macrophage mannose receptors , 1995, Infection and immunity.

[2]  Ting Wang,et al.  The draft genome of the large yellow croaker reveals well-developed innate immunity , 2014, Nature Communications.

[3]  L. Martínez-Pomares,et al.  Influence of the mannose receptor in host immune responses. , 2009, Immunobiology.

[4]  J. Dan,et al.  Role of the Mannose Receptor in a Murine Model of Cryptococcus neoformans Infection , 2008, Infection and Immunity.

[5]  S. Hall,et al.  Activation of Toll-Like Receptor 4 (TLR4) by In Vivo and In Vitro Exposure of Rat Epididymis to Lipopolysaccharide from Escherichia Coli1 , 2008, Biology of reproduction.

[6]  T. Klein,et al.  Involvement of mannose receptor in cytokine interleukin-1beta (IL-1beta), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1beta (MIP-1beta), MIP-2, and KC responses, caused by attachment of Candida albicans to macrophages , 1997, Infection and immunity.

[7]  J. Gready,et al.  The C‐type lectin‐like domain superfamily , 2005, The FEBS journal.

[8]  R. Dwek,et al.  Correction: The Mannose Receptor Mediates Dengue Virus Infection of Macrophages , 2008, PLoS Pathogens.

[9]  A. Molinolo,et al.  Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[10]  Zuoyan Zhu,et al.  Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirus and Aeromonas hydrophila infection in rare minnow Gobiocypris rarus. , 2009, Fish & shellfish immunology.

[11]  R. Dwek,et al.  The Mannose Receptor Mediates Dengue Virus Infection of Macrophages , 2008, PLoS pathogens.

[12]  C. Isacke,et al.  The mannose receptor family. , 2002, Biochimica et biophysica acta.

[13]  S. Gordon,et al.  The mannose receptor: linking homeostasis and immunity through sugar recognition. , 2005, Trends in immunology.

[14]  J. Meseguer,et al.  Evolution of Lipopolysaccharide (LPS) Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF-κB Activation1 , 2009, The Journal of Immunology.

[15]  Allan R Brasier,et al.  Identification of a nuclear factor kappa B-dependent gene network. , 2003, Recent progress in hormone research.

[16]  L. Tailleux,et al.  How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis. , 2003, Trends in microbiology.

[17]  M. Nei,et al.  MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. , 2007, Molecular biology and evolution.

[18]  Richard J. Stillion,et al.  Carbohydrate‐independent recognition of collagens by the macrophage mannose receptor , 2006, European journal of immunology.

[19]  D. Nguyen,et al.  Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages , 2003, European journal of immunology.

[20]  Murugesan V. S. Rajaram,et al.  Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor γ Linking Mannose Receptor Recognition to Regulation of Immune Responses , 2010, The Journal of Immunology.

[21]  J. Qin,et al.  Molecular cloning, characterization and expression of a C-type lectin cDNA in Chinese mitten crab, Eriocheir sinensis. , 2011, Fish & shellfish immunology.

[22]  T. Fujita,et al.  The lectin‐complement pathway – its role in innate immunity and evolution , 2004, Immunological reviews.

[23]  Xiaoyan Song,et al.  A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity. , 2011, Fish and Shellfish Immunology.

[24]  H. Yao,et al.  Involvement of mannose receptor in the preventive effects of mannose in lipopolysaccharide-induced acute lung injury. , 2010, European journal of pharmacology.

[25]  D. Williams,et al.  Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor , 1991, Nature.

[26]  B. Ryffel,et al.  TLR4 gene dosage contributes to endotoxin‐induced acute respiratory inflammation , 2006, Journal of leukocyte biology.

[27]  Richard J. Stillion,et al.  Recognition of Bacterial Capsular Polysaccharides and Lipopolysaccharides by the Macrophage Mannose Receptor* , 2002, The Journal of Biological Chemistry.

[28]  A. Imrich,et al.  Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro , 2005, Journal of leukocyte biology.

[29]  M. Cushion,et al.  Pneumocystis‐mediated IL‐8 release by macrophages requires coexpression of mannose receptors and TLR2 , 2007, Journal of leukocyte biology.

[30]  Maureen E. Taylor,et al.  Collagen binding by the mannose receptor mediated through the fibronectin type II domain. , 2006, The Biochemical journal.

[31]  P. Allavena,et al.  Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program 1 , 2003, The Journal of Immunology.

[32]  Debjani Das Ghosh,et al.  MODULATION OF MACROPHAGE MANNOSE RECEPTOR AFFECTS THE UPTAKE OF VIRULENT AND AVIRULENT LEISHMANIA DONOVANI PROMASTIGOTES , 2001, The Journal of parasitology.

[33]  R. Johnston,et al.  Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages. , 1991, Journal of immunology.