Torbangun Leaves ( Coleus amboinicus Lour ) Powder Capsules Supplementation Improve Lipid Profile and Blood Pressure in Me n with Hypercholesterolemia Niken

The aim of this study was to analyze the effect of torbangun leaves powder capsules supplementation on lipid profile and blood pressure in men with hypercholesterol. This study was a single blind randomized control trial design with 26 male subjects. The inclusion criterias for subject were adults (age 25-55 years), blood total cholesterol levels ≥200 mg/dl, and signed the informed consent. Subjects were divided into two groups of one intervention (torbangun capsules) and one control (amylum) group. The intervention of 750 mg/day torbangun powder for the intervention group and 300 mg/day amylum for control group were administered for 28 days. The analysis of lipid profile results showed that the trygliseride, LDL, and HDL were not significantly affected by the torbangun intervention but it significantly decreased the total cholesterol level. The supplementation of torbangun capsules also decreased the sistolic blood pressure significantly, but not in diastolic pressure.

[1]  E. Blanco,et al.  Traditional use of plants as antihypertensive in Jipijapa, Manabí. Comparison with the literature. , 2017 .

[2]  W. Choo,et al.  Betalains: Natural plant pigments with potential application in functional foods , 2015 .

[3]  Phr Iosr,et al.  Antihyperlipidemic Activity of Torbangun Extract (Coleus amboinicus Lour) on Diabetic Rats Induced by Streptozotocin , 2015 .

[4]  T. Suryowati,et al.  IDENTIFIKASI KOMPONEN KIMIA DAN AKTIVITAS ANTIOKSIDAN DALAM TANAMAN TORBANGUN (Coleus amboinicus Lour) , 2015 .

[5]  H. Nasri,et al.  Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants , 2014, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[6]  Ming Guo,et al.  Chinese Herbal Medicine on Dyslipidemia: Progress and Perspective , 2014, Evidence-based complementary and alternative medicine : eCAM.

[7]  M. Ardalan,et al.  Antioxidant supplementation in hypertension , 2013, Journal of renal injury prevention.

[8]  Zulhaida Lubis,et al.  Gambaran Asupan Zat Gizi, Status Gizi, dan Produktivitas Kerja Pada Pekerja Pabrik Kelapa Sawit Bagerpang Estate PT. PP. Lonsum 2013 , 2013 .

[9]  S. Chiu,et al.  Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds , 2013, Evidence-based complementary and alternative medicine : eCAM.

[10]  H. Kumar,et al.  Hepatoprotective activity of Plectranthus amnoinicus against paracetamol induced hepatotoxicity in rats , 2012 .

[11]  S. A. Sulaiman,et al.  Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment , 2011, International journal of molecular sciences.

[12]  A. Thippeswamy,et al.  Antihyperglycemic and Antihyperlipidemic Activity of Plectranthus Amboinicus on Normal and Alloxan-Induced Diabetic Rats , 2011, Indian journal of pharmaceutical sciences.

[13]  A. Baky QUERCTIN PROTECTIVE ACTION ON OXIDATIVE STRESS, SORBITOL, INSULIN RESISTANCE AND BETA-CELLS FUNCTION IN EXPERIMENTAL DIABETIC RATS , 2011 .

[14]  Guan-Jhong Huang,et al.  Activities of antioxidants, α-glucosidase inhibitors and aldose reductase inhibitors of the aqueous extracts of four Flemingia species in Taiwan. , 2010 .

[15]  Roshan Patel,et al.  Antioxidant Potential of Leaves of Plectranthus amboinicus (Lour)Spreng , 2010 .

[16]  Helmizar Helmizar,et al.  ANTIOKSIDAN DALAM MASAKAN MINANG DAN POTENSI PROTEKTIF TERHADAP RISIKO PENYAKIT KARDIOVASKULAR , 2009, Jurnal Kesehatan Masyarakat Andalas.

[17]  J. Yadav,et al.  Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats , 2008, Indian journal of pharmacology.

[18]  R. Beňačka,et al.  Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats , 2008 .

[19]  K. Kondo,et al.  Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. , 2007, The American journal of clinical nutrition.

[20]  Akram A. Ali,et al.  Activities of antioxidants in plants under environmental stress. , 2006 .

[21]  Fakultas Kedokteran,et al.  Penyakit Jantung Koroner Dan Hypertensi , 2004 .

[22]  A. Gotto,et al.  HDL Cholesterol and Protective Factors in Atherosclerosis , 2004, Circulation.

[23]  S. Sharma,et al.  Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. , 2003, Journal of ethnopharmacology.

[24]  S. Kim,et al.  Associations between total body fat and serum lipid concentrations in obese human adolescents. , 2002, Annals of clinical and laboratory science.

[25]  J. Manson,et al.  Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review , 2001, Journal of the American College of Nutrition.

[26]  J. Frohlich,et al.  Recommendations for the management and treatment of dyslipidemia. Report of the Working Group on Hypercholesterolemia and Other Dyslipidemias. , 2000, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.