Incidence of Gastroesophageal Reflux in Dogs Undergoing Orthopaedic Surgery or Endoscopic Evaluation of the Upper Gastrointestinal Tract

Gastroesophageal reflux (GER) is a common event during general anaesthesia but is often underdiagnosed in veterinary medicine. The oesophageal pH in anaesthetised dogs undergoing endoscopic evaluation of the upper gastrointestinal tract (END group; n = 12) or orthopaedic surgery (ORT group; n = 12) was measured using an oesophageal probe. The dogs were sedated with acepromazine or with methadone or butorphanol, and anaesthesia was induced with propofol and maintained with isoflurane. Of the 24 dogs in this study, 21 (87.5%) had an episode of GER during anaesthesia. The incidence of GER, as well as the first, the minimum, and the maximum pH values, did not differ significantly between the groups. The mean maximum difference versus the first pH value was higher for dogs in the END group (−2.6 ± 3.5) as compared with those in the ORT group (−0.7 ± 2.5), although they were not statistically significant (p = 0.25). The administration of methadone or butorphanol had no significant effect on the development of acidic reflux or biliary reflux. In the acepromazine-sedated dogs, the incidence of GER did not differ significantly between patients undergoing an endoscopic procedure and those undergoing orthopaedic surgery; however, during endoscopy, fluctuations in the oesophageal pH can be expected, even without any clinical signs of GER.

[1]  H. van Oostrom,et al.  Effect of premedication with butorphanol or methadone on ease of endoscopic duodenal intubation in dogs. , 2017, Veterinary anaesthesia and analgesia.

[2]  E. Savarino,et al.  Impedance-pH Monitoring for Diagnosis of Reflux Disease: New Perspectives , 2017, Digestive Diseases and Sciences.

[3]  P. Belafsky,et al.  Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH , 2017, Journal of veterinary internal medicine.

[4]  V. Bellver,et al.  Opioid-induced Lower Esophageal Sphincter Dysfunction , 2015, Journal of neurogastroenterology and motility.

[5]  T. Anagnostou,et al.  The effect of the stage of the ovarian cycle (anoestrus or dioestrus) and of pregnancy on the incidence of gastro-oesophageal reflux in dogs undergoing ovariohysterectomy. , 2015, Veterinary anaesthesia and analgesia.

[6]  A. Jergens,et al.  Endoscopic Assessment of the Duodenum in Dogs with Inflammatory Bowel Disease , 2014, Journal of veterinary internal medicine.

[7]  A. Kapatkin,et al.  The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs. , 2012, Journal of veterinary internal medicine.

[8]  E. Favarato,et al.  Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia , 2011, Veterinary Research Communications.

[9]  A. Jergens,et al.  Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. , 2011, The Veterinary clinics of North America. Small animal practice.

[10]  E. Jiménez,et al.  Benign oesophageal stricture in the dog. , 2010 .

[11]  I. Savvas,et al.  The effect of pre-anaesthetic fasting time and type of food on gastric content volume and acidity in dogs. , 2009, Veterinary anaesthesia and analgesia.

[12]  D. Palombo,et al.  Epidural plus general anesthesia vs general anesthesia alone for elective aortic surgery: effects on gastric electrical activity and serum gastrin secretion. , 2009, Minerva anestesiologica.

[13]  D. Campagnol,et al.  Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs. , 2009, Veterinary anaesthesia and analgesia.

[14]  A. Bredenoord Impedance‐pH monitoring: new standard for measuring gastro‐oesophageal reflux , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[15]  Deborah V. Wilson,et al.  Effects of preanesthetic administration of morphine on gastroesophageal reflux and regurgitation during anesthesia in dogs. , 2005, American journal of veterinary research.

[16]  Deborah V. Wilson,et al.  Postanesthetic esophageal dysfunction in 13 dogs. , 2004, Journal of the American Animal Hospital Association.

[17]  C. Sternini,et al.  The opioid system in the gastrointestinal tract , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[18]  R. Sellon,et al.  Esophagitis and esophageal strictures. , 2003, The Veterinary clinics of North America. Small animal practice.

[19]  J. Izbicki,et al.  Ambulatory long-term pH monitoring in pigs , 2003, Surgical Endoscopy.

[20]  T. Rallis,et al.  Benign esophageal stricture in the dog and cat: a retrospective study of 20 cases. , 2002, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[21]  D. Zoran Gastroduodenoscopy in the dog and cat. , 2001, The Veterinary clinics of North America. Small animal practice.

[22]  D. Raptopoulos,et al.  Gastro-oesophageal reflux during anaesthesia in the dog: the effect of age, positioning and type of surgical procedure , 1995, Veterinary Record.

[23]  D. Raptopoulos,et al.  Gastro-oesophageal reflux during anaesthesia in the dog: the effect of preoperative fasting and premedication , 1995, Veterinary Record.

[24]  G. Jean,et al.  Reflux gastroœsophagien sous anesthésie caudale et halothane au masque chez l'enfant , 1992 .

[25]  H. Dodat,et al.  [Gastroesophageal reflux with combined caudal and halothane anesthesia in children]. , 1992, Annales francaises d'anesthesie et de reanimation.

[26]  A. Waterman,et al.  Measurement of the length and position of the lower oesophageal sphincter by correlation of external measurements and radiographic estimations in dogs , 1991, Veterinary Record.

[27]  Jiri Silny,et al.  Intraluminal Multiple Electric Impedance Procedure for Measurement of Gastrointestinal Motility , 1991 .

[28]  J. Hardy Large volume gastroesophageal reflux: a rationale for risk reduction in the perioperative period , 1988, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[29]  T. Demeester,et al.  Specificity and sensitivity of objective diagnosis of gastroesophageal reflux disease. , 1987, Surgery.

[30]  D. Twedt,et al.  Effect of acepromazine, diazepam, fentanyl-droperidol, and oxymorphone on gastroesophageal sphincter pressure in healthy dogs. , 1987, American journal of veterinary research.

[31]  D. Skinner,et al.  Influence of morphine on the distal oesophagus and the lower oesophageal sphincter--a manometric study. , 1985, Gut.

[32]  D. Harrold,et al.  Effects of atropine, acepromazine, meperidine, and xylazine on gastroesophageal sphincter pressure in the dog. , 1985, American journal of veterinary research.

[33]  W. Nimmo Effect of anaesthesia on gastric motility and emptying. , 1984, British journal of anaesthesia.

[34]  S. Rattan,et al.  Identification and localization of opioid receptors in the opossum lower esophageal sphincter. , 1983, The Journal of pharmacology and experimental therapeutics.

[35]  E. Vidal Colomer Gastroscopy , 1940, Revista espanola de las enfermedades del aparato digestivo.

[36]  Richard H. Johnston Esophagoscopy , 1911 .