METASTATIC MEDULLARY CARCINOMA OF THE THYROID COMPLICATED BY CUSHING'S SYNDROME

A patient with metastatic medullary carcinoma of the thyroid, Cushing's syndrome, and severe diarrhoea is presented. The manifestations of Cushing's syndrome were controlled with a combination of aminogluthethimide and metyrapone. The cause of the diarrhoea has not been found, and it remains resistant to treatment.

[1]  T. Fraser,et al.  DRUG CONTROL OF CUSHING'S SYNDROME , 1976 .

[2]  B. Hill,et al.  Diarrhoea in Thyroid Medullary Carcinoma: Role of Prostaglandins and Therapeutic Effect of Nutmeg , 1975 .

[3]  N. Samaan,et al.  MEDULLARY (SOLID) CARCINOMA OF THE THYROID GLAND: AN ANALYSIS OF THE M. D. ANDERSON HOSPITAL EXPERIENCE WITH PATIENTS WITH THE TUMOR, ITS SPECIAL FEATURES, AND ITS HISTOGENESIS , 1973, Medicine.

[4]  A. Tashjian,et al.  Cushing's syndrome caused by ACTH- and calcitonin-secreting medullary carcinoma of the thyroid. , 1970, Metabolism: clinical and experimental.

[5]  A. Steiner,et al.  STUDY OF A KINDRED WITH PHEOCHROMOCYTOMA, MEDULLARY THYROID CARCINOMA, HYPERPARATHYROIDISM AND GUSHING 'S DISEASE: MULTIPLE ENDOCRINE NEOPLASIA, TYPE 21 , 1968, Medicine.

[6]  W. Hartmann,et al.  Familial amyloid-producing medullary thyroid carcinoma and pheochromocytoma. A distinct genetic entity. , 1965, Annals of internal medicine.

[7]  J. Sipple.  The association of pheochromocytoma with carcinoma of the thyroid gland , 1961 .

[8]  J. Hazard.  The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A review. , 1977, The American journal of pathology.

[9]  T. Fraser,et al.  Drug controlled of Cushing's syndrome. Combined aminoglutethimide and metyrapone therapy. , 1976, Acta endocrinologica.

[10]  D. Rimoin,et al.  Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. , 1968, The New England journal of medicine.

[11]  J. Hazard,et al.  Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. , 1959, The Journal of clinical endocrinology and metabolism.