Pharmacogenomics of tamoxifen and irinotecan therapies.
暂无分享,去创建一个
[1] S. Hirohashi,et al. Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients. , 2008, Cancer letters.
[2] P. Houghton,et al. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11 , 2008, Cancer Gene Therapy.
[3] M. Bally,et al. Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors , 2008, Clinical Cancer Research.
[4] M. Goetz,et al. Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response , 2008, Clinical pharmacology and therapeutics.
[5] M. Ingelman-Sundberg,et al. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. , 2007, Pharmacology & therapeutics.
[6] E. Bandrés,et al. Combining chemotherapy and targeted therapies in metastatic colorectal cancer. , 2007, World journal of gastroenterology.
[7] Wolfgang Simon,et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] Soma Das,et al. Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group Study. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] Joseph G Ibrahim,et al. UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters. , 2007, Journal of the National Cancer Institute.
[10] J. Panetta,et al. UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] Linnea M Baudhuin,et al. Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism. , 2007, Clinical biochemistry.
[12] Tae Won Kim,et al. Insights, Challenges, and Future Directions in Irinogenetics , 2007, Therapeutic drug monitoring.
[13] Y. Hasegawa,et al. UGT1AI*6 and UGT1A1*27 for individualized irinotecan chemotherapy. , 2007, Current opinion in molecular therapeutics.
[14] M. Narabayashi,et al. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer , 2007, Cancer Chemotherapy and Pharmacology.
[15] Q. Pan,et al. Validation of Rapid Polymerase Chain Reaction-based Detection of All Length Polymorphisms in the UGT 1A1 Gene Promoter , 2007, Diagnostic molecular pathology : the American journal of surgical pathology, part B.
[16] S. Wingren,et al. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer , 2007, Breast Cancer Research.
[17] M. Ratain,et al. The Role of SN‐38 Exposure, UGT1A1*28 Polymorphism, and Baseline Bilirubin Level in Predicting Severe Irinotecan Toxicity , 2007, Journal of clinical pharmacology.
[18] M. Ratain,et al. Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping. , 2006, Pharmacogenomics.
[19] W. Burke,et al. Adding pharmacogenetics information to drug labels: lessons learned , 2006, Pharmacogenetics and genomics.
[20] D. Young. Genetics examined in tamoxifen's effectiveness: recurrence warning urged for labeling. , 2006, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[21] M. Narabayashi,et al. Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN‐38 glucuronidation in Japanese patients with cancer , 2006, Cancer science.
[22] T. Bevers. Raloxifene and the prevention of breast cancer , 2006, Expert opinion on pharmacotherapy.
[23] S. Loibl,et al. Venlafaxine is superior to clonidine as treatment of hot flashes in breast cancer patients--a double-blind, randomized study. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.
[24] P. O'dwyer,et al. Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: practical pharmacogenomics arrives in cancer therapy. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] B. Bonanni,et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[26] Zeruesenay Desta,et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment , 2006, Clinical pharmacology and therapeutics.
[27] Norman Wolmark,et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. , 2006, JAMA.
[28] M. Ratain,et al. Irinogenetics: what is the right star? , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[29] R. Gelber,et al. Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: International Breast Cancer Study Group Trial 13-93. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[30] R. Remmel,et al. Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer , 2006, Oncogene.
[31] Fergus J Couch,et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] Thomas J. Smith,et al. Review: chemotherapy and hormonal therapy reduce recurrence and mortality at 15 years in early breast cancer , 2005, ACP journal club.
[33] J. Scheys,et al. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients , 2005, Breast Cancer Research and Treatment.
[34] G. Wilkinson,et al. Drug metabolism and variability among patients in drug response. , 2005, The New England journal of medicine.
[35] Y Wang,et al. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials , 2005, The Lancet.
[36] N. Meropol,et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[37] T. Skaar,et al. Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen , 2005, Cancer Chemotherapy and Pharmacology.
[38] L. Skoog,et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients , 2005, Breast Cancer Research.
[39] J. Flaws,et al. Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. , 2005, Cancer letters.
[40] David A. Flockhart,et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. , 2005, Journal of the National Cancer Institute.
[41] J. Cuzick,et al. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer , 2005, The Lancet.
[42] David A. Flockhart,et al. Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6 , 2004, Journal of Pharmacology and Experimental Therapeutics.
[43] J. Verweij,et al. Influence of Genetic Variants in UGT1A1 and UGT1A9 on the In Vivo Glucuronidation of SN‐38 , 2004, Journal of clinical pharmacology.
[44] J. Verweij,et al. Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38 , 2004 .
[45] T. Skaar,et al. Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen , 2004, Breast Cancer Research and Treatment.
[46] Soma Das,et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[47] J. Watters,et al. Irinotecan pharmacogenetics: is it time to intervene? , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[48] Jeffrey Cummings,et al. Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. , 2003, Cancer research.
[49] C. Guillemette,et al. Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs , 2003, Journal of Pharmacology and Experimental Therapeutics.
[50] V. Stearns,et al. Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial. , 2003, JAMA.
[51] M. Ingelman-Sundberg,et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[52] Guangping Chen,et al. 4‐Hydroxytamoxifen sulfation metabolism , 2002, Journal of biochemical and molecular toxicology.
[53] L. Hutchins,et al. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. , 2002, Journal of the National Cancer Institute.
[54] J. Brockmöller,et al. Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[55] C. Guillemette,et al. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). , 2002, Molecular pharmacology.
[56] M. Eichelbaum,et al. The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver. , 2002, British journal of clinical pharmacology.
[57] E. Gillam,et al. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[58] M. Ando,et al. Genetic Polymorphisms of the UDP‐Glucuronosyltransferase 1A7 Gene and Irinotecan Toxicity in Japanese Cancer Patients , 2002, Japanese journal of cancer research : Gann.
[59] S. Ozawa,et al. Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[60] C K Redmond,et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. , 1999, Journal of the National Cancer Institute.
[61] Osborne Ck,et al. Tamoxifen in the Treatment of Breast Cancer , 1998 .
[62] S. Lundgren,et al. Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment. , 1989, Cancer research.
[63] H. Rochefort,et al. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. , 1981, The Journal of biological chemistry.
[64] V. Jordan,et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. , 1977, The Journal of endocrinology.
[65] S. Lundgren,et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[66] David A. Flockhart,et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen , 2006, Breast Cancer Research and Treatment.
[67] Yoshiro Saito,et al. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[68] H. Rochefort,et al. Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. , 1982, Cancer research.
[69] B. Katzenellenbogen,et al. Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. , 1982, Journal of steroid biochemistry.