Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis.

OBJECTIVE To ascertain the relationship between serum leptin levels and related variables (weight, Body Mass Index (BMI) and fat percentage) in a group of Omani obese and non-obese healthy subjects. METHODS Leptin levels were assessed in serum samples from 35 obese Omanis and 20 non-obese healthy subjects. RESULTS There was a significant difference (p< 0.001) in serum leptin between the obese group (34.78 + 13.96 ng/ml) and the control non-obese subjects (10.6 ± 4.2 ng/ml). Leptin levels were higher in females compared to males. There was a significantly positive correlation between leptin levels in obese subjects with weight (p=0.002), body fat percentage (p=0.0001) and BMI (p=0.001). CONCLUSIONS We concluded that serum leptin levels are higher in the Omani obese group and correlate positively with body fatness and obesity.

[1]  M. Phoon,et al.  Measurement of serum leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex. , 2003, Advances in physiology education.

[2]  E. Rimm,et al.  Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. , 2001, Atherosclerosis.

[3]  N. Hoggard,et al.  Leptin: fundamental aspects , 1999, International Journal of Obesity.

[4]  L. Carlsson,et al.  Expression of functional leptin receptors in the human ovary. , 1997, The Journal of clinical endocrinology and metabolism.

[5]  M. Mozzoli,et al.  Effect of fasting on serum leptin in normal human subjects. , 1996, The Journal of clinical endocrinology and metabolism.

[6]  F. Lönnqvist,et al.  Low leptin gene expression and hyperleptinemia in chronic renal failure. , 1998, Kidney international.

[7]  R. Leibel,et al.  Effects of gender, body composition, and menopause on plasma concentrations of leptin. , 1996, The Journal of clinical endocrinology and metabolism.

[8]  R. Considine,et al.  Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.

[9]  R. Janečková.  The role of leptin in human physiology and pathophysiology. , 2001, Physiological research.

[10]  E. Ravussin,et al.  Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects , 1995, Nature Medicine.

[11]  H. Makhlouf,et al.  Leptin levels in Arabs with primary hyperthyroidism. , 2000, Annals of Saudi medicine.

[12]  V. Emilsson,et al.  Leptin signalling in pancreatic islets and clonal insulin-secreting cells. , 1999, Journal of molecular endocrinology.

[13]  R. Valcavi,et al.  Influence of thyroid status on serum immunoreactive leptin levels. , 1997, The Journal of clinical endocrinology and metabolism.

[14]  J. Al-Lawati,et al.  Body fat distribution and the risk of non-insulin-dependent diabetes mellitus in the Omani population. , 1999, Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit.

[15]  J. Svobodová,et al.  Relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition. , 1999, Nutrition.

[16]  V. Funanage,et al.  Leptin and estradiol as related to change in pubertal status and body weight. , 2002, Medical science monitor : international medical journal of experimental and clinical research.

[17]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[18]  F. Lönnqvist,et al.  Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. , 1997, The Journal of clinical investigation.

[19]  C. Mantzoros,et al.  Sex differences in circulating human leptin pulse amplitude: clinical implications. , 1998, The Journal of clinical endocrinology and metabolism.

[20]  B. Persson,et al.  Serum Leptin Levels in Young Females with Insulin-Dependent Diabetes and the Relationship to Hyperandrogenicity and Microalbuminuria , 1998, Hormone Research in Paediatrics.

[21]  P. Jousilahti,et al.  Increasing prevalence of diabetes mellitus in Oman , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[22]  H. King,et al.  High Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in the Sultanate of Oman: Results of the 1991 National Survey , 1995, Diabetic medicine : a journal of the British Diabetic Association.