Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA‐E double transgenic pig forelimbs with human blood

Besides α1,3‐galactosyltransferase gene (GGTA1) knockout, several transgene combinations to prevent pig‐to‐human xenograft rejection are currently being investigated. In this study, the potential of combined overexpression of human CD46 and HLA‐E to prevent complement‐ and NK‐cell‐mediated xenograft rejection was tested in an ex vivo pig‐to‐human xenoperfusion model.

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