Der Einsatz der transkraniellen Magnetstimulation beim psychogenen Tremor – eine Pilotstudie

! Psychogenic tremor is the most common psychogenic movement disorder. Its prognosis is widely held to be poor and strongly depends on the patient ’ s insight into the psychogenicity of the syndrome. The clinical value of transcranial magnetic stimulation (TMS) for (i) establishing the diagnosis with a high level of certainty, (ii) modulating symptom severity and (iii) facilitating patients ’ insight into psychogenicity was tested in 11 patients with psychogenic tremor of the upper limb. After explaining the psychogenic origin of the syndrome and providing a neurobiological model, 30 TMS pulses were applied over the hand area of the primary motor cortex contralateral to the affected hand(s) at a rate of 0.2Hz. 15 pulses were administered at intensities of 120% and 140% of the resting motor threshold, respectively. Kinematic motion analysis was used to document the effectiveness of the TMS procedure.

[1]  G. Fink,et al.  Electrical somatosensory stimulation improves movement kinematics of the affected hand following stroke , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[2]  G. Fink,et al.  Psychogener Tremor , 2008, Fortschritte der Neurologie-Psychiatrie.

[3]  Dennis A. Nowak,et al.  The impact of stroke on the performance of grasping: Usefulness of kinetic and kinematic motion analysis , 2008, Neuroscience & Biobehavioral Reviews.

[4]  G. Fink,et al.  The impact of subthalamic deep brain stimulation on bradykinesia of proximal and distal upper limb muscles in Parkinson's disease , 2008, Journal of Neurology.

[5]  A. Margalit,et al.  Costly patients with unexplained medical symptoms: a high-risk population. , 2008, Patient education and counseling.

[6]  Kailash P. Bhatia,et al.  Psychogenic tremor and related disorders , 2007, Journal of Neurology.

[7]  Sarah H Lisanby,et al.  International Society for Transcranial Stimulation Consensus Statement: Managing the Risks of Repetitive Transcranial Stimulation , 2003, CNS Spectrums.

[8]  Á. Pascual-Leone,et al.  Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation , 2000, Clinical Neurophysiology.

[9]  A. Lang,et al.  Historical and Clinical Features of Psychogenic Tremor: a Review of 70 Cases , 1999, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[10]  R. Fisher,et al.  Ethical use of placebos and provocative testing in diagnosing nonepileptic seizures , 1996, Neurology.

[11]  T. Brandt,et al.  Psychogenic disorders in neurology: frequency and clinical spectrum , 1990, Acta neurologica Scandinavica.

[12]  A. Lewis,et al.  ‘Psychogenic’: a word and its mutations , 1972, Psychological Medicine.

[13]  Patrik Vuilleumier,et al.  Hysterical conversion and brain function. , 2005, Progress in brain research.

[14]  S. Fahn,et al.  Phenomenology and psychopathology related to psychogenic movement disorders. , 1995, Advances in neurology.