Use of population isolates for mapping complex traits

[1]  A. Tsalenko,et al.  A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. , 2000, American journal of human genetics.

[2]  Joseph B. Rayman,et al.  The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. , 2000, American journal of human genetics.

[3]  K. Stefánsson,et al.  Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. , 2000, American journal of human genetics.

[4]  L. Peltonen,et al.  Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo , 2000, European Journal of Human Genetics.

[5]  T. C. Nesbitt,et al.  fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. , 2000, Science.

[6]  John A. Todd,et al.  The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes , 2000, Nature Genetics.

[7]  Pui-Yan Kwok,et al.  Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28 , 2000, Nature Genetics.

[8]  Jonathan Scott Friedlaender,et al.  Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations. , 2000, American journal of human genetics.

[9]  W. Honer,et al.  Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. , 2000, Science.

[10]  H H Göring,et al.  Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. , 2000, American journal of human genetics.

[11]  J. Xu Combined analysis of hereditary prostate cancer linkage to 1q24-25: results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. , 2000, American journal of human genetics.

[12]  K Lange,et al.  Gamete-competition models. , 2000, American journal of human genetics.

[13]  Andreas Busjahn,et al.  Support for linkage of familial combined hyperlipidemia to chromosome 1q21–q23 in Chinese and German families , 2000, Clinical genetics.

[14]  L. Peltonen,et al.  Linkage disequilibrium related to the demographic history of isolated populations: Finland and a young subpopulation of Kuusamo , 2000 .

[15]  Mario Pirastu,et al.  Population choice in mapping genes for complex diseases , 1999, Nature Genetics.

[16]  J. Suvisaari,et al.  A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. , 1999, American journal of human genetics.

[17]  M. McPeek,et al.  Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping. , 1999, American journal of human genetics.

[18]  Leena Peltonen,et al.  Positional Cloning of Disease Genes: Advantages of Genetic Isolates , 1999, Human Heredity.

[19]  J. Kere,et al.  Gene Mapping in Isolated Populations: New Roles for Old Friends? , 1999, Human Heredity.

[20]  S E Hodge,et al.  Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. , 1999, American journal of human genetics.

[21]  E. Martin,et al.  Sibling-based tests of linkage and association for quantitative traits. , 1999, American journal of human genetics.

[22]  L. Kruglyak Prospects for whole-genome linkage disequilibrium mapping of common disease genes , 1999, Nature Genetics.

[23]  L R Goldin,et al.  A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J D Terwilliger,et al.  Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. , 1999, American journal of human genetics.

[25]  M. Leppert,et al.  A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. , 1999, Diabetes.

[26]  N Risch,et al.  The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. , 1999, Genome research.

[27]  T Varilo,et al.  Molecular genetics of the Finnish disease heritage. , 1999, Human molecular genetics.

[28]  N Risch,et al.  The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. , 1998, Genome research.

[29]  D J Schaid,et al.  Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease. , 1998, American journal of human genetics.

[30]  F. Wright,et al.  Linkage disequilibrium mapping in isolated populations: the example of Finland revisited. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Ehm,et al.  An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. , 1998, American journal of human genetics.

[32]  V. Sheffield,et al.  Use of isolated inbred human populations for identification of disease genes. , 1998, Trends in genetics : TIG.

[33]  P. Goodfellow,et al.  The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. , 1998, Brain : a journal of neurology.

[34]  E. Lander,et al.  Genome-Wide Search for Asthma Susceptibility Loci in a Founder Population , 1998 .

[35]  S E Hodge,et al.  The power to detect linkage in complex disease by means of simple LOD-score analyses. , 1998, American journal of human genetics.

[36]  E. Boerwinkle,et al.  DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene , 1998, Nature Genetics.

[37]  W. Vogel,et al.  Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. , 1998, American journal of human genetics.

[38]  J. Terwilliger,et al.  Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion , 1998, Human Heredity.

[39]  L. Peltonen,et al.  Dual origins of Finns revealed by Y chromosome haplotype variation. , 1998, American journal of human genetics.

[40]  L. Almasy,et al.  Multipoint quantitative-trait linkage analysis in general pedigrees. , 1998, American journal of human genetics.

[41]  M. Boehnke,et al.  Genetic association mapping based on discordant sib pairs: the discordant-alleles test. , 1998, American journal of human genetics.

[42]  A. Lusis,et al.  Mapping a gene for combined hyperlipidaemia in a mutant mouse strain , 1998, Nature Genetics.

[43]  T. Lehtimäki,et al.  Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23 , 1998, Nature Genetics.

[44]  K. Lange,et al.  A Conditional Inference Framework for Extending the Transmission/Disequilibrium Test , 1998, Human Heredity.

[45]  A Collins,et al.  Mapping a disease locus by allelic association. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[46]  W. Ewens,et al.  A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. , 1998, American journal of human genetics.

[47]  L. Cavalli-Sforza The DNA revolution in population genetics. , 1998, Trends in genetics : TIG.

[48]  B Rannala,et al.  Likelihood analysis of disequilibrium mapping, and related problems. , 1998, American journal of human genetics.

[49]  L Kruglyak,et al.  Genome scan of schizophrenia. , 1996, The American journal of psychiatry.

[50]  M. Daly,et al.  Genomewide scan of multiple sclerosis in Finnish multiplex families. , 1997, American journal of human genetics.

[51]  Francis S. Collins,et al.  Variations on a Theme: Cataloging Human DNA Sequence Variation , 1997, Science.

[52]  M. Xiong,et al.  Fine-scale genetic mapping based on linkage disequilibrium: theory and applications. , 1997, American journal of human genetics.

[53]  D. Kelsell,et al.  Connexin 26 mutations in hereditary non-syndromic sensorineural deafness , 1997, nature.

[54]  Farhad Imani,et al.  A genome-wide search for asthma susceptibility loci in ethnically diverse populations , 1997, Nature Genetics.

[55]  L. Almasy,et al.  Multipoint oligogenic linkage analysis of quantitative traits , 1997, Genetic epidemiology.

[56]  D A Meyers,et al.  Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search , 1996, Science.

[57]  S. Pääbo,et al.  Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[58]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[59]  K. Roeder,et al.  Disequilibrium mapping: composite likelihood for pairwise disequilibrium. , 1996, Genomics.

[60]  P. Goodfellow,et al.  A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22 , 1996, Nature Genetics.

[61]  Leena Peltonen,et al.  A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2 , 1996, Nature Genetics.

[62]  K Lange,et al.  Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. , 1996, American journal of human genetics.

[63]  L Kruglyak,et al.  Parametric and nonparametric linkage analysis: a unified multipoint approach. , 1996, American journal of human genetics.

[64]  J. Weissenbach,et al.  A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish , 1996, Nature Genetics.

[65]  J. Weissenbach,et al.  An international two–stage genome–wide search for schizophrenia susceptibility genes , 1995, Nature Genetics.

[66]  R. Straub,et al.  A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity , 1995, Nature Genetics.

[67]  V. Sheffield,et al.  Nonsyndromic autosomal recessive deafness is linked to the DFNB1 locus in a large inbred Bedouin family from Israel. , 1995, American journal of human genetics.

[68]  L. Peltonen,et al.  Random search for shared chromosomal regions in four affected individuals: the assignment of a new hereditary ataxia locus. , 1995, American journal of human genetics.

[69]  J. Terwilliger A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. , 1995, American journal of human genetics.

[70]  B S Weir,et al.  Likelihood methods for locating disease genes in nonequilibrium populations. , 1995, American journal of human genetics.

[71]  Masashi Yanagisawa,et al.  A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease , 1994, Cell.

[72]  T. Matise,et al.  Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. , 1994, Human molecular genetics.

[73]  D. Ward,et al.  Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer , 1994, Nature.

[74]  C. Amos Robust variance-components approach for assessing genetic linkage in pedigrees. , 1994, American journal of human genetics.

[75]  J. Weissenbach,et al.  A non–syndromic form of neurosensory, recessive deafness maps to the pericentromeric region of chromosome 13q , 1994, Nature Genetics.

[76]  Nelson B. Freimer,et al.  Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis , 1994, Nature Genetics.

[77]  Robin J. Leach,et al.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.

[78]  N. Schork,et al.  Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. , 1993, American journal of human genetics.

[79]  J. Weber,et al.  Genetic mapping of a locus predisposing to human colorectal cancer. , 1993, Science.

[80]  W. Ewens,et al.  Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). , 1993, American journal of human genetics.

[81]  J. Terwilliger,et al.  A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. , 1992, Human heredity.

[82]  D. Goldgar Multipoint analysis of human quantitative genetic variation. , 1990, American journal of human genetics.

[83]  C. Bonaïti‐pellié,et al.  Effects of misspecifying genetic parameters in lod score analysis. , 1986, Biometrics.

[84]  Béla Bollobás,et al.  Littlewood's Miscellany , 1986 .

[85]  J. Mathews,et al.  Extensions to multivariate normal models for pedigree analysis , 1982, Annals of human genetics.