Rejection of an HL-A identical renal transplant.

A 38-year-old man suffering from chronic glomerulonephritis received a kidney from his HL—A identical sister. The HL—A identity was fully established by tissue typing with well-specified antisera and by mixed lymphocyte culture tests. One year after transplantation kidney function deteriorated, and repeated biopsies of the transplant, I131-Hippuran renography, and arteriography showed that the kidney was undergoing a chronic rejection. It is suggested that incompatibilities with regard to weak histocompatibility systems might have been responsible for the rejection of a human kidney.

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