Meconium samples used to assess infant exposure to the components of ETS during pregnancy.

OBJECTIVES The aim of the study was to use meconium samples to assess fetal exposure to compounds present in environmental tobacco smoke (ETS). MATERIAL AND METHODS In order to assess fetal exposure to toxic tobacco smoke compounds, samples of meconium from the offspring of women with different levels of tobacco smoke exposure, and the samples of saliva from the mothers were analyzed. Thiocyanate ion as a biomarker of tobacco smoke exposure, and other ions that are indices of such exposure were determined by means of ion chromatography. RESULTS The results of ion chromatography analysis of the meconium and maternal saliva samples for the presence of cations and anions (including thiocyanate ion) indicate that the concentration level of specific ions depends on the intensity of environmental tobacco smoke exposure of pregnant women. CONCLUSIONS Based on the results, it can be concluded that meconium samples can be used to determine the substances from tobacco smoke. The results confirm the effect of smoking during pregnancy on the presence and content of substances from tobacco smoke.

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