Radioimmunoassays of abrin and ricin in blood.

Radioimmunoassays for abrin and ricin are described. There is little cross-reactivity between the two toxins. The procedures described are capable of determining blood concentrations down to 50-100 pg/ml, permitting identification of abrin and ricin poisoning and monitoring of the blood concentrations in cancer patients treated with these agents.

[1]  Ø. Fodstad,et al.  Effect of ricin and abrin on survival of L1210 leukemic mice and on leukemic and normal bone‐marrow cells , 1978, International journal of cancer.

[2]  A. Pihl,et al.  Mechanism of action of the toxic lectins abrin and ricin , 1974, Nature.

[3]  A. Pihl,et al.  Toxic lectins and related proteins , 1982 .

[4]  O. Fodstad,et al.  Toxicity of abrin and ricin in mice and dogs. , 1979, Journal of Toxicology and Environmental Health, Part A.

[5]  O. Fodstad,et al.  Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. , 1977, Cancer research.

[6]  F. Stirpe,et al.  Toxic effects of ricin , 1976, Virchows Archiv B Cell Pathology.

[7]  K. Tserng,et al.  Abrin and Ricin: New Anti-tumour Substances , 1970, Nature.

[8]  K. Sandvig,et al.  Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells. , 1976, The Journal of biological chemistry.

[9]  A. Pihl,et al.  Abrin, Ricin, and their Associated Agglutinins , 1977 .

[10]  S. Flexner THE HISTOLOGICAL CHANGES PRODUCED BY RICIN AND ABRIN INTOXICATIONS , 1897, The Journal of experimental medicine.

[11]  H. Stillmark Ueber Ricin, ein giftiges Ferment aus den Samen von Ricinus comm. L. und einigen anderen Euphorbiaceen : Inaugural-Dissertation , 1888 .

[12]  P. Fraker,et al.  Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. , 1978, Biochemical and biophysical research communications.

[13]  G A Balint,et al.  Ricin: the toxic protein of castor oil seeds. , 1974, Toxicology.

[14]  S. Olsnes Ricin and ricinus agglutinin, toxic lectins from castor bean. , 1978, Methods in enzymology.

[15]  S. Olsnes,et al.  Conformation-dependent antigenic determinants in the toxic lectin ricin. , 1975, Journal of immunology.

[16]  S. Olsnes [34] Toxic and nontoxic lectins from Abrus precatorius , 1978 .

[17]  O. Fodstad,et al.  Synergistic effect of adriamycin and ricin on L1210 leukemic cells in mice. , 1980, Cancer research.

[18]  S. Olsnes,et al.  Purification and characterization of the highly toxic lectin modeccin. , 1978, The Journal of biological chemistry.

[19]  Joseph S. Fruton,et al.  The Collected Papers of Paul Ehrlich , 1957, The Yale Journal of Biology and Medicine.

[20]  B. Knight Ricin--a potent homicidal poison. , 1979, British medical journal.

[21]  O. Fodstad,et al.  Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. , 1976, British Journal of Cancer.