Anomaly detection through registration

We study an application of image registration in the medical domain. Based on a 3-D hierarchical deformable registration algorithm, we have developed a prototype system which automatically aligns a standard atlas to a subject's data to create a customized atlas. Combined with domain knowledge, the registration algorithm can also detect asymmetries and abnormal variations in the subject's data that indicate the existence and location of pathologies. We have conducted tests on 106 MRI scans of normal brains, 3 MRI and 1 CT scan of brains with pathologies, with results qualitatively comparable to manual segmentation.

[1]  Michael I. Miller,et al.  Deformable templates using large deformation kinematics , 1996, IEEE Trans. Image Process..

[2]  Jean-Philippe Thirion,et al.  Fast Non-Rigid Matching of 3D Medical Images , 1995 .

[3]  M. Viergever,et al.  Medical image matching-a review with classification , 1993, IEEE Engineering in Medicine and Biology Magazine.

[4]  Michael I. Miller,et al.  Individualizing Neuroanatomic Atlases Using a Massively Parallel Computer , 1996, Computer.

[5]  Ruzena Bajcsy,et al.  Multiresolution elastic matching , 1989, Comput. Vis. Graph. Image Process..

[6]  Alex Pentland,et al.  A Bayesian similarity measure for direct image matching , 1996, Proceedings of 13th International Conference on Pattern Recognition.

[7]  Alex Pentland,et al.  Modal Matching for Correspondence and Recognition , 1995, IEEE Trans. Pattern Anal. Mach. Intell..

[8]  Paul A. Viola,et al.  Multi-modal volume registration by maximization of mutual information , 1996, Medical Image Anal..

[9]  R. Bajcsy,et al.  Elastically Deforming 3D Atlas to Match Anatomical Brain Images , 1993, Journal of computer assisted tomography.

[10]  Berthold K. P. Horn,et al.  Closed-form solution of absolute orientation using unit quaternions , 1987 .

[11]  Max A. Viergever,et al.  Evaluation of Ridge Seeking Operators for Multimodality Medical Image Matching , 1996, IEEE Trans. Pattern Anal. Mach. Intell..

[12]  Philippe Cinquin,et al.  Image guided operating robot: a clinical application in stereotactic neurosurgery , 1992, Proceedings 1992 IEEE International Conference on Robotics and Automation.

[13]  Demetri Terzopoulos,et al.  Deformable models in medical image analysis: a survey , 1996, Medical Image Anal..

[14]  Guy Marchal,et al.  Multimodality image registration by maximization of mutual information , 1997, IEEE Transactions on Medical Imaging.

[15]  Guido Gerig,et al.  Segmentation of 2-D and 3-D objects from MRI volume data using constrained elastic deformations of flexible Fourier contour and surface models , 1996, Medical Image Anal..

[16]  Stan Sclaroff,et al.  On modal modeling for medical images: underconstrained shape description and data compression , 1994, Proceedings of IEEE Workshop on Biomedical Image Analysis.

[17]  E ChristensenGary,et al.  Individualizing Neuroanatomical Atlases Using a Massively Parallel Computer , 1996 .