Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12 p 12 . 3

Rongxi Yang1,2,*, Bowang Chen3, Katrin Pfütze1,2, Stephan Buch4, Verena Steinke5, Elke Holinski-Feder6, Sarah Stöcker2, Witigo von Schönfels7, Thomas Becker7, Hans K.Schackert8, Brigitte Royer-Pokora9, Matthias Kloor10, Wolff H.Schmiegel11, Reinhard Büttner12, Christoph Engel13, Jesus Lascorz Puertolas3, Asta Försti3,14, Nelli Kunkel3, Peter Bugert15, Stefan Schreiber4,16, Michael Krawczak17, Clemens Schafmayer7, Peter Propping5, Jochen Hampe4, Kari Hemminki3,14 and Barbara Burwinkel1,2

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