Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.

[1]  H. Koepsell,et al.  Subtype-Specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region , 2005, Molecular Pharmacology.

[2]  H. Koepsell,et al.  Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease , 2005, Molecular Pharmacology.

[3]  H. Koepsell,et al.  Regulation of the human organic cation transporter hOCT1 , 2004, Journal of cellular physiology.

[4]  Merlin C. Thomas,et al.  The Role of Advanced Glycation in Reduced Organic Cation Transport Associated with Experimental Diabetes , 2004, Journal of Pharmacology and Experimental Therapeutics.

[5]  Thomas Ludwig,et al.  Nephrotoxicity of platinum complexes is related to basolateral organic cation transport. , 2004, Kidney international.

[6]  S. Wright,et al.  Molecular and cellular physiology of renal organic cation and anion transport. , 2004, Physiological reviews.

[7]  D. Buckley,et al.  Reduced Expression of Organic Cation Transporters rOCT1 and rOCT2 in Experimental Diabetes , 2004, Journal of Pharmacology and Experimental Therapeutics.

[8]  J. Zisowsky,et al.  Assessment of platinum sensitivity in human tumor cells. , 2003, International journal of clinical pharmacology and therapeutics.

[9]  T. Boulikas,et al.  Cisplatin and platinum drugs at the molecular level. (Review). , 2003, Oncology reports.

[10]  Merlin C. Thomas,et al.  Reduced tubular cation transport in diabetes: prevented by ACE inhibition. , 2003, Kidney international.

[11]  H. Koepsell,et al.  Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. , 2003, American journal of physiology. Renal physiology.

[12]  D. Barfuss,et al.  Inhibition of basolateral transport and cellular accumulation of cDDP and N-acetyl-L-cysteine-cDDP by TEA and PAH in the renal proximal tubule , 2003, Cancer Chemotherapy and Pharmacology.

[13]  K. Çağlar,et al.  Cumulative prior dose of cisplatin as a cause of the nephrotoxicity of high-dose chemotherapy followed by autologous stem-cell transplantation. , 2002, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  C. A. Boicelli,et al.  Protective effect of procaine hydrochloride on cisplatin-induced alterations in rat kidney , 2002, Anti-cancer drugs.

[15]  S. Heidenreich,et al.  Down-Regulation of Monocyte Apoptosis by Phagocytosis of Platelets: Involvement of a Caspase-9, Caspase-3, and Heat Shock Protein 70-Dependent Pathway1 , 2002, The Journal of Immunology.

[16]  Hideyuki Saito,et al.  Gene expression levels and immunolocalization of organic ion transporters in the human kidney. , 2002, Journal of the American Society of Nephrology : JASN.

[17]  R E Stoll,et al.  Assessment of cisplatin-induced nephrotoxicity by microarray technology. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[18]  E. Schlatter,et al.  Properties and Regulation of Organic Cation Transport in Freshly Isolated Human Proximal Tubules* , 2001, The Journal of Biological Chemistry.

[19]  T. A. Najjar,et al.  Cisplatin Pharmacokinetics and Its Nephrotoxicity in Diabetic Rabbits , 2001, Chemotherapy.

[20]  H. Koepsell,et al.  The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation. , 2000, Journal of the American Society of Nephrology : JASN.

[21]  T. Endo,et al.  Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line. , 2000, Toxicology.

[22]  U. Jaehde,et al.  Determination of platinum complexes in clinical samples by a rapid flameless atomic absorption spectrometry assay. , 1999, Therapeutic drug monitoring.

[23]  K. Hanada,et al.  Effects of Disopyramide and Verapamil on Renal Disposition and Nephrotoxicity of Cisplatin in Rats , 1999, Pharmaceutical Research.

[24]  J. A. Nelson,et al.  A transfected cell model for the renal toxin transporter, rOCT2. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  F. Maris,et al.  High-throughput solid-phase extraction for the determination of cimetidine in human plasma. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[26]  H. Koepsell,et al.  Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. , 1998, Biochemical and biophysical research communications.

[27]  G. Koren,et al.  Lack of cisplatin-ranitidine kinetic interactions: in vivo study in children, and in vitro study using dog renal brush border membrane vesicles. , 1998, Life Science.

[28]  F. Lang,et al.  Cloning and characterization of two human polyspecific organic cation transporters. , 1997, DNA and cell biology.

[29]  F. Lang,et al.  Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1 , 1996, FEBS letters.

[30]  T. Montine,et al.  Quiescent LLC-PK1 cells as a model for cis-diamminedichloroplatinum(II) nephrotoxicity and modulation by thiol rescue agents. , 1988, Cancer research.

[31]  N. Mulder,et al.  The protective potential of the combination of verapamil and cimetidine on cisplatin‐induced nephrotoxicity in man , 1987, Cancer.

[32]  J. Boyer,et al.  Isolated rat hepatocyte couplets in short‐term culture: Structural characteristics and plasma membrane reorganization , 1987, Hepatology.

[33]  A. Quebbemann,et al.  Protective effect of organic cation transport inhibitors on cis-diamminedichloroplatinum-induced nephrotoxicity. , 1984, The Journal of pharmacology and experimental therapeutics.

[34]  A. Somogyi,et al.  Clinical Pharmacokinetics of Cimetidine , 1983, Clinical pharmacokinetics.

[35]  P. Gill,et al.  Nonlinear renal clearance of ultrafilterable platinum in patients treated with cis-dichlorodiammineplatinum (II) , 2004, Cancer Chemotherapy and Pharmacology.

[36]  D. Townsend,et al.  Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. , 2003, Journal of the American Society of Nephrology : JASN.

[37]  W. Siffert,et al.  Enhanced G protein activation in IDDM patients with diabetic nephropathy , 1998, Diabetologia.