Effects of estrogen on learning-memory and expression of calbindin-D28K in hippocampus in vascular dementia rats.

Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca2+ in hippocampus was determined by Fura-2/AM fluorescence probe and the expression of Calbindin-D28K (CB) in hippocampal CA1 was tested by immunohistochemistry. Learning-memory ability was improved in E group rats; Concentration of Ca2+ in hippocampus was decreased in E group rats. The expression of CB was less in E group rats. It implies that estrogen could improve learning-memory ability in VD rats, which may be associated with suppressing intracellular Ca2+ overload and increasing the expression of CB in hippocampus.

[1]  Si-Qi Du,et al.  Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats , 2016, Neurochemistry International.

[2]  Midori Yoshida,et al.  A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats , 2016, PloS one.

[3]  Quan Xia,et al.  Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca(2+)-CaMKII-CREB pathway. , 2015, Chinese journal of natural medicines.

[4]  A. Roohbakhsh,et al.  Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats , 2015, Basic and clinical neuroscience.

[5]  P. Lein,et al.  Using the Morris Water Maze to Assess Spatial Learning and Memory in Weanling Mice , 2015, PloS one.

[6]  Huan Huang,et al.  Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia. , 2013, Molecular medicine reports.

[7]  F. Dong,et al.  Nimodipine Improves Regional Cerebral Blood Flow and Suppresses Inflammatory Factors in the Hippocampus of Rats with Vascular Dementia , 2012, The Journal of international medical research.

[8]  M. Martínez,et al.  Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain) , 2007, Dementia and Geriatric Cognitive Disorders.

[9]  J. J. Zarranz Imirizaldu,et al.  Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain) , 2007, Dementia and Geriatric Cognitive Disorders.

[10]  Rena Li,et al.  Estrogen and brain: synthesis, function and diseases. , 2005, Frontiers in bioscience : a journal and virtual library.

[11]  C. Nyakas,et al.  Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study. , 2005, Brain research.

[12]  M. Goldberg,et al.  Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators , 1997, The Journal of Neuroscience.

[13]  M E Greenberg,et al.  Calcium signaling in neurons: molecular mechanisms and cellular consequences. , 1995, Science.

[14]  R. Miller,et al.  Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones. , 1993, The Journal of physiology.

[15]  K. Baimbridge,et al.  Calcium-binding proteins in the nervous system , 1992, Trends in Neurosciences.

[16]  Richard J. Miller.  The control of neuronal Ca2+ homeostasis , 1991, Progress in Neurobiology.

[17]  D. Choi,et al.  Calcium and excitotoxic neuronal injury , 1991, Journal of the Neurological Sciences.