Sphingolipids in lung endothelial biology and regulation of vascular integrity.

[1]  S. Dudek,et al.  Role of FAK in S1P-regulated endothelial permeability. , 2012, Microvascular research.

[2]  J. Garcia,et al.  Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. , 2011, Cellular signalling.

[3]  R. Weichselbaum,et al.  Role of sphingolipids in murine radiation‐induced lung injury: protection by sphingosine 1‐phosphate analogs , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  M. Tölle,et al.  Pharmacological relevance and potential of sphingosine 1‐phosphate in the vascular system , 2011, British journal of pharmacology.

[5]  J. Garcia,et al.  Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase , 2011, PloS one.

[6]  J. Garcia,et al.  Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. , 2010, American journal of respiratory cell and molecular biology.

[7]  H. Fyrst,et al.  An update on sphingosine-1-phosphate and other sphingolipid mediators. , 2010, Nature chemical biology.

[8]  L. Obeid,et al.  Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. , 2010, Biochimie.

[9]  B. Levkau,et al.  Endothelial Functions of Sphingosine-1-phosphate , 2010, Cellular Physiology and Biochemistry.

[10]  F. Thol,et al.  Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1‐phosphate , 2010, Journal of cellular biochemistry.

[11]  J. Chun,et al.  Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. , 2010, American journal of respiratory cell and molecular biology.

[12]  S. Dudek,et al.  Synthetic Analogs of FTY720 [2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] Differentially Regulate Pulmonary Vascular Permeability in Vivo and in Vitro , 2009, Journal of Pharmacology and Experimental Therapeutics.

[13]  Jun Wada,et al.  Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. , 2009, Microvascular research.

[14]  X. Zheng,et al.  ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells , 2009, Circulation research.

[15]  S. Dudek,et al.  Regulation of vascular permeability by sphingosine 1-phosphate. , 2009, Microvascular research.

[16]  D. Vestweber,et al.  Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. , 2009, Trends in cell biology.

[17]  A. Kihara,et al.  Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. , 2008, Biochimica et biophysica acta.

[18]  R. Lal,et al.  Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. , 2008, Biophysical journal.

[19]  D. Vestweber,et al.  VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[20]  A. Melendez,et al.  Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine. , 2008, Reviews on recent clinical trials.

[21]  J. Parsons,et al.  Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase , 2007, The Journal of cell biology.

[22]  A. Malik,et al.  Dual Regulation of Endothelial Junctional Permeability , 2007, Science's STKE.

[23]  P. Vincent,et al.  Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase. , 2007, American journal of physiology. Cell physiology.

[24]  S. Dudek,et al.  Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. , 2007, Cellular signalling.

[25]  J. Garcia,et al.  Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. , 2007, American journal of respiratory cell and molecular biology.

[26]  A. Birukova,et al.  Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[27]  J. Garcia,et al.  Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells , 2007, Journal of Biological Chemistry.

[28]  J. Jacobson,et al.  Novel therapies for microvascular permeability in sepsis. , 2007, Current drug targets.

[29]  P. Gonzalez-Cabrera,et al.  Tipping the gatekeeper: S1P regulation of endothelial barrier function. , 2007, Trends in immunology.

[30]  M. Tani,et al.  Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. , 2007, Cellular signalling.

[31]  J. Bhattacharya,et al.  Resealing of endothelial junctions by focal adhesion kinase. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[32]  P. Bruni,et al.  Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. , 2006, Biochimica et biophysica acta.

[33]  Eugenia Wang,et al.  Dual Roles of Tight Junction-associated Protein, Zonula Occludens-1, in Sphingosine 1-Phosphate-mediated Endothelial Chemotaxis and Barrier Integrity* , 2006, Journal of Biological Chemistry.

[34]  R. Proia,et al.  Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. , 2006, The Biochemical journal.

[35]  Ian Parker,et al.  Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo , 2006, Nature chemical biology.

[36]  M. Lingen,et al.  Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. , 2006, Microvascular research.

[37]  B. Wojciak-Stothard,et al.  Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[38]  A. Malik,et al.  Signaling mechanisms regulating endothelial permeability. , 2006, Physiological reviews.

[39]  Mack H. Wu Endothelial focal adhesions and barrier function , 2005, The Journal of physiology.

[40]  S. Dudek,et al.  Regulation of sphingosine 1‐phosphate‐induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and α‐actinin , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  E. Goetzl,et al.  Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network , 2005, Nature Reviews Immunology.

[42]  J. Chun,et al.  S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  H. Riezman,et al.  The ins and outs of sphingolipid synthesis. , 2005, Trends in cell biology.

[44]  T. Karrison,et al.  Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans , 2005, Journal of clinical pharmacology.

[45]  A. Malik,et al.  Sphingosine 1-Phosphate-induced Mobilization of Intracellular Ca2+ Mediates Rac Activation and Adherens Junction Assembly in Endothelial Cells* , 2005, Journal of Biological Chemistry.

[46]  W. Erl,et al.  Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P1 Influences Multiple Functions of Human Endothelial Cells , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[47]  M. Pangalos,et al.  Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival , 2005, The Journal of Neuroscience.

[48]  D. A. Hanson,et al.  Focal adhesion kinase: in command and control of cell motility , 2005, Nature Reviews Molecular Cell Biology.

[49]  L. Obeid,et al.  Sphingosine-1-phosphate Signaling Promotes Critical Migratory Events in Vasculogenesis* , 2004, Journal of Biological Chemistry.

[50]  B. Simon,et al.  Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. , 2004, American journal of respiratory and critical care medicine.

[51]  R. Proia,et al.  Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. , 2004, Genes & development.

[52]  T. Hla Physiological and pathological actions of sphingosine 1-phosphate. , 2004, Seminars in cell & developmental biology.

[53]  F. Liu,et al.  Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho‐dependent mechanisms , 2004, Journal of cellular physiology.

[54]  J. Garcia,et al.  Endothelial cell barrier regulation by sphingosine 1‐phosphate , 2004, Journal of cellular biochemistry.

[55]  S. Salomone,et al.  Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. , 2004, Drug news & perspectives.

[56]  Elisabetta Dejana,et al.  Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. , 2004, Physiological reviews.

[57]  H. Rabb,et al.  Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. , 2004, American journal of respiratory and critical care medicine.

[58]  T. Hla,et al.  Point-Counterpoint of Sphingosine 1-Phosphate Metabolism , 2004, Circulation research.

[59]  R. Proia,et al.  Constitutive expression of the S1P1 receptor in adult tissues. , 2004, Prostaglandins & other lipid mediators.

[60]  R. Gosens,et al.  Role of Rho-kinase in maintaining airway smooth muscle contractile phenotype. , 2004, European journal of pharmacology.

[61]  A. Verin,et al.  Involvement of site‐specific FAK phosphorylation in sphingosine‐1 phosphate‐ and thrombin‐induced focal adhesion remodeling: role of Src and GIT , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[62]  S. Spiegel,et al.  Sphingosine‐1‐phosphate stimulates contraction of human airway smooth muscle cells , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[63]  Sarah Spiegel,et al.  Sphingosine-1-phosphate: an enigmatic signalling lipid , 2003, Nature Reviews Molecular Cell Biology.

[64]  T. Tanita,et al.  Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase* , 2003, The Journal of Biological Chemistry.

[65]  J. Garcia,et al.  S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. , 2003, Journal of applied physiology.

[66]  Susan Summers,et al.  Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin. , 2002, American journal of physiology. Cell physiology.

[67]  E. Van Obberghen-Schilling,et al.  Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. , 2002, Journal of cell science.

[68]  Michael D. Davis,et al.  The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors* , 2002, The Journal of Biological Chemistry.

[69]  P. Mcglynn,et al.  Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. , 2002, Experimental cell research.

[70]  A. Malik,et al.  Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function , 2002, The Journal of physiology.

[71]  O. Matsui,et al.  Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells , 2002, Circulation research.

[72]  J. P. Hobson,et al.  EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[73]  A. Verin,et al.  Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. , 2001, The Journal of clinical investigation.

[74]  Keith Burridge,et al.  RhoA is required for monocyte tail retraction during transendothelial migration , 2001, The Journal of cell biology.

[75]  A. Verin,et al.  Differential Regulation of Sphingosine-1-phosphate-and Vegf-induced Endothelial Cell Chemotaxis Involvement of G I ␣ 2 -linked Rho Kinase Activity We Compared Stimulus-coupling Pathways Involved in Bovine Pulmonary Artery (pa) and Lung Microvascular Endothelial Cell Migration Evoked by Sphingosine-1 , 2022 .

[76]  D. Brindley,et al.  Platelet-released phospholipids link haemostasis and angiogenesis. , 2001, Cardiovascular research.

[77]  T. Ohmori,et al.  G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. , 2001, The Journal of biological chemistry.

[78]  J. P. Hobson,et al.  Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. , 2000, The Journal of clinical investigation.

[79]  G. Pendl,et al.  Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. , 2000, The Journal of biological chemistry.

[80]  T. Ohmori,et al.  Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. , 2000, Journal of biochemistry.

[81]  S. Narumiya,et al.  Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop* , 2000, The Journal of Biological Chemistry.

[82]  E. Howard,et al.  Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. , 2000, Experimental cell research.

[83]  T. Bleu,et al.  Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5* , 2000, The Journal of Biological Chemistry.

[84]  Y. Yatomi,et al.  Metabolism and functional effects of sphingolipids in blood cells , 1999, British journal of haematology.

[85]  K. Claffey,et al.  Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate , 1999, Cell.

[86]  M. Corada,et al.  Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[87]  P. Carmeliet,et al.  Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis , 1999, Cell.

[88]  E. Salmon,et al.  Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts , 1999, Nature Cell Biology.

[89]  C. H. Liu,et al.  Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. , 1998, Science.

[90]  Ingrid,et al.  Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. , 1998, The Biochemical journal.

[91]  M. K. Magnússon,et al.  Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction. , 1997, Molecular biology of the cell.

[92]  S. Narumiya,et al.  Rho effectors and reorganization of actin cytoskeleton , 1997, FEBS letters.

[93]  Yoshiharu Matsuura,et al.  Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)* , 1996, The Journal of Biological Chemistry.

[94]  T. Hla,et al.  The Inducible G Protein-coupled Receptor edg-1 Signals via the G/Mitogen-activated Protein Kinase Pathway (*) , 1996, The Journal of Biological Chemistry.

[95]  S. Hakomori,et al.  Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. , 1995, Blood.

[96]  M. Itoh,et al.  Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions , 1994, The Journal of cell biology.

[97]  R. Wysolmerski,et al.  Involvement of myosin light-chain kinase in endothelial cell retraction. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[98]  P. Boschetto,et al.  Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo. , 1989, Journal of pharmacological methods.