Are vestibular hair cells excited to death by aminoglycoside antibiotics?

Aminoglycoside antibiotics are commonly prescribed throughout the world for the treatment of serious gram-negative bacterial infections. However, their use is limited by nephrotoxicity and ototoxicity. Although the traditional explanation for their ototoxicity in cochlear and vestibular hair cells has been the inhibition of mitochondrial protein synthesis, evidence is accumulating to suggest that many aminoglycosides cause excitotoxicity in hair cells as a result of their agonist action at the polyamine site on the N- methyl-D-aspartate (NMDA) receptor. The aim of this minireview is to summarise and critically evaluate this evidence and to consider the therapeutic implications of this hypothesis.

[1]  T. Yamakura,et al.  Subunit- and site-specific pharmacology of the NMDA receptor channel , 1999, Progress in Neurobiology.

[2]  W. Tate,et al.  Rapid identification of an A1555G mutation in human mitochondrial DNA implicated in aminoglycoside-induced ototoxicity , 1999, Journal of Human Genetics.

[3]  C. Parsons,et al.  Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data , 1999, Neuropharmacology.

[4]  Y. Nakai,et al.  Involvement of nitric oxide in aminoglycoside vestibulotoxicity in guinea pigs , 1999, Neuroscience Letters.

[5]  Alan M. Brichta,et al.  Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats , 1999, Neuroscience Letters.

[6]  P. Skolnick,et al.  Aminoglycoside neurotoxicity involves NMDA receptor activation , 1999, Brain Research.

[7]  Y. Masuda,et al.  4-methylcatechol, a potent inducer of nerve growth factor synthesis, protects spiral ganglion neurons from aminoglycoside ototoxicity--preliminary report. , 1999, Acta oto-laryngologica. Supplementum.

[8]  J. Schacht,et al.  Are aminoglycoside antibiotics excitotoxic? , 1998, Neuroreport.

[9]  Masahiro Takahashi,et al.  The role of N-methyl-d-asparate receptor in the guinea pig inner ear after unilateral labyrinthectomy , 1998, Neuroscience Letters.

[10]  Andrew Forge,et al.  Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs , 1998, The Journal of comparative neurology.

[11]  J. Schacht.  Aminoglycoside Ototoxicity: Prevention in Sight? , 1998, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[12]  P. Skolnick,et al.  Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors. , 1998, European journal of pharmacology.

[13]  Y. Nakai,et al.  Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. , 1998, Acta oto-laryngologica. Supplementum.

[14]  A. Forge,et al.  Apoptotic death of hair cells , 1997 .

[15]  C. Berlin,et al.  N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss , 1996, Nature Medicine.

[16]  C. Darlington,et al.  Recent advances in the pharmacology of the vestibulo-ocular reflex system. , 1996, Trends in pharmacological sciences.

[17]  Barbara Canlon,et al.  Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3 , 1996, Nature Medicine.

[18]  B Malgrange,et al.  NT‐3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells , 1996, Neuroreport.

[19]  M. Barclay,et al.  A suggested approach to once-daily aminoglycoside dosing. , 1995, British journal of clinical pharmacology.

[20]  G. Cortopassi,et al.  Proposed molecular and cellular mechanism for aminoglycoside ototoxicity , 1994, Antimicrobial Agents and Chemotherapy.

[21]  L. Pullan,et al.  Neomycin Is an Agonist at a Polyamine Site on the N‐Methyl‐D‐Aspartate Receptor , 1992, Journal of neurochemistry.

[22]  R. Vega,et al.  Streptomycin blocks the postsynaptic effects of excitatory amino acids on the vestibular system primary afferents , 1991, Brain Research.

[23]  L. Pullan,et al.  The inhibition of [125I]ω-conotoxin GVIA binding to neuronal membranes by neomycin may be mediated by a GTP-binding protein , 1991 .