Quantification of 3-D coronary arterial motion using clinical biplane cineangiograms

Speculation that the motion of the coronary arteries might be involved in the pathogenesis of coronary atherosclerosis has generated growing interest in the study of this motion. Accordingly, a system has been developed to quantify 3-D coronary arterial motion using clinical biplane cineangiograms. Exploiting the temporal continuity of sequential angiographic images, a template matching technique is designed to track the non-uniform frame-to-frame motion of coronary arteries without assuming that the vessels experience uniform axial strain. The implementation of the system is automated by a coarse-to-fine matching process, thus improving the efficiency and objectivity of motion analysis. The system has been validated and employed to characterize the in vivo motion dynamics of human coronary arteries; illustrative results show that this system is a promising tool for routine clinical and laboratory analysis of coronary arterial motion.