Analysis of dynamic contrast enhanced MRI.

The advances in MRI image acquisition have led to the increasing use of parametric or calculated images, which are designed to display physiological features of tissues rather than simply anatomical structure. One common type of dynamic imaging data is produced when rapidly repeated sequential imaging sequences are performed during injection of an intravenous contrast media [1–8]. Although many of the applications of dynamic contrast enhanced imaging were developed using MRI in the brain they are now being commonly applied using both MRI and CT. These techniques now have both research and clinical applications throughout the body and in many types of pathological tissue. In this article we will describe the analysis techniques which can be applied to dynamic contrast enhanced data. We will start with the specific application of dynamic susceptibility contrast imaging of perfusion using MRI (DSC-MRI) since a number of technical aspects of the data collection and analysis are unique to this approach. We will then discuss the techniques available for the analysis of dynamic relaxivity contrast enhanced MRI (DRC-MRI), which are also directly applicable to dynamic contrast enhanced CT data.

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