Distribution of Calcium/Creatinine Ratio in Pregnancy Induced Hypertension

In pregnancy induced hypertension (PIH) hypocalciuria has been demonstrated from 24 hour urine collections. This method of detection of hypocalciuria is difficult and tedious in clinical practice. In this study, the calcium/creatinine ratio was analysed from a random single urine sample in 20 normotensive, 20 proteinuric PIH and 37 non-proteinuric PIH women. A significantly lower calcium/creatinine ratio was demonstrated in proteinuric PIH in contrast to normotensive and non-proteinuric PIH patients (p<0.001). The calcium/creatinine ratio correlated negatively (r–−0.33; p<0.01) with the albumin/creatinine ratio. There was no correlation between the calcium/creatinine ratio and platelet count, urate or birthweight centile.