A Genetic-Fuzzy System Approach to Control a Model of the HIV Infection Dynamics

This paper presents a genetic fuzzy system approach to control a nonlinear dynamic model of the HIV infection. The system is conceived to find mamdani fuzzy controllers that are capable of boosting the immune response while reducing the impact on the body because of the use of potentially toxic medicaments. General aspects of the used approach are described while special emphasis is given to the evolutionary mechanism. The best solution found from several evolutionary runs is analyzed in terms of control and interpretability issues.

[1]  Li-Xin Wang,et al.  A Course In Fuzzy Systems and Control , 1996 .

[2]  Xiaohua Xia,et al.  When to initiate HIV therapy: a control theoretic approach , 2003, IEEE Transactions on Biomedical Engineering.

[3]  I. Craig,et al.  Can HIV/AIDS be controlled? Applying control engineering concepts outside traditional fields , 2005, IEEE Control Systems.

[4]  Guanrong Chen,et al.  Feedback control of a biodynamical model of HIV-1 , 2001, IEEE Transactions on Biomedical Engineering.

[5]  Tong Heng Lee,et al.  Multiobjective Evolutionary Algorithms and Applications , 2005, Advanced Information and Knowledge Processing.

[6]  H. Ishibuchi Genetic fuzzy systems: evolutionary tuning and learning of fuzzy knowledge bases , 2004 .

[7]  B. Adams,et al.  HIV dynamics: Modeling, data analysis, and optimal treatment protocols , 2005 .

[8]  Frank Hoffmann,et al.  Evolutionary algorithms for fuzzy control system design , 2001, Proc. IEEE.

[9]  Yi-Sheng Zhou,et al.  Optimal design for fuzzy controllers by genetic algorithms , 2000 .

[10]  Carlos Andrés Peña-Reyes,et al.  Coevolutionary Fuzzy Modeling , 2004, Lecture Notes in Computer Science.

[11]  Peña Reyes,et al.  Coevolutionary Fuzzy Modeling , 2004, Lecture Notes in Computer Science.

[12]  Alan S. Perelson,et al.  Mathematical Analysis of HIV-1 Dynamics in Vivo , 1999, SIAM Rev..

[13]  Xiaohua Xia,et al.  Introducing HIV/AIDS education into the electrical engineering curriculum at the University of Pretoria , 2004, IEEE Transactions on Education.

[14]  Robert T. Schooley,et al.  Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. U.S. Department of Health and Human Services (DHHS). , 1997, BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation.

[15]  J. J. Henning,et al.  Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents, January 28, 2000 , 1998, HIV clinical trials.

[16]  Hem Raj Joshi,et al.  Optimal control of an HIV immunology model , 2002 .

[17]  Denise E. Kirschner,et al.  Using Mathematics to Understand HIV Immune Dynamics , 1997 .

[18]  Shuzhi Sam Ge,et al.  Nonlinear control of a dynamic model of HIV-1 , 2005, IEEE Transactions on Biomedical Engineering.