论文信息 - Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surface coated with polyaspartic acid

Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surface coated with polyaspartic acid

In this study, some biological tests were carried out with a magnetic fluid (MF) sample based on magnetite nanoparticles (MNPs) surface coated with polyaspartic acid (PAMF). The tests were performed from 1 to 30 days after injection of 50 μL of PAMF in Swiss mice. The PAMF biocompatibility/toxicity was evaluated through cytometry, micronuclei assay, and morphology of several organs. All observed results were time and dose dependent. The data indicate that MNPs surface-treated with polyaspartic acid may be considered as a potential precursor of anticancer drugs.

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