Assessment of Risk Factors and Clinical Importance of Enlarged Perivascular Spaces by Whole-Brain Investigation in the Multi-Ethnic Study of Atherosclerosis

Key Points Question What is the clinical importance of enlarged perivascular spaces detected on brain magnetic resonance imaging? Findings This cross-sectional study was conducted in a multiethnic sample of 1026 individuals living in the community. Enlarged perivascular spaces in the basal ganglia and thalamus were associated with magnetic resonance imaging markers of cerebral small-vessel disease. Meaning The findings of this study suggest a high burden of enlarged perivascular spaces in the basal ganglia and thalamus may represent underlying vascular brain pathology.

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