Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water

A neutral and efficient one-pot three-component aqueous-phase synthesis is developed for various spirooxindole derivatives from isatin, malononitrile, and 1,3-dicarbonyl compounds in high yields by...

[1]  C. Yao,et al.  Fluoride ion catalyzed multicomponent reactions for efficient synthesis of 4H-chromene and N-arylquinoline derivatives in aqueous media , 2008 .

[2]  V. Kumar,et al.  Novel Aqueous Phase Supramolecular Synthesis of 3‐Pyrrolylindolin‐2‐ones and Pyrrolylindeno[1,2‐b]quinoxalines , 2008 .

[3]  S. Ji,et al.  A simple and clean procedure for three-component synthesis of spirooxindoles in aqueous medium , 2007 .

[4]  P. T. Perumal,et al.  A new InCl3-catalyzed, facile and efficient method for the synthesis of spirooxindoles under conventional and solvent-free microwave conditions , 2007 .

[5]  V. Kumar,et al.  Supramolecular synthesis of selenazoles using selenourea in water in the presence of beta-cyclodextrin under atmospheric pressure. , 2007, The Journal of organic chemistry.

[6]  Ruby Singh,et al.  Multicomponent One-pot Diastereoselective Synthesis of Biologically Important Scaffold under Microwaves , 2006 .

[7]  Meng‐Yang Chang,et al.  Synthesis of (′)-coerulescine and a formal synthesis of (′)-horsfiline , 2005 .

[8]  P. Baran,et al.  Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G. , 2005, Journal of the American Chemical Society.

[9]  K. R. Rao,et al.  Aqueous phase synthesis of thiazoles and aminothiazoles in the presence of β-cyclodextrin , 2005 .

[10]  Yi‐hong Ding,et al.  High Chiral Discrimination of 2,2′-Ditellurobis(2-deoxy-β-cyclodextrin) in Recognition of Dansyl-D/L-phenylalanine , 2005 .

[11]  K. R. Rao,et al.  Study of the Michael addition of beta-cyclodextrin-thiol complexes to conjugated alkenes in water. , 2005, Chemical communications.

[12]  J. Deschamps,et al.  A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor. , 2004, Journal of medicinal chemistry.

[13]  R. Breslow.  Determining the geometries of transition States by use of antihydrophobic additives in water. , 2004, Accounts of chemical research.

[14]  K. R. Rao,et al.  Mild oxidation of alcohols with o-iodoxybenzoic acid (IBX) in water/acetone mixture in the presence of beta-cyclodextrin. , 2003, The Journal of organic chemistry.

[15]  J. Nagamine,et al.  Oxindole derivatives as orally active potent growth hormone secretagogues. , 2001, Journal of medicinal chemistry.

[16]  L. Ilharco,et al.  Characterization of Solid Complexes between Aromatic Ketones and β-Cyclodextrin Using Diffuse Reflectance Infrared Fourier Transform Spectroscopy , 2000 .

[17]  S. Hilton,et al.  A new route to spirooxindoles. , 2000, Organic letters.

[18]  N. Rosen,et al.  Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues , 1999 .

[19]  H. Schneider,et al.  NMR Studies of Cyclodextrins and Cyclodextrin Complexes. , 1998, Chemical reviews.

[20]  Ronald Breslow,et al.  Hydrophobic Effects on Simple Organic Reactions in Water , 1991 .

[21]  K. Joshi,et al.  SPIRO HETEROCYCLES. XIX, SYNTHESIS AND INSECTICIDAL ACTIVITY OF SOME NEW FLUORINE-CONTAINING SPIRO 4H-1-BENZO-PYRAN-4,3'-3H-INDOLE-3-CARBONITRILES/CAR BOXYETHYLESTERS , 1990 .

[22]  A. Dandia,et al.  Studies in spiroheterocycles. Part XVII. synthesis of novel fluorine containing spiro[indole-pyranobenzopyran] and spiro[indenopyran-indole] derivatives , 1989 .

[23]  J. Hieble,et al.  4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist. , 1985, Journal of medicinal chemistry.

[24]  Y. Iitaka,et al.  Isolation and structure determination of a new marine toxin, neosurugatoxin, from the Japanese Ivory Shell, . , 1981 .

[25]  Ronald Breslow,et al.  Hydrophobic acceleration of Diels-Alder reactions , 1980 .