II. Sister chromatid exchanges

Summary. In the lymphocytes of heterozygous carriers of the rare autosomal fragile site (16)(q22) an exceptionally high frequency of sister chromatid exchanges was demonstrated at the induced fragile site by means of simultaneous berenil and BrdU treatment of the cultures. The rate of sister chromatid exchanges at q22 is also increased in the fragile chromosome 16 by treating the cells with BrdU alone. The possible reasons for the preferential occurrence of induced and spontaneous sister chromatid exchanges at fra (16)(q22) are discussed.

[1]  J. B. Rattner,et al.  An investigation of human sperm pronuclear chromosome "gaps" using scanning electron microscopy. , 1986, Cytogenetics and cell genetics.

[2]  A. Carrano,et al.  Determination of the baseline sister chromatid exchange frequency in human and mouse peripheral lymphocytes using monoclonal antibodies and very low doses of bromodeoxyuridine. , 1986, Cytogenetics and cell genetics.

[3]  G. Sutherland,et al.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12. , 1984, American journal of human genetics.

[4]  C. Harrison,et al.  The fragile X: a scanning electron microscope study. , 1983, Journal of medical genetics.

[5]  G. Croci.  BrdU-sensitive fragile site on long arm of chromosome 16. , 1983, American journal of human genetics.

[6]  R. Painter.  A replication model for sister-chromatid exchange. , 1980, Mutation research.

[7]  Chung-Cheng Liu,et al.  Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break , 1980, Cell.

[8]  A. Krey.  Non-Intercalative Binding to DNA , 1980 .

[9]  S. Wolff,et al.  New Giemsa method for the differential staining of sister chromatids , 1974, Nature.

[10]  S. Latt.  Localization of Sister Chromatid Exchanges in Human Chromosomes , 1974, Science.

[11]  E. Delain,et al.  Mécanisme d'action des diamidines trypanocides. Importance de la composition en bases dans l'association berenil-polynucléotides. , 1970 .