Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin

[1]  R. Chapkin,et al.  Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk. , 2022, The FEBS journal.

[2]  R. Chapkin,et al.  Personalized Nutrition Using Microbial Metabolite Phenotype to Stratify Participants and Non-Invasive Host Exfoliomics Reveal the Effects of Flaxseed Lignan Supplementation in a Placebo-Controlled Crossover Trial , 2022, Nutrients.

[3]  L. B. Case.  Membranes regulate biomolecular condensates , 2022, Nature Cell Biology.

[4]  P. Tompa,et al.  The role of ordered cooperative assembly in biomolecular condensates , 2021, Nature Reviews Molecular Cell Biology.

[5]  T. Lee,et al.  The Pivotal Role of the Dysregulation of Cholesterol Homeostasis in Cancer: Implications for Therapeutic Targets , 2020, Cancers.

[6]  J. Yi,et al.  Apolipoproteins and cancer , 2019, Cancer medicine.

[7]  C. Ireson,et al.  The role of mouse tumour models in the discovery and development of anticancer drugs , 2019, British Journal of Cancer.

[8]  L. Selvaratnam,et al.  The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review , 2019, Journal of oncology.

[9]  R. Coffey,et al.  APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. , 2018, Developmental cell.

[10]  Y. Jan,et al.  Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F , 2018, Proceedings of the National Academy of Sciences.

[11]  Anna L. Duncan,et al.  Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes , 2017, Scientific Reports.

[12]  H. Clevers,et al.  Cancer stem cells revisited , 2017, Nature Medicine.

[13]  M. Pasenkiewicz-Gierula,et al.  High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review , 2017, Cell Biochemistry and Biophysics.

[14]  Jie J. Zheng,et al.  Modulating the wnt signaling pathway with small molecules , 2017, Protein science : a publication of the Protein Society.

[15]  J. Fernandez-Checa,et al.  MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content , 2017, Redox biology.

[16]  K. Ueda,et al.  Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol. , 2017, Nature chemical biology.

[17]  Emma M Schatoff,et al.  WNT Signaling and Colorectal Cancer , 2017, Current Colorectal Cancer Reports.

[18]  Bruce Posner,et al.  Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer , 2016, Science Translational Medicine.

[19]  Hans Clevers,et al.  Modeling Development and Disease with Organoids , 2016, Cell.

[20]  R. Fodde,et al.  High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells , 2016, Stem cell reports.

[21]  A. Azmi,et al.  Cancer prevention and therapy through the modulation of the tumor microenvironment. , 2015, Seminars in cancer biology.

[22]  Takanori Kanai,et al.  Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids , 2015, Nature Medicine.

[23]  Hongbin Ji,et al.  Regulation of EGFR nanocluster formation by ionic protein-lipid interaction , 2014, Cell Research.

[24]  Junsang Doh,et al.  Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling , 2014, Nature Communications.

[25]  A. VanHook.  Enhancing Wnt Signaling in Rafts , 2013, Science Signaling.

[26]  A. Periasamy,et al.  Förster resonance energy transfer microscopy and spectroscopy for localizing protein–protein interactions in living cells , 2013, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[27]  Michael Kühl,et al.  Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. , 2013, Developmental cell.

[28]  J. Dinić,et al.  Actin filaments attachment at the plasma membrane in live cells cause the formation of ordered lipid domains. , 2013, Biochimica et biophysica acta.

[29]  X. Zhuang,et al.  Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes , 2013, The Journal of cell biology.

[30]  Xi He,et al.  Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. , 2012, Cold Spring Harbor perspectives in biology.

[31]  H. Clevers,et al.  Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. , 2012, Gastroenterology.

[32]  D. Richards,et al.  Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane , 2012, Biology Open.

[33]  Mark Bates,et al.  Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging , 2011, Nature Methods.

[34]  L. Rahme,et al.  Drosophila melanogaster as a model for human intestinal infection and pathology , 2011, Disease Models & Mechanisms.

[35]  Jian Dai,et al.  Instability of cholesterol clusters in lipid bilayers and the cholesterol's Umbrella effect. , 2010, The journal of physical chemistry. B.

[36]  H. Krause,et al.  The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. , 2009, Genes & development.

[37]  Mark Peifer,et al.  Wnt signaling from development to disease: insights from model systems. , 2009, Cold Spring Harbor perspectives in biology.

[38]  Pamela S. Robinson,et al.  Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[39]  Gordon K. Smyth,et al.  Testing significance relative to a fold-change threshold is a TREAT , 2009, Bioinform..

[40]  R. Challiss,et al.  Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons1 , 2008, Journal of neurochemistry.

[41]  A. Gorfe,et al.  Ras nanoclusters: molecular structure and assembly. , 2007, Seminars in cell & developmental biology.

[42]  Wynne Peterson-Nedry,et al.  Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP. , 2007, Developmental biology.

[43]  P. Kabouridis.  Lipid rafts in T cell receptor signalling (Review) , 2006 .

[44]  Barbara Baird,et al.  Visualization of plasma membrane compartmentalization with patterned lipid bilayers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Taketo.  Shutting down Wnt signal–activated cancer , 2004, Nature Genetics.

[46]  R. Fodde,et al.  The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. , 2002, Human molecular genetics.

[47]  H. Kashihara,et al.  Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. , 1998, International journal of epidemiology.