Small intestine remodeling in male Goto–Kakizaki rats

Obesity is associated with the development of insulin resistance (IR) and type‐2 diabetes mellitus (T2DM); however, not all patients with T2DM are obese. The Goto–Kakizaki (GK) rat is an experimental model of spontaneous and non‐obese T2DM. There is evidence that the intestine contributes to IR development in GK animals. This information prompted us to investigate small intestine remodeling in this animal model.

[1]  L. Forney,et al.  High‐fat diet–induced alterations to gut microbiota and gut‐derived lipoteichoic acid contributes to the development of enteric neuropathy , 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[2]  Jianhua Huang,et al.  Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats , 2020, Frontiers in Microbiology.

[3]  Jieyun Yin,et al.  Intestinal electrical stimulation attenuates hyperglycemia and prevents loss of pancreatic β cells in type 2 diabetic Goto–Kakizaki rats , 2019, Nutrition & Diabetes.

[4]  A. R. Trevizan,et al.  Acute Toxoplasma gondii infection alters the number of neurons and the proportion of enteric glial cells in the duodenum in Wistar rats , 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[5]  Sara Larsson,et al.  Neuroprotective effects of vitamin D on high fat diet- and palmitic acid-induced enteric neuronal loss in mice , 2018, BMC Gastroenterology.

[6]  M. Natali,et al.  Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  M. Nakata,et al.  Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats , 2018, Neuropeptides.

[8]  R. Curi,et al.  Comparison of Goto-Kakizaki rats and high fat diet-induced obese rats: Are they reliable models to study Type 2 Diabetes mellitus? , 2017, PloS one.

[9]  N. Bódi,et al.  Region-dependent effects of diabetes and insulin-replacement on neuronal nitric oxide synthase- and heme oxygenase-immunoreactive submucous neurons , 2017, World journal of gastroenterology.

[10]  R. Curi,et al.  Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice , 2017, Scientific Reports.

[11]  X. Terra,et al.  A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats , 2017, British Journal of Nutrition.

[12]  J. Tack,et al.  Fructose consumption impairs serotonergic signaling in the murine enteric nervous system , 2016, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[13]  R. Curi,et al.  Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? , 2016, Analytical biochemistry.

[14]  M. Góis,et al.  Chronic infection with Toxoplasma gondii induces death of submucosal enteric neurons and damage in the colonic mucosa of rats. , 2016, Experimental parasitology.

[15]  D. DuBois,et al.  Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats , 2015, Gene regulation and systems biology.

[16]  J. Worthington.  The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease , 2015, Biochemical Society transactions.

[17]  K. Clément,et al.  Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling. , 2015, Cell metabolism.

[18]  F. Servant,et al.  The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease. , 2015, Cell metabolism.

[19]  P. Correia‐de‐Sá,et al.  The Effect of Ischemia and Reperfusion on Enteric Glial Cells and Contractile Activity in the Ileum , 2015, Digestive Diseases and Sciences.

[20]  V. Nosikov,et al.  The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients , 2015, Cell Biochemistry and Biophysics.

[21]  J. Chen,et al.  Hyperglycemia‐induced small intestinal dysrhythmias attributed to sympathovagal imbalance in normal and diabetic rats , 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[22]  M. Dailey.  Nutrient-induced intestinal adaption and its effect in obesity , 2014, Physiology & Behavior.

[23]  S. R. Stabille,et al.  Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats. , 2014, Anais da Academia Brasileira de Ciencias.

[24]  F. Rubino,et al.  Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion , 2014, Diabetes.

[25]  M. Blennerhassett,et al.  Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ , 2014, Journal of cellular and molecular medicine.

[26]  D. R. Linden,et al.  Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats. , 2013, World journal of gastroenterology.

[27]  H. Gregersen,et al.  Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats--is it related to advanced glycation end product formation? , 2013, Journal of biomechanics.

[28]  J. Zanoni,et al.  Neuroprotective Effect of Quercetin on the Duodenum Enteric Nervous System of Streptozotocin-Induced Diabetic Rats , 2012, Digestive Diseases and Sciences.

[29]  S. R. Stabille,et al.  Effect of caloric restriction on myenteric neuroplasticity in the rat duodenum during aging , 2012, Autonomic Neuroscience.

[30]  J. Lincoln,et al.  Selective responses of myenteric neurons to oxidative stress and diabetic stimuli , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[31]  D. DuBois,et al.  Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats , 2011, Molecular and Cellular Endocrinology.

[32]  D. DuBois,et al.  Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats , 2011, PloS one.

[33]  S. Srinivasan,et al.  Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[34]  S. Shoelson,et al.  Type 2 diabetes as an inflammatory disease , 2011, Nature Reviews Immunology.

[35]  M. Suárez-Fariñas,et al.  Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. , 2011, The American journal of clinical nutrition.

[36]  C. Jobin,et al.  High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse , 2010, PloS one.

[37]  S. Sørensen,et al.  Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults , 2010, PloS one.

[38]  J. Tanti,et al.  Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. , 2009, Current opinion in pharmacology.

[39]  S. Ito,et al.  Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin‐1β from enteric glial cells , 2009, Journal of neuroscience research.

[40]  H. Bramlett,et al.  Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[41]  A. Goldfine,et al.  Getting away from glucose: fanning the flames of obesity-induced inflammation , 2009, Nature Medicine.

[42]  A. Thomson,et al.  Morphological, kinetic, membrane biochemical and genetic aspects of intestinal enteroplasticity. , 2009, World journal of gastroenterology.

[43]  A. Avogaro,et al.  The metabolic syndrome, diabetes and lung dysfunction. , 2008, Diabetes & metabolism.

[44]  E. Feldman,et al.  Mechanisms of disease: The oxidative stress theory of diabetic neuropathy , 2008, Reviews in Endocrine and Metabolic Disorders.

[45]  David R. Jacobs,et al.  Periodontal Disease and Incident Type 2 Diabetes , 2008, Diabetes Care.

[46]  P. Brunetti.  The lean patient with type 2 diabetes: characteristics and therapy challenge. , 2007 .

[47]  W. Shehee,et al.  The relationship between the effects of short‐chain fatty acids on intestinal motility in vitro and GPR43 receptor activation , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[48]  K. Fujiwara,et al.  Young Adult‐Specific Hyperphagia in Diabetic Goto‐Kakizaki Rats is Associated with Leptin Resistance and Elevation of Neuropeptide Y mRNA in the Arcuate Nucleus , 2006, Journal of neuroendocrinology.

[49]  A. Syrenicz,et al.  Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents. , 2006, Neuro endocrinology letters.

[50]  S. Akira,et al.  Activation of smooth muscle and myenteric plexus cells of jejunum via toll‐like receptor 4 , 2006, Journal of cellular physiology.

[51]  A. Drewes,et al.  Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. , 2006, World journal of gastroenterology.

[52]  G. Brandi,et al.  Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease , 2005, The American Journal of Gastroenterology.

[53]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[54]  R. Ferraris,et al.  Intestinal transport during fasting and malnutrition. , 2003, Annual review of nutrition.

[55]  H. Gregersen,et al.  Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats , 2003, Diabetologia.

[56]  K. Tsuda,et al.  Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats. , 2003, Endocrine journal.

[57]  L. Hernandes,et al.  Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid. , 2002, Arquivos de neuro-psiquiatria.

[58]  R. Gaynor,et al.  Role of the NF-kappaB pathway in the pathogenesis of human disease states. , 2001, Current molecular medicine.

[59]  T. Aw,et al.  Suppression of apoptosis is responsible for increased thickness of intestinal mucosa in streptozotocin-induced diabetic rats. , 2001, Metabolism: clinical and experimental.

[60]  B. Portha,et al.  Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat. , 1996, The American journal of physiology.

[61]  J. Galmiche,et al.  Inhibition of acetylcholine induced intestinal motility by interleukin 1 beta in the rat. , 1996, Gut.

[62]  M. Derouet,et al.  Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver. , 1993, The American journal of physiology.

[63]  M. Bennett,et al.  Cultured sympathetic neurons synthesize and release the cytokine interleukin 1 beta. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[64]  J. Kalbfleisch,et al.  Structural and functional characteristics of muscle from diabetic rodent small intestine. , 1990, The American journal of physiology.

[65]  D G Altman,et al.  Analysis of serial measurements in medical research. , 1990, BMJ.

[66]  Barbosa Aj.  [Histological technique for intramural ganglia in thick tissue preparation (author's transl)]. , 1978 .

[67]  J. W. Osborne,et al.  Proliferation rate and transit time of mucosal cells in small intestine of the diabetic rat. , 1977, Gastroenterology.

[68]  B. Portha,et al.  The GK rat: a prototype for the study of non-overweight type 2 diabetes. , 2012, Methods in molecular biology.

[69]  T. Mayhew,et al.  Number and ultrastructure of epithelial cells in crypts and villi along the streptozotocin-diabetic small intestine: a quantitative study on the effects of insulin and aldose reductase inhibition , 2004, Virchows Archiv.

[70]  C. Östenson,et al.  Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat , 2004, Diabetologia.

[71]  E. Boyko,et al.  Type 2 diabetes prevalence in Asian Americans: results of a national health survey. , 2004, Diabetes care.

[72]  A. Spångeus,et al.  Myenteric plexus of obese diabetic mice (an animal model of human type 2 diabetes). , 2001, Histology and histopathology.

[73]  Y. Gotō,et al.  Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats , 1975 .

[74]  A. Godzik,et al.  from in the Gut , 2016 .