Recent developments on BMPs and their antagonists in inflammatory bowel diseases

[1]  Tomohiro Mizutani,et al.  Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment , 2023, Journal of Gastroenterology.

[2]  N. Kamada,et al.  Inflammatory bowel disease and carcinogenesis , 2022, Cancer and Metastasis Reviews.

[3]  Junji Xu,et al.  Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3 , 2021, Frontiers in cell and developmental biology.

[4]  D. Winton,et al.  Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration , 2021, Gastroenterology.

[5]  W. Boesmans,et al.  The enteric nervous system in gastrointestinal disease etiology , 2021, Cellular and Molecular Life Sciences.

[6]  Sigita Malijauskaite,et al.  Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms. , 2021, Cytokine & growth factor reviews.

[7]  E. Fiebiger,et al.  Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids , 2021, Frontiers in Immunology.

[8]  W. Koltun,et al.  Impairment of tissue resident mesenchymal stem cells in chronic ulcerative colitis and Crohn's disease. , 2021, Journal of Crohn's & colitis.

[9]  Hui-Jane Chen,et al.  CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP‐9/PI3K/AKT pathway , 2020, Cell biology international.

[10]  J. Hasty,et al.  The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis. , 2020, Gastroenterology.

[11]  S. Ylä-Herttuala,et al.  BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF , 2020, Angiogenesis.

[12]  Jingxin Li,et al.  Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells , 2020, Stem cell reports.

[13]  S. Svegliati,et al.  Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease-associated spondyloarthritis. , 2020, Rheumatology.

[14]  Jie-shou Li,et al.  Follistatin like protein-1 modulates macrophage polarization and aggravates dextran sodium sulfate-induced colitis. , 2020, International immunopharmacology.

[15]  Yongchun Zhang,et al.  BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract. , 2020, Annual review of physiology.

[16]  Li-Xuan Ding,et al.  Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling , 2019, Genes & diseases.

[17]  W. Geng,et al.  BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways , 2019, Journal of Experimental & Clinical Cancer Research.

[18]  H. Allawi,et al.  Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High‐Grade Dysplasia in Patients With Inflammatory Bowel Disease , 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[19]  N. Mokhtar,et al.  Colonic Mucosal Transcriptomic Changes in Patients with Long-Duration Ulcerative Colitis Revealed Colitis-Associated Cancer Pathways , 2019, Journal of Crohn's & colitis.

[20]  C. Kuo,et al.  The Intestinal Stem Cell Niche: Homeostasis and Adaptations. , 2018, Trends in cell biology.

[21]  Shan Wang,et al.  BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium , 2018, Science China Life Sciences.

[22]  S. Svegliati,et al.  Sclerostin and Antisclerostin Antibody Serum Levels Predict the Presence of Axial Spondyloarthritis in Patients with Inflammatory Bowel Disease , 2018, The Journal of Rheumatology.

[23]  L. Peyrin-Biroulet,et al.  Novel therapeutic targets for inflammatory bowel disease. , 2017, Journal of autoimmunity.

[24]  S. Colucci,et al.  The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes. , 2017, Blood.

[25]  M. Neurath,et al.  Current and emerging therapeutic targets for IBD , 2017, Nature Reviews Gastroenterology & Hepatology.

[26]  M. Norkin,et al.  Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development , 2017, The EMBO journal.

[27]  Ying E Zhang,et al.  Non-Smad Signaling Pathways of the TGF-β Family. , 2017, Cold Spring Harbor perspectives in biology.

[28]  Bing Zhao,et al.  BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes , 2017, Nature Communications.

[29]  M. Ferrante,et al.  Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial , 2016, The Lancet.

[30]  D. Ahlquist,et al.  DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance , 2016, Inflammatory bowel diseases.

[31]  W. Pengfei,et al.  LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling. , 2016, Experimental cell research.

[32]  D. Brazil,et al.  BMP signalling: agony and antagony in the family. , 2015, Trends in cell biology.

[33]  R. Yantiss,et al.  ID1 Is a Functional Marker for Intestinal Stem and Progenitor Cells Required for Normal Response to Injury , 2014, Stem cell reports.

[34]  J. Li,et al.  MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling , 2014, Oncogene.

[35]  D. Ahlquist,et al.  Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease , 2013, Alimentary pharmacology & therapeutics.

[36]  S. Vukicevic,et al.  BMP signaling in rats with TNBS-induced colitis following BMP7 therapy. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[37]  C. Hong,et al.  The bone morphogenetic protein–hepcidin axis as a therapeutic target in inflammatory bowel disease , 2012, Inflammatory bowel diseases.

[38]  M. Gershon,et al.  Enteric neuronal density contributes to the severity of intestinal inflammation. , 2011, Gastroenterology.

[39]  Calvin J. Kuo,et al.  Regulation of self-renewal and differentiation by the intestinal stem cell niche , 2011, Cellular and Molecular Life Sciences.

[40]  Dawei Li,et al.  Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis , 2011, Arthritis Research & Therapy.

[41]  S. Vukicevic,et al.  BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. , 2010, Gastroenterology.

[42]  R. Kalluri,et al.  Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis* , 2010, The Journal of Biological Chemistry.

[43]  B. Cherayil Cross-talk between iron homeostasis and intestinal inflammation , 2010, Gut microbes.

[44]  M. Roth,et al.  Lack of the bone morphogenetic protein BMP6 induces massive iron overload , 2009, Nature Genetics.

[45]  Yin Xia,et al.  BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism , 2009, Nature Genetics.

[46]  H. Clevers,et al.  Stem cells, self-renewal, and differentiation in the intestinal epithelium. , 2009, Annual review of physiology.

[47]  P. Rutgeerts,et al.  Transcriptomic analysis of intestinal fibrosis‐associated gene expression in response to medical therapy in Crohn's disease , 2008, Inflammatory bowel diseases.

[48]  Suet Yi Leung,et al.  Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors , 2007, Proceedings of the National Academy of Sciences.

[49]  R. Xavier,et al.  Unravelling the pathogenesis of inflammatory bowel disease , 2007, Nature.

[50]  M. Grisham,et al.  Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[51]  R. Macleod,et al.  The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[52]  A. Bousvaros,et al.  Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation , 2006, Inflammatory bowel diseases.

[53]  E. Kouroumalis,et al.  Role of angiogenesis in inflammatory bowel disease , 2006, Inflammatory bowel diseases.

[54]  S. Baylin,et al.  Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas , 2006, Oncogene.

[55]  D. Roberts,et al.  Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[56]  K. Miyazono,et al.  BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. , 2005, Cytokine & growth factor reviews.

[57]  M. Yanagita BMP antagonists: their roles in development and involvement in pathophysiology. , 2005, Cytokine & growth factor reviews.

[58]  Xi C. He,et al.  Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior , 2005, Annals of the New York Academy of Sciences.

[59]  Y. Tabuchi,et al.  Therapeutic potential of follistatin for colonic inflammation in mice. , 2005, Gastroenterology.

[60]  Ossama Tawfik,et al.  BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling , 2004, Nature Genetics.

[61]  Hans Clevers,et al.  De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine , 2004, Science.

[62]  C. Kemp,et al.  Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. , 2004, Reproduction.

[63]  S. Vukicevic,et al.  Bone morphogenetic protein‐7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats , 2003, Journal of cellular physiology.

[64]  Nobuyuki Itoh,et al.  Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity* , 2003, Journal of Biological Chemistry.

[65]  J. Keller,et al.  Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. , 2003, Gastroenterology.

[66]  A. Economides,et al.  0163-769X/03/$20.00/0 Endocrine Reviews 24(2):218–235 Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/er.2002-0023 Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton , 2022 .

[67]  Markus Affolter,et al.  Structural basis of BMP signalling inhibition by the cystine knot protein Noggin , 2002, Nature.

[68]  A. Brivanlou,et al.  Twisted gastrulation can function as a BMP antagonist , 2001, Nature.

[69]  K. Lyons,et al.  BMP3: To Be or Not To Be a BMP , 2001, The Journal of bone and joint surgery. American volume.

[70]  R. Derynck,et al.  Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[71]  Sakae Tanaka,et al.  Negative Regulation of BMP/Smad Signaling by Tob in Osteoblasts , 2000, Cell.

[72]  R. Harland,et al.  Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[73]  Jeffrey L. Wrana,et al.  A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation , 1999, Nature.

[74]  R. Harland,et al.  The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. , 1998, Molecular cell.

[75]  K. Miyazono,et al.  Signal transduction by bone morphogenetic proteins. , 1998, Cytokine & growth factor reviews.

[76]  R. Harland,et al.  The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 , 1996, Cell.

[77]  A. Todisco,et al.  Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation. , 2017, American Journal of Physiology - Gastrointestinal and Liver Physiology.

[78]  R. Derynck,et al.  Specificity and versatility in tgf-beta signaling through Smads. , 2005, Annual review of cell and developmental biology.

[79]  J. Massagué,et al.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.

[80]  K. Sonoyama,et al.  Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[81]  C. Niehrs,et al.  Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. , 1999, Nature.