Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.

[1]  Elliot Botvinick,et al.  Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis. , 2012, Developmental cell.

[2]  G. Weinmaster,et al.  Notch ligand endocytosis: mechanistic basis of signaling activity. , 2012, Seminars in cell & developmental biology.

[3]  Xuanhua P. Xie,et al.  Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules. , 2012, Developmental biology.

[4]  K. Salaita,et al.  Visualizing mechanical tension across membrane receptors with a fluorescent sensor , 2011, Nature Methods.

[5]  G. Weinmaster,et al.  Notch ligand ubiquitylation: what is it good for? , 2011, Developmental cell.

[6]  Julian Lewis,et al.  DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock , 2011, Development.

[7]  Elliot L. Botvinick,et al.  Concentration Independent Modulation of Local Micromechanics in a Fibrin Gel , 2011, PloS one.

[8]  Sarah L. Windler,et al.  The Functions of Auxilin and Rab11 in Drosophila Suggest That the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells Is Not Recycling , 2011, PloS one.

[9]  M. von Zastrow,et al.  Role of Ubiquitination in Endocytic Trafficking of G‐Protein‐Coupled Receptors , 2011, Traffic.

[10]  Rebecca J Brady,et al.  Regulation of Hip1r by epsin controls the temporal and spatial coupling of actin filaments to clathrin-coated pits , 2010, Journal of Cell Science.

[11]  E. R. Andersson,et al.  Control of Notch-ligand endocytosis by ligand-receptor interaction , 2010, Journal of Cell Science.

[12]  David Bilder,et al.  Endocytic Internalization Routes Required for Delta/Notch Signaling , 2010, Current Biology.

[13]  G. Oster,et al.  Mechanochemical crosstalk during endocytic vesicle formation. , 2010, Current opinion in cell biology.

[14]  P. De Camilli,et al.  Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. , 2009, Developmental cell.

[15]  David G. Drubin,et al.  The Mechanochemistry of Endocytosis , 2009, PLoS biology.

[16]  G. Weinmaster,et al.  Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling , 2009, Molecular and Cellular Biology.

[17]  S. Sokol,et al.  PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis. , 2009, Developmental cell.

[18]  P. De Camilli,et al.  Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice , 2009, Proceedings of the National Academy of Sciences.

[19]  D. Loerke,et al.  Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. , 2009, Molecular biology of the cell.

[20]  K. Ayscough,et al.  Under Pressure: the Differential Requirements for Actin during Yeast and Mammalian Endocytosis , 2009, Nature Cell Biology.

[21]  H. McMahon,et al.  Mechanisms of endocytosis. , 2009, Annual review of biochemistry.

[22]  C. G. Hansen,et al.  Molecular mechanisms of clathrin-independent endocytosis , 2009, Journal of Cell Science.

[23]  M. Fortini,et al.  Notch signaling: the core pathway and its posttranslational regulation. , 2009, Developmental cell.

[24]  Raphael Kopan,et al.  The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism , 2009, Cell.

[25]  Kathryn R. Ayscough,et al.  Functions of actin in endocytosis , 2009, Cellular and Molecular Life Sciences.

[26]  I. Madshus,et al.  Epsin 1 is Involved in Recruitment of Ubiquitinated EGF Receptors into Clathrin‐Coated Pits , 2009, Traffic.

[27]  X. Zhuang,et al.  Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus , 2008, Proceedings of the National Academy of Sciences.

[28]  A. Israël,et al.  The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity , 2008, Proceedings of the National Academy of Sciences.

[29]  Henry C. Chang,et al.  The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis , 2008, BMC Developmental Biology.

[30]  J. Fischer,et al.  Auxilin is essential for Delta signaling , 2008, Development.

[31]  P. McPherson,et al.  Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly , 2008, Proceedings of the National Academy of Sciences.

[32]  Jeremy B. A. Green,et al.  PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC , 2007, Development.

[33]  E. Kremmer,et al.  Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo , 2007, The Journal of cell biology.

[34]  K. Lea,et al.  Identification of Genes That Interact With Drosophila liquid facets , 2007, Genetics.

[35]  G. Weinmaster,et al.  DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur , 2007, The Journal of cell biology.

[36]  B. Wendland,et al.  Endocytic adaptors: recruiters, coordinators and regulators. , 2006, Trends in cell biology.

[37]  Pietro De Camilli,et al.  BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. , 2006, Biochimica et biophysica acta.

[38]  T. Kirchhausen,et al.  Dynasore, a cell-permeable inhibitor of dynamin. , 2006, Developmental cell.

[39]  P. Camilli,et al.  GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission , 2006, Nature.

[40]  John P. Johnson,et al.  Clathrin-mediated Endocytosis of the Epithelial Sodium Channel , 2006, Journal of Biological Chemistry.

[41]  Henry C. Chang,et al.  Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway , 2006, The Journal of cell biology.

[42]  E. Freire,et al.  Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Harvey T. McMahon,et al.  Membrane curvature and mechanisms of dynamic cell membrane remodelling , 2005, Nature.

[44]  Bianca Habermann,et al.  Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. , 2005, Developmental cell.

[45]  G. Struhl,et al.  Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila , 2005, Development.

[46]  K. Chayama,et al.  Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis. , 2005, Journal of biochemistry.

[47]  P. De Camilli,et al.  The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[48]  F. Brodsky,et al.  Huntingtin-interacting Protein 1 (Hip1) and Hip1-related Protein (Hip1R) Bind the Conserved Sequence of Clathrin Light Chains and Thereby Influence Clathrin Assembly in Vitro and Actin Distribution in Vivo* , 2005, Journal of Biological Chemistry.

[49]  T. Schedl,et al.  Epsin potentiates Notch pathway activity in Drosophila and C. elegans , 2004, Development.

[50]  Erin Fitch,et al.  Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells , 2004, Development.

[51]  G. Struhl,et al.  Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch , 2004, Development.

[52]  W. Marshall,et al.  Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference*[boxs] , 2004, Journal of Biological Chemistry.

[53]  B. Wendland,et al.  Either Part of a Drosophila Epsin Protein, Divided after the ENTH Domain, Functions in Endocytosis of Delta in the Developing Eye , 2003, Current Biology.

[54]  O. Ohara,et al.  Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. , 2002, Developmental biology.

[55]  A. Parks,et al.  Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. , 2000, Development.

[56]  M. Grossmann,et al.  G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.

[57]  P. Simpson,et al.  Requirement for dynamin during Notch signaling in Drosophila neurogenesis. , 1997, Developmental biology.

[58]  S. Schmid,et al.  Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin , 1995, The Journal of cell biology.

[59]  Tian Xu,et al.  Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila , 1990, Cell.

[60]  M. D. De Wolf,et al.  Epsin: inducing membrane curvature. , 2007, The international journal of biochemistry & cell biology.

[61]  杉山 真一郎.  Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis , 2005 .

[62]  Cheol‐Hee Kim,et al.  Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. , 2003, Developmental cell.