Identification of an atypical variant of logopenic progressive aphasia

The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.

[1]  E. Tangalos,et al.  Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey–Osterrieth Complex Figure , 2007, Journal of clinical and experimental neuropsychology.

[2]  B. Miller,et al.  The logopenic/phonological variant of primary progressive aphasia , 2008, Neurology.

[3]  Theresa M. Harrison,et al.  Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia , 2011, Neurology.

[4]  James F. Malec,et al.  Mayo's older americans normative studies: Updated AVLT norms for ages 56 to 97 , 1992 .

[5]  L. Rapport,et al.  Psychometric properties of the visual object and space perception battery in normal older adults , 1997 .

[6]  M. Mesulam,et al.  Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia , 2010, Neurology.

[7]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[8]  Sébastien Ourselin,et al.  Progressive logopenic/phonological aphasia: Erosion of the language network , 2010, NeuroImage.

[9]  P. Rubé,et al.  L’examen Clinique en Psychologie , 1959 .

[10]  Josephine Barnes,et al.  Early-onset Alzheimer disease clinical variants , 2012, Neurology.

[11]  Maria Luisa Gorno-Tempini,et al.  Connected speech production in three variants of primary progressive aphasia. , 2010, Brain : a journal of neurology.

[12]  Alan C. Evans,et al.  A nonparametric method for automatic correction of intensity nonuniformity in MRI data , 1998, IEEE Transactions on Medical Imaging.

[13]  W. Jagust,et al.  Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia , 2008, Annals of neurology.

[14]  B. Miller,et al.  Clinical syndromes associated with posterior atrophy , 2009, Neurology.

[15]  Anders M. Dale,et al.  Reliability in multi-site structural MRI studies: Effects of gradient non-linearity correction on phantom and human data , 2006, NeuroImage.

[16]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[17]  Arthur MacNeill Horton,et al.  Wechsler Memory Scale III , 1999 .

[18]  B. Miller,et al.  Classification of primary progressive aphasia and its variants , 2011, Neurology.

[19]  B. Miller,et al.  White matter damage in primary progressive aphasias: a diffusion tensor tractography study. , 2011, Brain : a journal of neurology.

[20]  P. Osterrieth,et al.  Le test de copie d'une figure complexe; contribution à l'étude de la perception et de la mémoire. , 1944 .

[21]  M. Mesulam,et al.  Quantitative template for subtyping primary progressive aphasia. , 2009, Archives of neurology.

[22]  J. Hodges,et al.  Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation? , 2009, Journal of Neurology, Neurosurgery, and Psychiatry.

[23]  M. Mesulam,et al.  Quantitative classification of primary progressive aphasia at early and mild impairment stages. , 2012, Brain : a journal of neurology.

[24]  R. Reitan.  Validity of the Trail Making Test as an Indicator of Organic Brain Damage , 1958 .

[25]  E. Tangalos,et al.  Neuropsychological tests' norms above age 55: COWAT, BNT, MAE token, WRAT-R reading, AMNART, STROOP, TMT, and JLO , 1996 .

[26]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[27]  D. Geschwind,et al.  Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[28]  B. B. Weitner,et al.  Rate of Cognitive Change Measured by Neuropsychologic Test Performance in 3 Distinct Dementia Syndromes , 2007, Alzheimer disease and associated disorders.

[29]  B. Miller,et al.  Performance in Specific Language Tasks Correlates With Regional Volume Changes in Progressive Aphasia , 2007, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[30]  M. Weiner,et al.  Cognition and anatomy in three variants of primary progressive aphasia , 2004, Annals of neurology.

[31]  J. Morris.  The Clinical Dementia Rating (CDR) , 1993, Neurology.