Patients with adult‐onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs)

We present the clinical details and dopamine transporter SPECT scan results of 10 patients with arm tremor, including a rest component and reduced arm swing on the affected side, in whom the possibility of PD had been raised. All patients had signs of dystonia or components of their arm tremor that were compatible with dystonic tremor, and none had true akinesia with fatiguing or decrement, even after a mean follow‐up period of 5.8 years. All patients had normal dopamine transporter SPECT scans. Clinicians should be aware that primary adult‐onset dystonia can present with an asymmetric resting arm tremor, with impaired arm swing and sometimes also facial hypomimia or a jaw tremor, but without evidence of true akinesia. Given the important consequences of misdiagnosing such patients as PD, in cases with diagnostic uncertainty functional imaging should be considered. Among patients suspected of PD, dystonic tremor may be one cause of SWEDDs (Scans Without Evidence of Dopaminergic Deficit). © 2007 Movement Disorder Society

[1]  C. Marsden,et al.  Essential tremor: an overdiagnosed condition? , 2000, Journal of Neurology.

[2]  J. T. Hogan,et al.  Publications Received for Review , 2001, Phonetica.

[3]  John Seibyl,et al.  Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial. , 2004, Archives of neurology.

[4]  Claude Nahmias,et al.  Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study , 2003, Annals of neurology.

[5]  J. Obeso,et al.  Variable onset of adult inherited focal dystonia: A problem for genetic studies , 1994, Movement disorders : official journal of the Movement Disorder Society.

[6]  Stanley Fahn,et al.  Does levodopa slow or hasten the rate of progression of Parkinson’s disease? , 2005, Journal of Neurology.

[7]  Alexander Storch,et al.  Early diagnosis of Parkinson’s disease , 2006, Journal of Neurology.

[8]  Levodopa can worsen tremor associated with dystonia , 2006, Movement disorders : official journal of the Movement Disorder Society.

[9]  Nicholas W Wood,et al.  Parkin disease: a phenotypic study of a large case series. , 2003, Brain : a journal of neurology.

[10]  Andrew J Lees,et al.  Patterns of EMG–EMG coherence in limb dystonia , 2004, Movement disorders : official journal of the Movement Disorder Society.

[11]  Paul K Morrish Real‐PET and CONSORT , 2003, Annals of neurology.

[12]  C. Marsden,et al.  Orofacial dystonia and rest tremor in a patient with normal brain pathology , 1993, Movement disorders : official journal of the Movement Disorder Society.

[13]  W. Gibb,et al.  The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[14]  C D Marsden,et al.  Writers' cramp-a focal dystonia. , 1982, Brain : a journal of neurology.

[15]  M. Brin,et al.  Consensus Statement of the Movement Disorder Society on Tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[16]  G. Deuschl,et al.  Diagnostic and pathophysiological aspects of psychogenic tremors , 1998, Movement disorders : official journal of the Movement Disorder Society.