Epidemics on networks with heterogeneous population and stochastic infection rates.

In this paper we study the diffusion of an SIS-type epidemics on a network under the presence of a random environment, that enters in the definition of the infection rates of the nodes. Accordingly, we model the infection rates in the form of independent stochastic processes. To analyze the problem, we apply a mean field approximation, which allows to get a stochastic differential equations for the probability of infection in each node, and classical tools about stability, which require to find suitable Lyapunov's functions. Here, we find conditions which guarantee, respectively, extinction and stochastic persistence of the epidemics. We show that there exists two regions, given in terms of the coefficients of the model, one where the system goes to extinction almost surely, and the other where it is stochastic permanent. These two regions are, unfortunately, not adjacent, as there is a gap between them, whose extension depends on the specific level of noise. In this last region, we perform numerical analysis to suggest the true behavior of the solution.

[1]  Piet Van Mieghem,et al.  Decay towards the overall-healthy state in SIS epidemics on networks , 2013, ArXiv.

[2]  Christiane Dargatz Ludwig-Maximilian Dargatz : A Diffusion Approximation for an Epidemic Model , 2007 .

[3]  X. Mao,et al.  Environmental Brownian noise suppresses explosions in population dynamics , 2002 .

[4]  Christiane Dargatz A diffusion approximation for an epidemic model , 2006 .

[5]  Benito M. Chen-Charpentier,et al.  Random coefficient differential equation models for bacterial growth , 2009, Math. Comput. Model..

[6]  Francesco De Pellegrini,et al.  Epidemic Outbreaks in Networks with Equitable or Almost-Equitable Partitions , 2014, SIAM J. Appl. Math..

[7]  P. V. Mieghem,et al.  Accuracy criterion for the mean-field approximation in susceptible-infected-susceptible epidemics on networks. , 2015 .

[8]  Xuerong Mao,et al.  Population dynamical behavior of Lotka-Volterra system under regime switching , 2009, J. Comput. Appl. Math..

[9]  Xuerong Mao,et al.  Stochastic differential equations and their applications , 1997 .

[10]  Pasquale Vetro,et al.  Stability of a stochastic SIR system , 2005 .

[11]  Philip K. Pollett,et al.  Diffusion approximations for ecological models , 2001 .

[12]  Ingemar Nåsell,et al.  Stochastic models of some endemic infections. , 2002, Mathematical biosciences.

[13]  P. Van Mieghem,et al.  Virus Spread in Networks , 2009, IEEE/ACM Transactions on Networking.

[14]  Tom Britton,et al.  Stochastic epidemic models: a survey. , 2009, Mathematical biosciences.

[15]  L. Allen An Introduction to Stochastic Epidemic Models , 2008 .

[16]  I. Kiss,et al.  Exact epidemic models on graphs using graph-automorphism driven lumping , 2010, Journal of mathematical biology.

[17]  Moez Draief,et al.  Epidemics and Rumours in Complex Networks , 2010 .

[18]  P Van Mieghem,et al.  Accuracy criterion for the mean-field approximation in susceptible-infected-susceptible epidemics on networks. , 2015, Physical review. E, Statistical, nonlinear, and soft matter physics.

[19]  Desmond J. Higham,et al.  An Algorithmic Introduction to Numerical Simulation of Stochastic Differential Equations , 2001, SIAM Rev..

[20]  Xuerong Mao,et al.  Stochastic population dynamics under regime switching II , 2007 .

[21]  J. Yorke,et al.  A Deterministic Model for Gonorrhea in a Nonhomogeneous Population , 1976 .

[22]  Simon M. J. Lyons Introduction to stochastic differential equations , 2011 .

[23]  R. Khasminskii Stochastic Stability of Differential Equations , 1980 .

[24]  F. Vázquez,et al.  Slow epidemic extinction in populations with heterogeneous infection rates. , 2013, Physical review. E, Statistical, nonlinear, and soft matter physics.

[25]  Eric Renshaw,et al.  Asymptotic behaviour of the stochastic Lotka-Volterra model , 2003 .

[26]  Liangjian Hu,et al.  A Stochastic Differential Equation SIS Epidemic Model , 2011, SIAM J. Appl. Math..

[27]  P Van Mieghem,et al.  Nodal infection in Markovian susceptible-infected-susceptible and susceptible-infected-removed epidemics on networks are non-negatively correlated. , 2014, Physical review. E, Statistical, nonlinear, and soft matter physics.

[28]  Alessandro Vespignani,et al.  Inferring the Structure of Social Contacts from Demographic Data in the Analysis of Infectious Diseases Spread , 2012, PLoS Comput. Biol..

[29]  Christian Kuehn,et al.  Heterogeneous population dynamics and scaling laws near epidemic outbreaks. , 2014, Mathematical biosciences and engineering : MBE.

[30]  T. Kurtz Limit theorems for sequences of jump Markov processes approximating ordinary differential processes , 1971, Journal of Applied Probability.

[31]  Donald F. Towsley,et al.  The effect of network topology on the spread of epidemics , 2005, Proceedings IEEE 24th Annual Joint Conference of the IEEE Computer and Communications Societies..

[32]  K. Sato,et al.  Evolution of predator–prey systems described by a Lotka–Volterra equation under random environment , 2006 .

[33]  Xuerong Mao,et al.  Population dynamical behavior of non-autonomous Lotka-Volterra competitive system with random perturbation , 2009 .

[34]  J. B. Walsh,et al.  An introduction to stochastic partial differential equations , 1986 .

[35]  Piet Van Mieghem,et al.  Epidemic processes in complex networks , 2014, ArXiv.

[36]  Ingemar Nåsell,et al.  The quasi-stationary distribution of the closed endemic sis model , 1996, Advances in Applied Probability.

[37]  I. Nåsell The quasi-stationary distribution of the closed endemic sis model , 1996, Advances in Applied Probability.

[38]  R. Anderson,et al.  Sexually transmitted diseases and sexual behavior: insights from mathematical models. , 1996, The Journal of infectious diseases.

[39]  Piet Van Mieghem,et al.  The viral conductance of a network , 2012, Comput. Commun..

[40]  Yongsheng Ding,et al.  Asymptotic behavior and stability of a stochastic model for AIDS transmission , 2008, Appl. Math. Comput..

[41]  Piet Van Mieghem,et al.  Exact Markovian SIR and SIS epidemics on networks and an upper bound for the epidemic threshold , 2014, 1402.1731.

[42]  D. Valenti,et al.  Noise in ecosystems: a short review. , 2004, Mathematical biosciences and engineering : MBE.

[43]  D. Williams STOCHASTIC DIFFERENTIAL EQUATIONS: THEORY AND APPLICATIONS , 1976 .

[44]  Stefania Ottaviano,et al.  Epidemic outbreaks in two-scale community networks. , 2014, Physical review. E, Statistical, nonlinear, and soft matter physics.

[45]  Bo Qu,et al.  SIS Epidemic Spreading with Heterogeneous Infection Rates , 2015, IEEE Transactions on Network Science and Engineering.

[46]  David G. Rand,et al.  the high Himalayas and Antarctica Phylogeography of microbial phototrophs in the dry valleys of Supplementary data tml , 2010 .

[47]  M. Keeling The implications of network structure for epidemic dynamics. , 2005, Theoretical population biology.

[48]  Mark E. J. Newman,et al.  The Structure and Function of Complex Networks , 2003, SIAM Rev..

[49]  E. Seneta,et al.  On quasi-stationary distributions in absorbing continuous-time finite Markov chains , 1967, Journal of Applied Probability.