Design of Ti64/Ta Hybrid Materials by Powder Metallurgy Mimicking Bone Structure

This work reports on the fabrication of a novel two-layer material composed of a porous tantalum core and a dense Ti6Al4V (Ti64) shell by powder metallurgy. The porous core was obtained by mixing Ta particles and salt space-holders to create large pores, the green compact was obtained by pressing. The sintering behavior of the two-layer sample was studied by dilatometry. The interface bonding between the Ti64 and Ta layers was analyzed by SEM, and the pore characteristics were analyzed by computed microtomography. Images showed that two distinct layers were obtained with a bonding achieved by the solid-state diffusion of Ta particles into Ti64 during sintering. The formation of β-Ti and α′ martensitic phases confirmed the diffusion of Ta. The pore size distribution was in the size range of 80 to 500 µm, and a permeability value of 6 × 10−10 m2 was close to the trabecular bones one. The mechanical properties of the component were dominated mainly by the porous layer, and Young’s modulus of 16 GPa was in the range of bones. Additionally, the density of this material (6 g/cm3) was much lower than the one of pure Ta, which helps to reduce the weight for the desired applications. These results indicate that structurally hybridized materials, also known as composites, with specific property profiles can improve the response to osseointegration for bone implant applications.

[1]  Xufeng Niu,et al.  Biomechanics and mechanobiology of the bone matrix , 2022, Bone Research.

[2]  H. Vergara-Hernández,et al.  Ti64/20Ag Porous Composites Fabricated by Powder Metallurgy for Biomedical Applications , 2022, Materials.

[3]  L. Pires,et al.  An analysis of three XCT-based methods to determine the intrinsic permeability of soil aggregates , 2022, Journal of Hydrology.

[4]  Shih-Hao Chen,et al.  In Vitro and In Vivo Comparison of Bone Growth Characteristics in Additive-Manufactured Porous Titanium, Nonporous Titanium, and Porous Tantalum Interbody Cages , 2022, Materials.

[5]  F. Tarlochan,et al.  Design of Titanium Alloy Femoral Stem Cellular Structure for Stress Shielding and Stem Stability: Computational Analysis , 2022, Applied Sciences.

[6]  Deqiao Xie,et al.  Analysis of Mechanical Properties and Permeability of Trabecular-Like Porous Scaffold by Additive Manufacturing , 2021, Frontiers in Bioengineering and Biotechnology.

[7]  M. S. Hefzy,et al.  Biomechanics of Additively Manufactured Metallic Scaffolds—A Review , 2021, Materials.

[8]  Shupei Zhang,et al.  Porous tantalum scaffolds: Fabrication, structure, properties, and orthopedic applications , 2021, Materials & Design.

[9]  H. Vergara-Hernández,et al.  Design of architectured Ti6Al4V-based materials for biomedical applications fabricated via powder metallurgy , 2021, Materials Today Communications.

[10]  M. Punset,et al.  Powder metallurgy with space holder for porous titanium implants: A review , 2021 .

[11]  Gan Huang,et al.  The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering , 2021, Materials.

[12]  E. Fiume,et al.  Digital light processing stereolithography of hydroxyapatite scaffolds with bone‐like architecture, permeability, and mechanical properties , 2021, Journal of the American Ceramic Society.

[13]  Huawei Qu Additive manufacturing for bone tissue engineering scaffolds , 2020 .

[14]  J. Liao,et al.  Biomimetic Design for a Dual Concentric Porous Titanium Scaffold with Appropriate Compressive Strength and Cells Affinity , 2020, Materials.

[15]  P. Fernandes,et al.  On the permeability of TPMS scaffolds. , 2020, Journal of the mechanical behavior of biomedical materials.

[16]  D. Kent,et al.  Additive manufacturing of low-cost porous titanium-based composites for biomedical applications: Advantages, challenges and opinion for future development , 2020 .

[17]  David Z. Zhang,et al.  Additively Manufactured Continuous Cell-Size Gradient Porous Scaffolds: Pore Characteristics, Mechanical Properties and Biological Responses In Vitro , 2020, Materials.

[18]  Y. Torres,et al.  Influence of the Compaction Pressure and Sintering Temperature on the Mechanical Properties of Porous Titanium for Biomedical Applications , 2019 .

[19]  D Barba,et al.  Synthetic Bone: Design by Additive Manufacturing. , 2019, Acta biomaterialia.

[20]  Chenyu Wang,et al.  Porous Tantalum and Titanium in Orthopedics: A Review. , 2019, ACS biomaterials science & engineering.

[21]  H. Montazerian,et al.  Permeability and mechanical properties of gradient porous PDMS scaffolds fabricated by 3D-printed sacrificial templates designed with minimal surfaces. , 2019, Acta biomaterialia.

[22]  Sonia Mariel Vrech,et al.  Advances in additive manufacturing for bone tissue engineering scaffolds. , 2019, Materials science & engineering. C, Materials for biological applications.

[23]  Roger C. Reed,et al.  Design of metallic bone by additive manufacturing , 2019, Scripta Materialia.

[24]  Xionggang Lu,et al.  Porous tantalum scaffold fabricated by gel casting based on 3D printing and electrolysis , 2019, Materials Letters.

[25]  Ankit Yadav,et al.  Modeling and Characterization of Porous Tantalum Scaffolds , 2019, Transactions of the Indian Institute of Metals.

[26]  A. A. Zadpoor,et al.  Topological design, permeability and mechanical behavior of additively manufactured functionally graded porous metallic biomaterials. , 2019, Acta biomaterialia.

[27]  H. Vergara-Hernández,et al.  Sintering study of Ti6Al4V powders with different particle sizes and their mechanical properties , 2018, International Journal of Minerals, Metallurgy, and Materials.

[28]  D. Bouvard,et al.  Analysis of Compression and Permeability Behavior of Porous Ti6Al4V by Computed Microtomography , 2018, Metals and Materials International.

[29]  T. Ginta,et al.  Effect of Unit Cell Type and Pore Size on Porosity and Mechanical Behavior of Additively Manufactured Ti6Al4V Scaffolds , 2018, Materials.

[30]  Amit Bandyopadhyay,et al.  Calcium phosphate coated 3D printed porous titanium with nanoscale surface modification for orthopedic and dental applications. , 2018, Materials & design.

[31]  Scott J Hollister,et al.  Design and Structure–Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering , 2018, Advanced healthcare materials.

[32]  D. Bouvard,et al.  Processing and properties of highly porous Ti6Al4V mimicking human bones , 2018 .

[33]  G. Yuan,et al.  Precise fabrication of open porous Mg scaffolds using NaCl templates: Relationship between space holder particles, pore characteristics and mechanical behavior , 2018 .

[34]  M. Leeflang,et al.  Diametral compression behavior of biomedical titanium scaffolds with open, interconnected pores prepared with the space holder method. , 2017, Journal of the mechanical behavior of biomedical materials.

[35]  Wei Xu,et al.  Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review. , 2016, Biomaterials.

[36]  Shahab Ahmadi,et al.  A novel method for production of foamy core@compact shell Ti6Al4V bone-like composite , 2016 .

[37]  C. Aparicio,et al.  Development of tantalum scaffold for orthopedic applications produced by space-holder method , 2015 .

[38]  Jan Wieding,et al.  Influence of Different Three-Dimensional Open Porous Titanium Scaffold Designs on Human Osteoblasts Behavior in Static and Dynamic Cell Investigations , 2015, Materials.

[39]  Duu-Jong Lee,et al.  Space-holder effect on designing pore structure and determining mechanical properties in porous titanium , 2014 .

[40]  Jie Zhou,et al.  Fabrication of Metallic Biomedical Scaffolds with the Space Holder Method: A Review , 2014, Materials.

[41]  D. Gallo,et al.  A Survey of Methods for the Evaluation of Tissue Engineering Scaffold Permeability , 2013, Annals of Biomedical Engineering.

[42]  Yadir Torres,et al.  Processing and characterization of porous titanium for implants by using NaCl as space holder , 2012 .

[43]  P R Fernandes,et al.  Permeability analysis of scaffolds for bone tissue engineering. , 2012, Journal of biomechanics.

[44]  Wojciech Swieszkowski,et al.  Highly porous titanium scaffolds for orthopaedic applications. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[45]  Aldo R Boccaccini,et al.  Permeability evaluation of 45S5 Bioglass-based scaffolds for bone tissue engineering. , 2009, Journal of biomechanics.

[46]  H. Hosoda,et al.  Shape memory behavior of Ti–Ta and its potential as a high-temperature shape memory alloy , 2009 .

[47]  Amit Bandyopadhyay,et al.  Engineered porous metals for implants , 2008 .

[48]  B Vamsi Krishna,et al.  Processing and biocompatibility evaluation of laser processed porous titanium. , 2007, Acta biomaterialia.

[49]  M. Niinomi,et al.  Effects of Ta content on Young’s modulus and tensile properties of binary Ti–Ta alloys for biomedical applications , 2004 .

[50]  Mitsuo Niinomi,et al.  Recent metallic materials for biomedical applications , 2002 .

[51]  C. Ohtsuki,et al.  Mechanism of bonelike apatite formation on bioactive tantalum metal in a simulated body fluid. , 2002, Biomaterials.

[52]  T. M. Keaveny,et al.  Dependence of Intertrabecular Permeability on Flow Direction and Anatomic Site , 1999, Annals of Biomedical Engineering.

[53]  Z. Guo,et al.  Theoretical study of the effects of alloying elements on the strength and modulus of β-type bio-titanium alloys , 1999 .

[54]  D. Adamović,et al.  Review of Existing Biomaterials—Method of Material Selection for Specific Applications in Orthopedics , 2018 .

[55]  M. Shukla,et al.  Lattice Modeling and CFD Simulation for Prediction of Permeability in Porous Scaffolds , 2018 .

[56]  E. Ferrié,et al.  Characterization of the structure and permeability of titanium foams for spinal fusion devices. , 2009, Acta biomaterialia.

[57]  D. Dempster,et al.  New Concepts in Bone Remodeling , 2006 .

[58]  Jochem Nagels,et al.  Stress shielding and bone resorption in shoulder arthroplasty. , 2003, Journal of shoulder and elbow surgery.

[59]  L D Zardiackas,et al.  Structure, metallurgy, and mechanical properties of a porous tantalum foam. , 2001, Journal of biomedical materials research.

[60]  H. Aro,et al.  Pore diameter of more than 100 μm is not requisite for bone ingrowth in rabbits , 2001 .

[61]  R. Huiskes,et al.  The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. , 1992, Clinical orthopaedics and related research.

[62]  F. Melsen,et al.  Trabecular bone remodeling and balance in primary hyperparathyroidism. , 1986, Bone.