Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction

[1]  C. R. Ethier,et al.  Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. , 2014, Experimental eye research.

[2]  C. R. Ethier,et al.  Altered mechanobiology of Schlemm’s canal endothelial cells in glaucoma , 2014, Proceedings of the National Academy of Sciences.

[3]  S. Jorgensen,et al.  Anatomic changes in Schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures. , 2014, Investigative ophthalmology & visual science.

[4]  D. Epstein,et al.  Emerging trabecular outflow drugs. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[5]  A. Clark,et al.  The role of TGF-β2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[6]  Y. H. ChangJason,et al.  Multi-Scale Analysis of Segmental Outflow Patterns in Human Trabecular Meshwork with Changing Intraocular Pressure , 2014 .

[7]  Pedro Gonzalez,et al.  Circumferential tensile stiffness of glaucomatous trabecular meshwork. , 2014, Investigative ophthalmology & visual science.

[8]  David A Weitz,et al.  The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. , 2013, Biophysical journal.

[9]  H. Gong,et al.  The effect of the endothelial cell cortex on atomic force microscopy measurements. , 2013, Biophysical journal.

[10]  W. Stamer,et al.  Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow. , 2013, Investigative ophthalmology & visual science.

[11]  T. Acott,et al.  The Juxtacanalicular Region of Ocular Trabecular Meshwork: A Tissue with a Unique Extracellular Matrix and Specialized Function. , 2013, Journal of ocular biology.

[12]  M. Gardel,et al.  Endothelial barrier disruption and recovery is controlled by substrate stiffness. , 2013, Microvascular research.

[13]  S. Swaminathan,et al.  Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow. , 2013, Investigative ophthalmology & visual science.

[14]  A. Harris,et al.  The role of transforming growth factor β in glaucoma and the therapeutic implications , 2013, British Journal of Ophthalmology.

[15]  Christopher J Murphy,et al.  Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ. , 2013, Investigative ophthalmology & visual science.

[16]  C. R. Ethier,et al.  Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. , 2012, Investigative ophthalmology & visual science.

[17]  J. Fredberg,et al.  Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow , 2012, Journal of The Royal Society Interface.

[18]  A. Bosserhoff,et al.  Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. , 2012, The American journal of pathology.

[19]  P. Kaufman,et al.  Comparisons of actin filament disruptors and Rho kinase inhibitors as potential antiglaucoma medications , 2012, Expert review of ophthalmology.

[20]  E. Spörl,et al.  Reproducibility Of New Different Pachymetric Measuring Methods , 2012 .

[21]  Ted S Acott,et al.  Current understanding of conventional outflow dysfunction in glaucoma , 2012, Current opinion in ophthalmology.

[22]  W. Stamer,et al.  Protein markers and differentiation in culture for Schlemm's canal endothelial cells. , 2012, Experimental eye research.

[23]  P. Russell,et al.  Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells. , 2012, Investigative ophthalmology & visual science.

[24]  C. R. Ethier,et al.  eNOS, a pressure-dependent regulator of intraocular pressure. , 2011, Investigative ophthalmology & visual science.

[25]  G. Novack,et al.  Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. , 2011, American journal of ophthalmology.

[26]  E. Ongini,et al.  Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models. , 2011, Experimental eye research.

[27]  M. Robinson,et al.  Novel ocular antihypertensive compounds in clinical trials , 2011, Clinical ophthalmology.

[28]  W. Stamer,et al.  The role of the prostaglandin EP4 receptor in the regulation of human outflow facility. , 2011, Investigative ophthalmology & visual science.

[29]  P. Russell,et al.  Elastic modulus determination of normal and glaucomatous human trabecular meshwork. , 2011, Investigative ophthalmology & visual science.

[30]  D. Overby The Mechanobiology of Aqueous Humor Transport across Schlemm's Canal Endothelium , 2011 .

[31]  P. Russell,et al.  The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents. , 2011, Biomaterials.

[32]  D. Epstein,et al.  Rho GTPase‐mediated cytoskeletal organization in Schlemm's canal cells play a critical role in the regulation of aqueous humor outflow facility , 2011, Journal of cellular biochemistry.

[33]  A. Read,et al.  Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia , 2011, Molecular vision.

[34]  W. Stamer,et al.  Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. , 2010, Investigative ophthalmology & visual science.

[35]  C. R. Ethier,et al.  A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. , 2010, Investigative ophthalmology & visual science.

[36]  L. Cancio,et al.  Half empty or half full? , 2010, Critical care medicine.

[37]  I. Pang,et al.  Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes. , 2010, Investigative ophthalmology & visual science.

[38]  C. Ross Ethier,et al.  Young’s modulus of elasticity of Schlemm’s canal endothelial cells , 2010, Biomechanics and modeling in mechanobiology.

[39]  J. Ando,et al.  Vascular mechanobiology: endothelial cell responses to fluid shear stress. , 2009, Circulation journal : official journal of the Japanese Circulation Society.

[40]  S. Nilsson,et al.  Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow. , 2009, Investigative ophthalmology & visual science.

[41]  P. Arratia,et al.  Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin. , 2009, Biophysical journal.

[42]  W. Stamer,et al.  The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. , 2009, Experimental eye research.

[43]  P. Kaufman,et al.  The role of the actomyosin system in regulating trabecular fluid outflow. , 2009, Experimental eye research.

[44]  T. Holak,et al.  Lifeact: a versatile marker to visualize F-actin , 2008, Nature Methods.

[45]  Kheya Sengupta,et al.  Fibroblast adaptation and stiffness matching to soft elastic substrates. , 2007, Biophysical journal.

[46]  R. Geha,et al.  Transcellular diapedesis is initiated by invasive podosomes. , 2007, Immunity.

[47]  J. Hoying,et al.  Schlemm's Canal Endothelia, Lymphatic, or Blood Vasculature? , 2007, Journal of glaucoma.

[48]  T. Freddo,et al.  New Morphological Findings in Primary Open-Angle Glaucoma , 2007 .

[49]  C. R. Ethier,et al.  Actin structure in the outflow tract of normal and glaucomatous eyes. , 2006, Experimental eye research.

[50]  C. R. Ethier,et al.  Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. , 2006, Investigative ophthalmology & visual science.

[51]  Mark Johnson,et al.  'What controls aqueous humour outflow resistance?'. , 2006, Experimental eye research.

[52]  Donald E Ingber,et al.  Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. , 2005, Acta biomaterialia.

[53]  D. Epstein,et al.  Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. , 2005, Molecular vision.

[54]  R. Stone,et al.  Differential P1-purinergic modulation of human Schlemm's canal inner-wall cells. , 2005, American journal of physiology. Cell physiology.

[55]  J. Caprioli,et al.  Prediction of visual field progression in glaucoma. , 2004, Investigative ophthalmology & visual science.

[56]  H. Haga,et al.  Contribution of cellular contractility to spatial and temporal variations in cellular stiffness. , 2004, Experimental cell research.

[57]  Priyatham S. Mettu,et al.  Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. , 2004, Investigative ophthalmology & visual science.

[58]  J. Alvarado,et al.  Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features. , 2004, American journal of physiology. Cell physiology.

[59]  Linhong Deng,et al.  Mechanical strain increases cell stiffness through cytoskeletal filament reorganization. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[60]  Anders Heijl,et al.  Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. , 2003, Archives of ophthalmology.

[61]  Thomas F Freddo,et al.  The mechanism of increasing outflow facility during washout in the bovine eye. , 2002, Investigative ophthalmology & visual science.

[62]  William E Kraus,et al.  Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. , 2002, American journal of physiology. Cell physiology.

[63]  M. C. Leske,et al.  Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. , 2002, Archives of ophthalmology.

[64]  Miroslav Zivkovic,et al.  A finite element model of cell deformation during magnetic bead twisting. , 2002, Journal of applied physiology.

[65]  C. R. Ethier,et al.  The pore density in the inner wall endothelium of Schlemm's canal of glaucomatous eyes. , 2002, Investigative ophthalmology & visual science.

[66]  T. Shearer,et al.  Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells. , 2002, Investigative ophthalmology & visual science.

[67]  D. Epstein,et al.  Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. , 2002, Molecular vision.

[68]  Ben Fabry,et al.  Traction fields, moments, and strain energy that cells exert on their surroundings. , 2002, American journal of physiology. Cell physiology.

[69]  C. Michel,et al.  Openings in frog microvascular endothelium at different rates of increase in pressure and at different temperatures , 2002, The Journal of physiology.

[70]  D. Navajas,et al.  Scaling the microrheology of living cells. , 2001, Physical review letters.

[71]  M. Swartz,et al.  The physiology of the lymphatic system. , 2001, Advanced drug delivery reviews.

[72]  J J Fredberg,et al.  Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells. , 2001, Journal of applied physiology.

[73]  D. Epstein,et al.  Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. , 2001, Investigative ophthalmology & visual science.

[74]  P. Kaufman,et al.  H-7 effects on the structure and fluid conductance of monkey trabecular meshwork. , 2000, Archives of ophthalmology.

[75]  P. Kaufman,et al.  Cytoskeletal involvement in the regulation of aqueous humor outflow. , 2000, Investigative ophthalmology & visual science.

[76]  D. Epstein,et al.  Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. , 1999, American journal of physiology. Cell physiology.

[77]  P. Kaufman,et al.  Latrunculin-A increases outflow facility in the monkey. , 1999, Investigative ophthalmology & visual science.

[78]  C. Michel,et al.  Openings Through Endothelial Cells Associated with Increased Microvascular Permeability , 1999, Microcirculation.

[79]  B. Yawn,et al.  The probability of blindness from open-angle glaucoma. , 1998, Ophthalmology.

[80]  C. R. Ethier,et al.  Two pore types in the inner-wall endothelium of Schlemm's canal. , 1998, Investigative ophthalmology & visual science.

[81]  D. Epstein,et al.  Isolation, culture, and characterization of endothelial cells from Schlemm's canal. , 1998, Investigative ophthalmology & visual science.

[82]  C. Michel,et al.  Transcellular openings through frog microvascular endothelium , 1997, Experimental physiology.

[83]  A. Bank,et al.  Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus. , 1996, Circulation.

[84]  J. Streilein Ocular immune privilege and the Faustian dilemma. The Proctor lecture. , 1996, Investigative ophthalmology & visual science.

[85]  D. Johnson Human trabecular meshwork cell survival is dependent on perfusion rate. , 1996, Investigative ophthalmology & visual science.

[86]  C. Michel,et al.  Openings in frog microvascular endothelium induced by high intravascular pressures. , 1996, The Journal of physiology.

[87]  H. Gong,et al.  Morphology of the aqueous outflow pathway , 1996, Microscopy research and technique.

[88]  C. Michel,et al.  Transcellular gaps in microvascular walls of frog and rat when permeability is increased by perfusion with the ionophore A23187. , 1995, The Journal of physiology.

[89]  R. Tripathi,et al.  Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2 , 1994 .

[90]  D E Ingber,et al.  Mechanotransduction across the cell surface and through the cytoskeleton. , 1993, Science.

[91]  C G Murphy,et al.  Juxtacanalicular tissue in pigmentary and primary open angle glaucoma. The hydrodynamic role of pigment and other constituents. , 1992, Archives of ophthalmology.

[92]  C. R. Ethier,et al.  Modulation of outflow resistance by the pores of the inner wall endothelium. , 1992, Investigative ophthalmology & visual science.

[93]  C. R. Ethier,et al.  The relationship between pore density and outflow facility in human eyes. , 1992, Investigative ophthalmology & visual science.

[94]  R M Nerem,et al.  The application of a homogeneous half-space model in the analysis of endothelial cell micropipette measurements. , 1988, Journal of biomechanical engineering.

[95]  A. J. Yun,et al.  Juxtacanalicular tissue in primary open angle glaucoma and in nonglaucomatous normals. , 1986, Archives of ophthalmology.

[96]  J. Rohen,et al.  Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes. , 1986, Experimental eye research.

[97]  J. Alvarado,et al.  Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals. , 1984, Ophthalmology.

[98]  J. Polansky,et al.  Age-related changes in trabecular meshwork cellularity. , 1981, Investigative ophthalmology & visual science.

[99]  J. Rohen,et al.  The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. , 1981, Investigative ophthalmology & visual science.

[100]  J. Rohen,et al.  Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. , 1981, Investigative ophthalmology & visual science.

[101]  E. Raviola,et al.  Paracellular route of aqueous outflow in the trabecular meshwork and canal of Schlemm. A freeze-fracture study of the endothelial junctions in the sclerocorneal angel of the macaque monkey eye. , 1981, Investigative ophthalmology & visual science.

[102]  I. Grierson,et al.  Associations between the cells of the walls of Schlemm's canal , 1978, Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie.

[103]  D E Gaasterland,et al.  The rate of reflux fluid movement into the eye from Schlemm's canal during hypotony in the rhesus monkey. , 1978, Investigative ophthalmology & visual science.

[104]  M. Johnstone,et al.  Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes. , 1973, American journal of ophthalmology.

[105]  B. Svedbergh,et al.  SCANNING ELECTRON MICROSCOPIC STUDIES OF THE TRABECULAR MESHWORK AND THE CANAL OF SCHLEMM ‐ AN ATTEMPT TO LOCALIZE THE MAIN RESISTANCE TO OUTFLOW OF AQUEOUS HUMOR IN MAN , 1972 .

[106]  G. K. Smelser,et al.  Aqueous humor pathways through the trabecular meshwork and into Schlemm's canal in the cynomolgus monkey (Macaca irus). An electron microscopic study. , 1972, American journal of ophthalmology.

[107]  Å. Holmberg The Fine Structure of the Inner Wall of Schlemm's Canal , 1959 .

[108]  Grant Wm,et al.  Clinical measurements of aqueous outflow. , 1951 .

[109]  Dr. Krükow,et al.  Studien über den Flüssigkeitswechsel im Auge , 1873, Albrecht von Graefes Archiv für Ophthalmologie.

[110]  Proctor Lecture Ocular Immune Privilege and the Faustian Dilemma , 2017 .

[111]  D. Overby,et al.  Multi-scale analysis of segmental outflow patterns in human trabecular meshwork with changing intraocular pressure. , 2014, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[112]  D. Epstein,et al.  Rho GTPase/Rho Kinase Inhibition as a Novel Target for the Treatment of Glaucoma , 2012, BioDrugs.

[113]  P. Russell,et al.  Elastic modulus determination of normal and glaucomatous human trabecular meshwork. , 2012, Investigative ophthalmology & visual science.

[114]  R. Pedrigi,et al.  A model of giant vacuole dynamics in human Schlemm's canal endothelial cells. , 2011, Experimental eye research.

[115]  T. Wecker,et al.  Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells. , 2008, Investigative ophthalmology & visual science.

[116]  V. Arshavsky,et al.  Progress in Retinal and Eye Research , 2008 .

[117]  J. Crocker,et al.  Multiple-particle tracking and two-point microrheology in cells. , 2007, Methods in cell biology.

[118]  I. Pang,et al.  TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure. , 2006, Investigative ophthalmology & visual science.

[119]  P. Kaufman,et al.  Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeys. , 2004, Transactions of the American Ophthalmological Society.

[120]  C. R. Ethier,et al.  Effects of TGF-beta2 in perfused human eyes. , 2004, Investigative ophthalmology & visual science.

[121]  R. Hochmuth,et al.  Micropipette aspiration of living cells. , 2000, Journal of biomechanics.

[122]  Mark P. Johnson,et al.  Mechanisms and routes of aqueous humor drainage , 2000 .

[123]  D. Epstein,et al.  Acto-myosin drug effects and aqueous outflow function. , 1999, Investigative ophthalmology & visual science.

[124]  C. R. Ethier,et al.  Schlemm's canal and primary open angle glaucoma: correlation between Schlemm's canal dimensions and outflow facility. , 1996, Experimental eye research.

[125]  D. Epstein,et al.  Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. , 1991, Investigative ophthalmology & visual science.

[126]  W M Lai,et al.  Fluid transport and mechanical properties of articular cartilage: a review. , 1984, Journal of biomechanics.

[127]  N. Simionescu,et al.  Structural aspects of the permeability of the microvascular endothelium. , 1979, Acta physiologica Scandinavica. Supplementum.

[128]  R. Tripathi,et al.  The functional morphology of the outflow systems of ocular and cerebrospinal fluids. , 1977, Experimental eye research.

[129]  W. M. Grant,et al.  Clinical measurements of aqueous outflow. , 1951, A.M.A. archives of ophthalmology.