Stereoselective Synthesis of Chiral (2-Furyl)Amino-Methanephosphonic and Aminophosphonous Acids
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Stereoselective synthesis of (2-furyl)-N-methylbenzylaminophosphonate was performed by the addition of dibenzyl phosphate to N-furfurylidene (R)-α-methylbenzylamine[1]. Resulting diastereoisomeric esters were separated and characterised. As both products were oily liquids, the X-ray study could not have been made. So, we determined the absolute configuration on the base of Cram rules and confirmed it according to Riguera's[2] method.
[1] B. Walker,et al. A highly convenient route to optically pure α-aminophosphonic acids , 1995 .
[2] J. Seco,et al. Determination of the Absolute Stereochemistry of Chiral Amines by 1H NMR of Arylmethoxyacetic Acid Amides: The Conformational Model , 1995 .
[3] C. Yuan,et al. STUDIES ON ORGANOPHOSPHORUS COMPOUNDS XL VIII STRUCTURAL EFFECT ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO CHIRAL ALDIMINE DERIVATIVES , 1991 .