GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice
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A. Feuchtinger | D. Drucker | M. Tschöp | S. Herzig | R. DiMarchi | T. Müller | B. Staels | D. Perez-Tilve | G. Colldén | M. A. Sánchez-Garrido | Natalie Krahmer | H. Lickert | C. Clemmensen | S. Hofmann | B. Finan | Jonathan E. Campbell | K. Stemmer | Perla Cota | C. García-Cáceres | Bin Yang | C. Quarta | M. Capozzi | E. Baugé | N. Hennuyer | Qian Zhang | S. Prakash | A. Harger | B. Dubois | D. Liśkiewicz | A. Liśkiewicz | Aaron Novikoff | F. Lalloyer | M. Bakhti | Aimée Bastidas-Ponce | Gerald Grandl | E. Baugé | P. Knerr | Jonathan D Douros | Felix Klingelhuber | Konxhe Kulaj | Gandhari Maity | Jonathan D. Douros
[1] B. Staels,et al. PPAR control of metabolism and cardiovascular functions , 2021, Nature Reviews Cardiology.
[2] A. Vidal-Puig,et al. GTTs and ITTs in mice: simple tests, complex answers , 2021, Nature Metabolism.
[3] F. Rigo,et al. Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide. , 2020, Journal of medicinal chemistry.
[4] J. Ahnfelt-Rønne,et al. Semaglutide lowers body weight in rodents via distributed neural pathways. , 2020, JCI insight.
[5] Fabian J Theis,et al. Targeted pharmacological therapy restores β-cell function for diabetes remission , 2020, Nature Metabolism.
[6] H. Lebovitz. Thiazolidinediones: the Forgotten Diabetes Medications , 2019, Current Diabetes Reports.
[7] M. Blüher,et al. NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression , 2019, Molecular metabolism.
[8] P. Balakumar,et al. A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia , 2019, Current molecular pharmacology.
[9] D. Belsham,et al. Bisphenol A induces Pomc gene expression through neuroinflammatory and PPARγ nuclear receptor-mediated mechanisms in POMC-expressing hypothalamic neuronal models , 2019, Molecular and Cellular Endocrinology.
[10] C. Ämmälä,et al. Targeted delivery of antisense oligonucleotides to pancreatic β-cells , 2018, Science Advances.
[11] Knut Conradsen,et al. Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment , 2018, Scientific Reports.
[12] Heng Zhang,et al. Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake , 2018, Neuropeptides.
[13] N. Lambert,et al. Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells , 2018, The Journal of Biological Chemistry.
[14] Casper Bo Jensen,et al. Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization , 2018, Endocrinology.
[15] M. Delgado-Rodríguez,et al. Systematic review and meta-analysis. , 2017, Medicina intensiva.
[16] T. Strom,et al. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. , 2017, Cell metabolism.
[17] J. Eeckhoute,et al. Distinct but complementary contributions of PPAR isotypes to energy homeostasis. , 2017, The Journal of clinical investigation.
[18] H. Fuchs,et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease , 2016, Cell.
[19] Oliver M. Bernhardt,et al. Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues* , 2015, Molecular & Cellular Proteomics.
[20] M. Mulero,et al. Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET) , 2013, PloS one.
[21] Bin Yang,et al. Targeted estrogen delivery reverses the metabolic syndrome , 2012, Nature Medicine.
[22] M. Karlsson,et al. Pharmacokinetic‐Pharmacodynamic Assessment of the Interrelationships Between Tesaglitazar Exposure and Renal Function in Patients With Type 2 Diabetes Mellitus , 2012, Journal of clinical pharmacology.
[23] L. Delbridge,et al. Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles. , 2011, Cellular signalling.
[24] J. Olefsky,et al. Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones , 2011, Nature Medicine.
[25] S. Woods,et al. A role for CNS PPARγ in the regulation of energy balance , 2011, Nature Medicine.
[26] T. Lan,et al. Internalization Dissociates β2-Adrenergic Receptors , 2011, PloS one.
[27] D. Grobbee,et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis , 2010, The Lancet.
[28] J. Geddes,et al. What is a randomised controlled trial? , 2009, Epidemiologia e Psichiatria Sociale.
[29] E. Wolf,et al. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. , 2009, American journal of physiology. Renal physiology.
[30] R. Printz,et al. Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis. , 2009, Endocrinology.
[31] R. Ratner,et al. Efficacy, safety and tolerability of tesaglitazar when added to the therapeutic regimen of poorly controlled insulin-treated patients with type 2 diabetes , 2007, Diabetes & vascular disease research.
[32] H. Bays,et al. A double-blind, randomised trial of tesaglitazar versus pioglitazone in patients with type 2 diabetes mellitus , 2007, Diabetes & vascular disease research.
[33] John P H Wilding,et al. Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes , 2007, Diabetes & vascular disease research.
[34] B. Göke,et al. The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes , 2007, Diabetes & vascular disease research.
[35] D. Hum,et al. Safety issues and prospects for future generations of PPAR modulators. , 2007, Biochimica et biophysica acta.
[36] D. Decamp,et al. Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway* , 2007, Journal of Biological Chemistry.
[37] B. Staels,et al. PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome , 2006 .
[38] R. DeFronzo,et al. Improvement of Glycemic Control, Triglycerides, and HDL Cholesterol Levels With Muraglitazar, a Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy , 2006, Diabetes Care.
[39] Erland Erdmann,et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial , 2005, The Lancet.
[40] J. Miyazaki,et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. , 1990, Endocrinology.
[41] J. Huttunen,et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. , 1987, The New England journal of medicine.
[42] B. Staels,et al. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD , 2017, Nature Reviews Endocrinology.
[43] A. Secher,et al. Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. , 2015, Endocrinology.
[44] B. Staels,et al. PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome. , 2006, Current opinion in pharmacology.
[45] R. DeFronzo,et al. Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-compa , 2006, Diabetes care.
[46] J. Rosenstock,et al. Effect of tesaglitazar, a dual PPAR alpha/gamma agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial. , 2006, Current medical research and opinion.
[47] P. Allhoff,et al. Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle Aged Men with Dyslipidemia , 1991 .