Questioning the use of an age‐adjusted D‐dimer threshold to exclude venous thromboembolism: analysis of individual patient data from two diagnostic studies

Essentials It is unclear if raising the D‐dimer level to exclude venous thrombosis in older patients is valid. We compared this ‘age‐adjusted’ strategy with other ways of interpreting D‐dimer results. A non‐age adjusted increase, and using higher thresholds in younger patients, was just as accurate. Age‐adjustment of D‐dimer thresholds does not appear to be appropriate.

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