Increased CCL18 expression in patients with cutaneous T‐cell lymphoma: association with disease severity and prognosis

Background  CC chemokine ligand (CCL) 18 is expressed by monocytes and dendritic cells (DCs), and has potent chemotactic activity for T cells, B cells and DCs. CCL18 expression is up‐regulated in lesional skin of atopic dermatitis and bullous pemphigoid, suggesting its important roles in the development of these skin diseases.

[1]  M. Meurer,et al.  Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma. , 2011, The American journal of pathology.

[2]  Wolfram Sterry,et al.  Pathogenesis of Mycosis fungoides , 2011, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[3]  K. Hon,et al.  Exploring CCL18, eczema severity and atopy , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[4]  M. Ewen,et al.  CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. , 2011, Cancer cell.

[5]  Wei Zhang,et al.  Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified , 2011, Leukemia & lymphoma.

[6]  Shinichi Sato,et al.  Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. , 2010, The Journal of investigative dermatology.

[7]  N. Yawalkar,et al.  High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphoma. , 2010, Journal of the American Academy of Dermatology.

[8]  C. Lam,et al.  Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis. , 2010, International immunology.

[9]  Steven J. M. Jones,et al.  Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. , 2010, The New England journal of medicine.

[10]  Min‐Geol Lee,et al.  CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy , 2010, Experimental dermatology.

[11]  C. Günther,et al.  CCL18 is expressed in patients with bullous pemphigoid and parallels disease course , 2009, The British journal of dermatology.

[12]  M. Netea,et al.  Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion , 2009, Scandinavian journal of rheumatology.

[13]  H. Nilsson‐Ehle,et al.  Expression of CD68+ tumor‐associated macrophages in patients with diffuse large B‐cell lymphoma and its relation to prognosis , 2008, Pathology international.

[14]  J. H. Lee,et al.  Increased expression of CC chemokine ligand 18 in extrinsic atopic dermatitis patients , 2007, Experimental dermatology.

[15]  T. Kuzel,et al.  Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  J. Carucci,et al.  Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. , 2007, The Journal of allergy and clinical immunology.

[17]  A. Blauvelt,et al.  Oncostatin M Enhances CCL21 Expression by Microvascular Endothelial Cells and Increases the Efficiency of Dendritic Cell Trafficking to Lymph Nodes1 , 2006, The Journal of Immunology.

[18]  T. Kuzel,et al.  A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides. , 2006, Journal of the American Academy of Dermatology.

[19]  M. Sugaya,et al.  Elevated serum CTACK/CCL27 levels in CTCL. , 2006, The Journal of investigative dermatology.

[20]  J. Pollard,et al.  Distinct role of macrophages in different tumor microenvironments. , 2006, Cancer research.

[21]  J. Van Damme,et al.  Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes , 2005, Journal of leukocyte biology.

[22]  Nicola Pimpinelli,et al.  WHO-EORTC classification for cutaneous lymphomas. , 2005, Blood.

[23]  L. Showe,et al.  Immunopathogenesis and therapy of cutaneous T cell lymphoma. , 2005, The Journal of clinical investigation.

[24]  T. Biedermann,et al.  CCL18 Is Expressed in Atopic Dermatitis and Mediates Skin Homing of Human Memory T Cells , 2005, The Journal of Immunology.

[25]  W. Fridman,et al.  CC Chemokine Ligand 18, An Atopic Dermatitis-Associated and Dendritic Cell-Derived Chemokine, Is Regulated by Staphylococcal Products and Allergen Exposure1 , 2004, The Journal of Immunology.

[26]  H. Takamori,et al.  Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[27]  J. Travers,et al.  Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. , 2003, The Journal of allergy and clinical immunology.

[28]  G. Goteri,et al.  Density of neoplastic lymphoid infiltrate, CD8+ T cells, and CD1a+ dendritic cells in mycosis fungoides , 2003, Journal of clinical pathology.

[29]  A. Mantovani,et al.  Unique Regulation of CCL18 Production by Maturing Dendritic Cells1 , 2003, The Journal of Immunology.

[30]  E. Papadavid,et al.  The relevance of peripheral blood T‐helper 1 and 2 cytokine pattern in the evaluation of patients with mycosis fungoides and Sézary syndrome , 2003, The British journal of dermatology.

[31]  K. Matsushima,et al.  High level of thymus and activation‐regulated chemokine in blister fluid and sera of patients with bullous pemphigoid , 2003, The British journal of dermatology.

[32]  M. Dhodapkar,et al.  The growth of cutaneous T-cell lymphoma is stimulated by immature dendritic cells. , 2002, Blood.

[33]  P. Puddu,et al.  Increased expression of eotaxin and its specific receptor CCR3 in bullous pemphigoid. , 2002, European journal of dermatology : EJD.

[34]  Y. Shimada,et al.  Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis , 2001, Archives of Dermatological Research.

[35]  C. Figdor,et al.  The Dendritic Cell-Specific CC-Chemokine DC-CK1 Is Expressed by Germinal Center Dendritic Cells and Attracts CD38-Negative Mantle Zone B Lymphocytes , 2001, The Journal of Immunology.

[36]  Koichiro Nakamura,et al.  Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. , 2001, The Journal of allergy and clinical immunology.

[37]  E. Bröcker,et al.  Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity. , 2001, The American journal of pathology.

[38]  B. Antus,et al.  Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. , 2000, Cellular immunology.

[39]  Antonio Lanzavecchia,et al.  Distinct patterns and kinetics of chemokine production regulate dendritic cell function , 1999, European journal of immunology.

[40]  S. Goerdt,et al.  Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. , 1998, Journal of immunology.

[41]  Y. Sakaki,et al.  A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. , 1997, Journal of immunology.

[42]  T. Mcclanahan,et al.  A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells , 1997, Nature.

[43]  M. Peitsch,et al.  The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases , 1997, Journal of leukocyte biology.

[44]  A. Rook,et al.  Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine Th2 cells. , 1992, The Journal of investigative dermatology.

[45]  R. Martí,et al.  Prognostic clinicopathologic factors in cutaneous T-cell lymphoma. , 1991, Archives of dermatology.

[46]  P. Bunn,et al.  Phase II study of recombinant human interferon gamma for treatment of cutaneous T-cell lymphoma. , 1990, Journal of the National Cancer Institute.

[47]  R. Jordon,et al.  Bullous pemphigoid: a cause of peripheral blood eosinophilia. , 1983, Journal of the American Academy of Dermatology.

[48]  M. G. Lewis,et al.  Target Role of Langerhans Cells in Mycosis Fungoides: Transmission and Immuno‐Electron Microscopic Studies , 1979, Journal of cutaneous pathology.

[49]  Koichiro Nakamura,et al.  Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides: serum TARC levels reflect the disease activity of mycosis fungoides. , 2003, Journal of the American Academy of Dermatology.

[50]  G. Burg,et al.  Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. , 2002, Journal of the American Academy of Dermatology.

[51]  E. Vonderheid,et al.  Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma. Clinical and prognostic implications. , 1996, Archives of dermatology.

[52]  R. Winkelmann,et al.  Atopic dermatitis and Sézary syndrome. , 1984, Archives of dermatology.