论文信息 - Multiple sclerosis associated agent (MSAA)

Multiple sclerosis associated agent (MSAA)

Article abstract-Recent reports indicate that a multiple sclerosis agent (MSAA) has been isolated. This agent was detected in mice by a depression in the percentage of mouse polymorphonuclear neutrophils (PMNs). We attempted to repeat these studies using coded specimens. The test, itself, was extremely variable and difficult to reproduce. In the first study, three of three multiple sclerosis (MS) patients and one of two control patients' specimens showed some PMN depression. In a repeat study of these same samples, one of three MS patients and one of two controls were associated with PMN depression. With a second set of coded specimens, one of four MS patients, one of three patients with neurologic diseases, and none of three controls showed PMN depression. We were unable to confirm the presence of MSAA and conclude that the results were random.

W. Tourtellotte | J. Sever | D. Madden | M. Gravell | A. Krezlewicz

[1] R. Ackermann,et al. Multiple sclerosis-associated agent: transmission to animals and some properties of the agent , 1975, Infection and immunity.

[2] R. Ackermann,et al. Multiple sclerosis-associated agent: neutralization of the agent by human sera , 1975, Infection and immunity.

[3] A. Trudgett,et al. Mouse granulocyte precursors and multiple sclerosis , 1974, Nature.

[4] P. Brown,et al. No Mouse PMN Leukocyte Depression after Inoculation with Brain Tissue from Multiple Sclerosis or Spongiform Encephalopathies , 1974, Nature.

[5] R. Carp,et al. Scrapie-Induced Changes in the Percentage of Polymorphonuclear Neutrophils in Mouse Peripheral Blood , 1972, Infection and immunity.