The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.

[1]  O. Dormond,et al.  Mechanosensitive mTORC1 signaling maintains lymphatic valves , 2023, The Journal of cell biology.

[2]  C. Betsholtz,et al.  Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner , 2022, bioRxiv.

[3]  H. Reichenspurner,et al.  Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia , 2021, Redox biology.

[4]  S. Stritt,et al.  Homeostatic maintenance of the lymphatic vasculature. , 2021, Trends in molecular medicine.

[5]  Yan Wang,et al.  Biological Significance of NOTCH Signaling Strength , 2021, Frontiers in Cell and Developmental Biology.

[6]  T. Renné,et al.  EVL regulates VEGF receptor‐2 internalization and signaling in developmental angiogenesis , 2021, EMBO reports.

[7]  B. Bardoni,et al.  Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders , 2021, Molecular Psychiatry.

[8]  L. Claesson‐Welsh,et al.  Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies. , 2020, Trends in molecular medicine.

[9]  S. Stritt,et al.  EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity , 2020, eLife.

[10]  J. Kipnis,et al.  The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease , 2020, Cell.

[11]  Maike Frye,et al.  The Importance of Mechanical Forces for in vitro Endothelial Cell Biology , 2020, Frontiers in Physiology.

[12]  H. Ozaki,et al.  Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats , 2020, Hypertension.

[13]  A. Eichmann,et al.  Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases , 2020, Frontiers in Physiology.

[14]  A. Lenzi,et al.  PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis , 2020, International journal of molecular sciences.

[15]  Joshua D. Wythe,et al.  S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling , 2020, bioRxiv.

[16]  Giovanni Parmigiani,et al.  ComBat-seq: batch effect adjustment for RNA-seq count data , 2020, bioRxiv.

[17]  Juan M. Vaquerizas,et al.  Endothelial EphB4 maintains vascular integrity and transport function in adult heart , 2019, eLife.

[18]  D. Lowy,et al.  DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis , 2019, Oncogene.

[19]  G. Baillie,et al.  Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond , 2019, Nature Reviews Drug Discovery.

[20]  Jing Wang,et al.  WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs , 2019, Nucleic Acids Res..

[21]  S. Butz,et al.  Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds , 2018, The EMBO journal.

[22]  James T. Webber,et al.  Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris , 2018, Nature.

[23]  Leland McInnes,et al.  UMAP: Uniform Manifold Approximation and Projection , 2018, J. Open Source Softw..

[24]  Chuanlu Jiang,et al.  Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT) , 2018, BMC Neurology.

[25]  Anna Szymborska,et al.  Hold Me, but Not Too Tight-Endothelial Cell-Cell Junctions in Angiogenesis. , 2018, Cold Spring Harbor perspectives in biology.

[26]  M. Pellegrini,et al.  Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers , 2018, The Journal of cell biology.

[27]  M. Komatsu,et al.  Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  A. Soricelli,et al.  Critical role of phosphodiesterase 2A in mouse congenital heart defects , 2018, Cardiovascular research.

[29]  Liqun He,et al.  Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program , 2018, Nature Communications.

[30]  K. Alitalo,et al.  Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms , 2018, Nature Communications.

[31]  K. Guan,et al.  PDE2 at the crossway between cAMP and cGMP signalling in the heart. , 2017, Cellular signalling.

[32]  H. Kokubo,et al.  Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. , 2017, Journal of medicinal chemistry.

[33]  J. Huot,et al.  The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells. , 2017, Oncotarget.

[34]  M. Potente,et al.  Vascular heterogeneity and specialization in development and disease , 2017, Nature Reviews Molecular Cell Biology.

[35]  S. Huveneers,et al.  Cell–cell junctional mechanotransduction in endothelial remodeling , 2016, Cellular and Molecular Life Sciences.

[36]  P. Buijnsters,et al.  Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present) , 2016, Expert opinion on therapeutic patents.

[37]  J. Fischer,et al.  Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. , 2016, Circulation research.

[38]  M. Colonna,et al.  CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. , 2016, The Journal of clinical investigation.

[39]  A. Zarbock,et al.  Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin , 2015, The Journal of experimental medicine.

[40]  P. Scambler,et al.  Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect , 2015, Prenatal diagnosis.

[41]  B. Fu,et al.  Reinforcing endothelial junctions prevents microvessel permeability increase and tumor cell adhesion in microvessels in vivo , 2015, Scientific Reports.

[42]  Ronald N. Germain,et al.  Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity , 2015, Cell.

[43]  M. Delorenzi,et al.  FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. , 2015, The Journal of clinical investigation.

[44]  D. Takai,et al.  Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer , 2015, Cancer medicine.

[45]  P. Davies,et al.  Lymph flow regulates collecting lymphatic vessel maturation in vivo. , 2015, The Journal of clinical investigation.

[46]  M. Hill,et al.  Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling. , 2015, Cardiovascular research.

[47]  M. Nussenzweig,et al.  Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells , 2015, The Journal of Immunology.

[48]  Kyu-Sung Choi,et al.  Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2 , 2015, Nature Communications.

[49]  S. Lehnart,et al.  Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy. , 2015, Circulation research.

[50]  A. Regev,et al.  Spatial reconstruction of single-cell gene expression , 2015, Nature Biotechnology.

[51]  A. Hadjantonakis,et al.  Murine Notch1 is required for lymphatic vascular morphogenesis during development , 2014, Developmental dynamics : an official publication of the American Association of Anatomists.

[52]  M. Sugaya,et al.  Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells. , 2014, Journal of dermatological science.

[53]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[54]  J. Kitajewski,et al.  Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium , 2013, Development.

[55]  R. Weinberg,et al.  The distribution of phosphodiesterase 2A in the rat brain , 2012, Neuroscience.

[56]  J. Ridgway,et al.  The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development. , 2011, Blood.

[57]  Alberto Smith,et al.  Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. , 2011, The Journal of clinical investigation.

[58]  K. Alitalo,et al.  Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. , 2011, Blood.

[59]  M. Lohse,et al.  FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells , 2011, Nature Protocols.

[60]  J. Breslin ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction. , 2011, Lymphatic research and biology.

[61]  M. Haubitz,et al.  Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells , 2010, BMC Cell Biology.

[62]  A. Engler,et al.  Preparation of Hydrogel Substrates with Tunable Mechanical Properties , 2010, Current protocols in cell biology.

[63]  R. Adams,et al.  DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. , 2009, Blood.

[64]  J. Tien,et al.  Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes. , 2008, Microvascular research.

[65]  Elisabetta Dejana,et al.  Functionally specialized junctions between endothelial cells of lymphatic vessels , 2007, The Journal of experimental medicine.

[66]  J. Beavo,et al.  Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. , 2007, Annual review of biochemistry.

[67]  J. Beavo,et al.  Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3 , 2007, Circulation research.

[68]  Jiahuai Han,et al.  Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin αIIbβ3 , 2006 .

[69]  D. Vestweber,et al.  Association of Csk to VE‐cadherin and inhibition of cell proliferation , 2005, The EMBO journal.

[70]  H. Barth,et al.  cAMP protects endothelial barrier functions by preventing Rac-1 inhibition. , 2004, American journal of physiology. Heart and circulatory physiology.

[71]  B. Clurman,et al.  Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21Cip1 Repression , 2004, Molecular and Cellular Biology.

[72]  L. Favot,et al.  VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors , 2003, Thrombosis and Haemostasis.

[73]  M. Corada,et al.  Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148 , 2003, The Journal of cell biology.

[74]  Taro Matsumoto,et al.  p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2–stimulated angiogenesis , 2002, The Journal of cell biology.

[75]  R. Hammer,et al.  Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. , 2001, Developmental biology.

[76]  Reynaldo Sequerra,et al.  High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP , 2000, Nature Genetics.

[77]  R. Ye,et al.  Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase* , 2000, The Journal of Biological Chemistry.

[78]  M. M. Appleman,et al.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain. , 1971, Biochemistry.

[79]  T. Petrova,et al.  Characterization of Mouse Mesenteric Lymphatic Valve Structure and Function. , 2018, Methods in molecular biology.

[80]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[81]  J. Beavo,et al.  Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases. , 2011, Handbook of experimental pharmacology.

[82]  Manuela Zaccolo,et al.  of in The Role of the in the A Molecular for Generating cAMP and cGMP Signaling Cross-Talk Role of Phosphodiesterases and Implications for Cardiac Pathophysiology , 2007 .