Contributions of Wiskott–Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation
暂无分享,去创建一个
[1] A. Villa,et al. Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome. , 2009, Blood.
[2] H. Nakauchi,et al. The Actin Polymerization Regulator WAVE2 Is Required for Early Bone Marrow Repopulation by Hematopoietic Stem Cells , 2009, Stem cells.
[3] A. Schulz,et al. The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function , 2009, The Journal of experimental medicine.
[4] A. Bretscher,et al. T cell antigen receptor signaling and immunological synapse stability require myosin IIA , 2009, Nature Immunology.
[5] K. Siminovitch,et al. The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis1 , 2009, The Journal of Immunology.
[6] S. Ward,et al. Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation. , 2009, The Biochemical journal.
[7] K. Siminovitch,et al. Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils. , 2009, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[8] B. Goode,et al. Actin nucleation and elongation factors: mechanisms and interplay. , 2009, Current opinion in cell biology.
[9] S. Jameson,et al. Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development , 2009, Science.
[10] F. Candotti,et al. Revertant somatic mosaicism in the Wiskott–Aldrich syndrome , 2009, Immunologic research.
[11] L. Notarangelo,et al. Primary immune deficiencies with aberrant IgE production. , 2008, The Journal of allergy and clinical immunology.
[12] H. D. Liggitt,et al. A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity , 2008, The Journal of experimental medicine.
[13] C. Brautigam,et al. Hierarchical regulation of WASP/WAVE proteins. , 2008, Molecular cell.
[14] S. Remold,et al. Evolution of Highly Polymorphic T Cell Populations in Siblings with the Wiskott-Aldrich Syndrome , 2008, PloS one.
[15] Jason S. Mitchell,et al. The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1 , 2008, The Journal of cell biology.
[16] Jens V Stein,et al. How chemokines invite leukocytes to dance , 2008, Nature Immunology.
[17] David A. Williams,et al. Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. , 2008, Blood.
[18] Wendell A. Lim,et al. The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency , 2008, Nature.
[19] V. Kuchroo,et al. Induction and effector functions of TH17 cells , 2008, Nature.
[20] Alissa M. Weaver,et al. N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses* , 2008, Journal of Biological Chemistry.
[21] A. Thrasher,et al. Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[22] J. Condeelis,et al. WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells , 2008, The Journal of cell biology.
[23] K. Rottner,et al. Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front , 2008, Nature Cell Biology.
[24] B. Isaac,et al. Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2 , 2008, Journal of Cell Science.
[25] S. Burns,et al. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. , 2007, Blood.
[26] B. Trask,et al. Human Subtelomeric WASH Genes Encode a New Subclass of the WASP Family , 2007, PLoS genetics.
[27] D. St Johnston,et al. Capu and Spire Assemble a Cytoplasmic Actin Mesh that Maintains Microtubule Organization in the Drosophila Oocyte , 2007, Developmental cell.
[28] R. Mullins,et al. Regulatory interactions between two actin nucleators, Spire and Cappuccino , 2007, The Journal of cell biology.
[29] C. Klein,et al. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. , 2007, Gastroenterology.
[30] H. Higgs,et al. The many faces of actin: matching assembly factors with cellular structures , 2007, Nature Cell Biology.
[31] R. Xavier,et al. Wiskott–Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development , 2007, Proceedings of the National Academy of Sciences.
[32] J. Orange,et al. Cdc42-interacting protein–4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse , 2007, The Journal of experimental medicine.
[33] Christine Kinnon,et al. Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia , 2007, The Journal of experimental medicine.
[34] K. Siminovitch,et al. T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out Mice* , 2007, Journal of Biological Chemistry.
[35] N. Minato,et al. Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1 , 2007, The Journal of experimental medicine.
[36] S. Schmid,et al. SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. , 2007, Developmental cell.
[37] Jason S. Mitchell,et al. WAVE2 Regulates High-Affinity Integrin Binding by Recruiting Vinculin and Talin to the Immunological Synapse , 2007, Molecular and Cellular Biology.
[38] Jake M. Hofman,et al. Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse , 2007, Cell.
[39] M. Krummel. Immunological Synapses: Breaking Up May Be Good to Do , 2007, Cell.
[40] Sumio Sugano,et al. Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis , 2007, Cell.
[41] Thomas D Pollard,et al. Regulation of actin filament assembly by Arp2/3 complex and formins. , 2007, Annual review of biophysics and biomolecular structure.
[42] A. Rudensky,et al. Foxp3 in control of the regulatory T cell lineage , 2007, Nature Immunology.
[43] H. Higgs,et al. Dia-Interacting Protein Modulates Formin-Mediated Actin Assembly at the Cell Cortex , 2007, Current Biology.
[44] A. Rudensky,et al. Thymic development and peripheral homeostasis of regulatory T cells. , 2007, Current opinion in immunology.
[45] John T. Chang,et al. Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses , 2007, Science.
[46] John G. Collard,et al. The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization , 2007, The Journal of cell biology.
[47] J. Guan,et al. A Novel Role of the Actin-nucleating Arp2/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription* , 2007, Journal of Biological Chemistry.
[48] P. Leibson,et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. , 2007, Immunity.
[49] S. Snapper,et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells , 2007, The Journal of experimental medicine.
[50] L. Notarangelo,et al. WASP regulates suppressor activity of human and murine CD4+CD25+FOXP3+ natural regulatory T cells , 2007, The Journal of experimental medicine.
[51] K. Wood,et al. Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2. , 2007, Biochemistry.
[52] S. Ziegler,et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. , 2007, The Journal of clinical investigation.
[53] D. Billadeau,et al. Regulation of T-cell activation by the cytoskeleton , 2007, Nature Reviews Immunology.
[54] G. Mills,et al. Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells , 2007, Proceedings of the National Academy of Sciences.
[55] D. Yamazaki,et al. Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. , 2006, Journal of biochemistry.
[56] D. Yamazaki,et al. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion , 2006, Journal of Cell Science.
[57] L. Notarangelo,et al. Defective Th1 Cytokine Gene Transcription in CD4+ and CD8+ T Cells from Wiskott-Aldrich Syndrome Patients1 , 2006, The Journal of Immunology.
[58] Matthew F Krummel,et al. Maintenance and modulation of T cell polarity , 2006, Nature Immunology.
[59] David A. Williams,et al. RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development , 2006, Nature Immunology.
[60] D. Billadeau,et al. Regulation of Cytoskeletal Dynamics at the Immune Synapse: New Stars Join the Actin Troupe , 2006, Traffic.
[61] Matthew D. Welch,et al. The ARP2/3 complex: an actin nucleator comes of age , 2006, Nature Reviews Molecular Cell Biology.
[62] M. Carlier,et al. Characterization of TccP‐mediated N‐WASP activation during enterohaemorrhagic Escherichia coli infection , 2006, Cellular microbiology.
[63] P. Greengard,et al. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology , 2006, Nature.
[64] D. Danilenko,et al. Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis , 2006, Science.
[65] S. Simon,et al. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. , 2006, Immunity.
[66] Rajat Varma,et al. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. , 2006, Immunity.
[67] Takashi Saito,et al. Immunological synapse and microclusters: the site for recognition and activation of T cells. , 2006, Current opinion in immunology.
[68] S. Tsuboi,et al. A Complex of Wiskott-Aldrich Syndrome Protein with Mammalian Verprolins Plays an Important Role in Monocyte Chemotaxis1 , 2006, The Journal of Immunology.
[69] R. Grosse,et al. Staying in shape with formins. , 2006, Developmental cell.
[70] A. Shaw,et al. Immune synapses in T-cell activation. , 2006, Current opinion in immunology.
[71] M. Way,et al. Signaling During Pathogen Infection , 2006, Science's STKE.
[72] J. Orange,et al. Formation of a WIP-, WASp-, actin-, and myosin IIA–containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling , 2006, The Journal of cell biology.
[73] G. Gutman,et al. The sense of place in the immune system , 2006, Nature Immunology.
[74] Mariko Sawa,et al. Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. , 2006, Biochemical and biophysical research communications.
[75] M. Rosen,et al. Protein-tyrosine Kinase and GTPase Signals Cooperate to Phosphorylate and Activate Wiskott-Aldrich Syndrome Protein (WASP)/Neuronal WASP* , 2006, Journal of Biological Chemistry.
[76] R. Geha,et al. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. , 2006, International immunology.
[77] Y. Hayashi,et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. , 2006, Immunity.
[78] S. Gygi,et al. Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis , 2006, PLoS biology.
[79] Shiro Suetsugu,et al. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis , 2006, The Journal of cell biology.
[80] B. Freedman,et al. The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation , 2006, Current Biology.
[81] P. Zipfel,et al. Role for the Abi/Wave Protein Complex in T Cell Receptor-Mediated Proliferation and Cytoskeletal Remodeling , 2006, Current Biology.
[82] W. Song,et al. Interaction of SPIN90 with the Arp2/3 Complex Mediates Lamellipodia and Actin Comet Tail Formation* , 2006, Journal of Biological Chemistry.
[83] A. Wittinghofer,et al. The regulation of mDia1 by autoinhibition and its release by Rho•GTP , 2005, The EMBO journal.
[84] Bianca Habermann,et al. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. , 2005, Developmental cell.
[85] R. Geha,et al. Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. , 2005, The Journal of allergy and clinical immunology.
[86] K. Mossman,et al. Altered TCR Signaling from Geometrically Repatterned Immunological Synapses , 2005, Science.
[87] B. Isaac,et al. A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages , 2005, Journal of Cell Science.
[88] D. Perrais,et al. Dynamics of endocytic vesicle creation. , 2005, Developmental cell.
[89] M. Ahmadian,et al. An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins. , 2005, Molecular cell.
[90] Rajat Varma,et al. Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling , 2005, The Journal of experimental medicine.
[91] K. Rottner,et al. Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes , 2005, Nature Cell Biology.
[92] K. Rottner,et al. N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits , 2005, Journal of Cell Science.
[93] D. Yamazaki,et al. Regulation of cancer cell motility through actin reorganization , 2005, Cancer science.
[94] F. Alt,et al. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo , 2005, Journal of leukocyte biology.
[95] David Zenisek,et al. Coupling between Clathrin-Coated-Pit Invagination, Cortactin Recruitment, and Membrane Scission Observed in Live Cells , 2005, Cell.
[96] R. Thapar,et al. Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. , 2005, Biochemistry.
[97] M. Machius,et al. Structural basis of Rho GTPase-mediated activation of the formin mDia1. , 2005, Molecular cell.
[98] P. Doherty,et al. WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. , 2005, Experimental hematology.
[99] M. McNiven,et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse , 2005, Nature Immunology.
[100] R. Mullins,et al. Drosophila Spire is an actin nucleation factor , 2005, Nature.
[101] K. Siminovitch,et al. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[102] Sandra L Schmid,et al. A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. , 2004, Molecular biology of the cell.
[103] K. Siminovitch,et al. Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell activation. , 2004, Seminars in immunology.
[104] W. Vainchenker,et al. Mechanisms of WASp-mediated hematologic and immunologic disease. , 2004, Blood.
[105] Roberto A. Maldonado,et al. A role for the immunological synapse in lineage commitment of CD4 lymphocytes , 2004, Nature.
[106] E. Caron,et al. Regulation of WASP/WAVE proteins , 2004, The Journal of cell biology.
[107] J. Cannon,et al. Differential Roles for Wiskott-Aldrich Syndrome Protein in Immune Synapse Formation and IL-2 Production1 , 2004, The Journal of Immunology.
[108] J. Leong,et al. EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. , 2004, Developmental cell.
[109] S. Gygi,et al. Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP Complex , 2004, Cell.
[110] L. Notarangelo,et al. Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect. , 2004, Blood.
[111] K. Siminovitch,et al. Cutting Edge: Selective Requirement for the Wiskott-Aldrich Syndrome Protein in Cytokine, but Not Chemokine, Secretion by CD4+ T Cells1 , 2004, The Journal of Immunology.
[112] D. Schafer. Regulating Actin Dynamics at Membranes: A Focus on Dynamin , 2004, Traffic.
[113] D. Sage,et al. EBV attachment stimulates FHOS/FHOD1 redistribution and co-aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21 , 2004, Journal of Cell Science.
[114] D. Yamazaki,et al. PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia , 2004, Nature Cell Biology.
[115] Wei Xu,et al. A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting. , 2004, Journal of molecular biology.
[116] Andrea Disanza,et al. Abi1 is essential for the formation and activation of a WAVE2 signalling complex , 2004, Nature Cell Biology.
[117] M. Vartiainen,et al. The WASP-Arp2/3 pathway: genetic insights. , 2004, Current opinion in cell biology.
[118] E. Remold-O’Donnell,et al. Early deficit of lymphocytes in Wiskott–Aldrich syndrome: possible role of WASP in human lymphocyte maturation , 2004, Clinical and experimental immunology.
[119] S. Gygi,et al. Purification and architecture of the ubiquitous Wave complex. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[120] S. Narumiya,et al. Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells , 2004, Science.
[121] R. Kay,et al. The RhoA‐ and CDC42‐specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double‐positive and single‐positive thymocytes , 2004, European journal of immunology.
[122] K. Rottner,et al. Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation , 2004, The EMBO journal.
[123] Harvey T. McMahon,et al. The dynamin superfamily: universal membrane tubulation and fission molecules? , 2004, Nature Reviews Molecular Cell Biology.
[124] Miguel Vicente-Manzanares,et al. Role of the cytoskeleton during leukocyte responses , 2004, Nature Reviews Immunology.
[125] K. Siminovitch,et al. Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation , 2004, The Journal of experimental medicine.
[126] Å. Engqvist-Goldstein,et al. Actin assembly and endocytosis: from yeast to mammals. , 2003, Annual review of cell and developmental biology.
[127] Arup K Chakraborty,et al. The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.
[128] S. Saad,et al. Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt. , 2003, Biochemical and biophysical research communications.
[129] David G. Drubin,et al. A Pathway for Association of Receptors, Adaptors, and Actin during Endocytic Internalization , 2003, Cell.
[130] P. Doherty,et al. Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells. , 2003, Blood.
[131] B. Baum,et al. Abi, Sra1, and Kette Control the Stability and Localization of SCAR/WAVE to Regulate the Formation of Actin-Based Protrusions , 2003, Current Biology.
[132] T. Takenawa,et al. Translocation of N-WASP by Nuclear Localization and Export Signals into the Nucleus Modulates Expression of HSP90* , 2003, Journal of Biological Chemistry.
[133] R. Vale,et al. Molecular requirements for actin-based lamella formation in Drosophila S2 cells , 2003, The Journal of cell biology.
[134] H. Yin,et al. Regulation of Sustained Actin Dynamics by the TCR and Costimulation as a Mechanism of Receptor Localization , 2003, The Journal of Immunology.
[135] T. Takenawa,et al. Regulation of actin dynamics by WASP family proteins. , 2003, Journal of biochemistry.
[136] E. Haddad,et al. A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. , 2003, Blood.
[137] H. Higgs,et al. The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition , 2003, Current Biology.
[138] Michael Way,et al. SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site 1 , 2003, The Journal of Immunology.
[139] S. Nishikawa,et al. WAVE2 is required for directed cell migration and cardiovascular development , 2003, Nature.
[140] F. Alt,et al. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility , 2003, The EMBO journal.
[141] H. Tojo,et al. The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa. , 2003, Molecular endocrinology.
[142] H. Ljunggren,et al. Efficient antigen presentation of soluble, but not particulate, antigen in the absence of Wiskott–Aldrich syndrome protein , 2003, Immunology.
[143] F. Candotti,et al. Autoimmunity in Wiskott-Aldrich syndrome , 2003, Current opinion in rheumatology.
[144] Michael J. Byrne,et al. WIP participates in actin reorganization and ruffle formation induced by PDGF , 2003, Journal of Cell Science.
[145] K. Schwarz,et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. , 2003, Pediatrics.
[146] K. Siminovitch,et al. The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation , 2003, Immunological reviews.
[147] M. McNiven,et al. Cortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis , 2003, Molecular and Cellular Biology.
[148] T. Takenawa,et al. Neural Wiskott-Aldrich Syndrome Protein Is Recruited to Rafts and Associates with Endophilin A in Response to Epidermal Growth Factor* , 2003, The Journal of Biological Chemistry.
[149] Thomas D Pollard,et al. Cellular Motility Driven by Assembly and Disassembly of Actin Filaments , 2003, Cell.
[150] M. Gandhi,et al. X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP). , 2003, Experimental hematology.
[151] Jack E. Dixon,et al. Sorting out the cellular functions of sorting nexins , 2003, Nature Reviews Molecular Cell Biology.
[152] Michael J. Byrne,et al. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. , 2002, Molecular cell.
[153] A. Ridley,et al. Phosphorylation of Tyrosine 291 Enhances the Ability of WASp to Stimulate Actin Polymerization and Filopodium Formation* , 2002, The Journal of Biological Chemistry.
[154] W. Lim,et al. Structure of the N-WASP EVH1 Domain-WIP Complex Insight into the Molecular Basis of Wiskott-Aldrich Syndrome , 2002, Cell.
[155] M. Kessels,et al. Syndapins integrate N‐WASP in receptor‐mediated endocytosis , 2002, The EMBO journal.
[156] Shiro Suetsugu,et al. Sustained activation of N-WASP through phosphorylation is essential for neurite extension. , 2002, Developmental cell.
[157] K. Rottner,et al. Phosphatidylinositol 4,5-Biphosphate (PIP2)-induced Vesicle Movement Depends on N-WASP and Involves Nck, WIP, and Grb2* 210 , 2002, The Journal of Biological Chemistry.
[158] D. Zaller,et al. Staging and resetting T cell activation in SMACs , 2002, Nature Immunology.
[159] Adrian J. Thrasher,et al. Wasp in immune-system organization and function , 2002, Nature Reviews Immunology.
[160] W. Almers,et al. Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits , 2002, Nature Cell Biology.
[161] Alexandre V. Podtelejnikov,et al. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck , 2002, Nature.
[162] Michael J. Byrne,et al. Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[163] Anjana Rao,et al. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes , 2002, Nature Immunology.
[164] Balbino Alarcón,et al. Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation , 2002, Cell.
[165] Charles Boone,et al. Role of Formins in Actin Assembly: Nucleation and Barbed-End Association , 2002, Science.
[166] R. Germain. T-cell development and the CD4–CD8 lineage decision , 2002, Nature Reviews Immunology.
[167] Michael Loran Dustin,et al. T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.
[168] T. Takenawa,et al. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. , 2002, Biochemical and biophysical research communications.
[169] K. Siminovitch,et al. WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[170] M. Tremblay,et al. PSTPIP Is a Substrate of PTP-PEST and Serves as a Scaffold Guiding PTP-PEST Toward a Specific Dephosphorylation of WASP* , 2002, The Journal of Biological Chemistry.
[171] S. Szabo,et al. Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells , 2002, Science.
[172] K. Siminovitch,et al. The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis , 2001, The Journal of experimental medicine.
[173] J. Westendorf. The Formin/Diaphanous-related Protein, FHOS, Interacts with Rac1 and Activates Transcription from the Serum Response Element* , 2001, The Journal of Biological Chemistry.
[174] G. Griffiths,et al. The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.
[175] P. Chavrier,et al. A WASp–VASP complex regulates actin polymerization at the plasma membrane , 2001, The EMBO journal.
[176] S. Antonarakis,et al. Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP , 2001, Nature Cell Biology.
[177] D. Cantrell,et al. Analysis of Thymocyte Development Reveals That the Gtpase Rhoa Is a Positive Regulator of T Cell Receptor Responses in Vivo , 2001, The Journal of experimental medicine.
[178] M. Aepfelbacher,et al. The Verprolin-like Central (VC) Region of Wiskott-Aldrich Syndrome Protein Induces Arp2/3 Complex-dependent Actin Nucleation* , 2001, The Journal of Biological Chemistry.
[179] M. Kirschner,et al. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[180] Toshikazu Shirai,et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration , 2001, Nature.
[181] Gerra L. Bosco,et al. Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. , 2001, Immunity.
[182] M. Kirschner,et al. Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway* , 2001, The Journal of Biological Chemistry.
[183] J. Hartwig,et al. WIP regulates N-WASP-mediated actin polymerization and filopodium formation , 2001, Nature Cell Biology.
[184] T. Takenawa,et al. Requirement of the basic region of N-WASP/WAVE2 for actin-based motility. , 2001, Biochemical and biophysical research communications.
[185] T. Takenawa,et al. A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42 , 2001, The Journal of cell biology.
[186] T. Takenawa,et al. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling , 2000, Nature.
[187] W. Lim,et al. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. , 2000, Science.
[188] M. McNiven,et al. Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape , 2000, The Journal of cell biology.
[189] D. Cantrell,et al. Control of pre-T cell proliferation and differentiation by the GTPase Rac-1 , 2000, Nature Immunology.
[190] M. Bevan,et al. Role of chemokines in thymocyte development. , 2000, Seminars in immunology.
[191] S. Zigmond,et al. Profilin Enhances Cdc42-Induced Nucleation of Actin Polymerization , 2000, The Journal of cell biology.
[192] R. Kelly,et al. Molecular Links between Endocytosis and the Actin Cytoskeleton , 2000, The Journal of cell biology.
[193] H. Riezman,et al. An intact SH3 domain is required for myosin I‐induced actin polymerization , 2000, The EMBO journal.
[194] P. Sansonetti,et al. GRB2 Links Signaling to Actin Assembly by Enhancing Interaction of Neural Wiskott-Aldrich Syndrome Protein (N-WASp) with Actin-related Protein (ARP2/3) Complex* , 2000, The Journal of Biological Chemistry.
[195] F. Frischknecht,et al. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization , 2000, Nature Cell Biology.
[196] J. Wehland,et al. Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton , 2000, The Journal of cell biology.
[197] D. Nelson,et al. Cdc42-interacting Protein 4 Mediates Binding of the Wiskott-Aldrich Syndrome Protein to Microtubules* , 2000, The Journal of Biological Chemistry.
[198] Michael K. Rosen,et al. Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein , 2000, Nature.
[199] K. Sano,et al. Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23). , 2000, Blood.
[200] K. Siminovitch,et al. Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes , 1999, The Journal of experimental medicine.
[201] F. Sánchez‐Madrid,et al. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes , 1999, European journal of immunology.
[202] T. Pollard,et al. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. , 1999, Biochemistry.
[203] C. Sasakawa,et al. Wiskott-Aldrich Syndrome Protein Induces Actin Clustering without Direct Binding to Cdc42* , 1999, The Journal of Biological Chemistry.
[204] U. Walter,et al. The EVH2 Domain of the Vasodilator-stimulated Phosphoprotein Mediates Tetramerization, F-actin Binding, and Actin Bundle Formation* , 1999, The Journal of Biological Chemistry.
[205] A. Fedorov,et al. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function , 1999, Nature Structural Biology.
[206] T. Takenawa,et al. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. , 1999, Biochemical and biophysical research communications.
[207] K. Siminovitch,et al. Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein , 1999, Nature.
[208] M. Kirschner,et al. The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly , 1999, Cell.
[209] M. Davis,et al. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. , 1998, Science.
[210] E. Reinherz,et al. A cdc15‐like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2‐triggered adhesion , 1998, The EMBO journal.
[211] Shiro Suetsugu,et al. WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac , 1998, The EMBO journal.
[212] Y. Tu,et al. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. , 1998, Molecular biology of the cell.
[213] T. Takenawa,et al. The essential role of profilin in the assembly of actin for microspike formation , 1998, The EMBO journal.
[214] B. Mayer,et al. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. , 1998, Immunity.
[215] M. L. Le Beau,et al. Identification of Nck Family Genes, Chromosomal Localization, Expression, and Signaling Specificity* , 1998, The Journal of Biological Chemistry.
[216] C. Saxe,et al. SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium Development , 1998, The Journal of cell biology.
[217] Patricia L. Widder,et al. A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts , 1998, Cell.
[218] Colin R. F. Monks,et al. Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.
[219] Philip R. Cohen,et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. , 1998, Immunity.
[220] C. Lowell,et al. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[221] Dunn,et al. Chemotaxis of macrophages is abolished in the Wiskott‐Aldrich syndrome , 1998, British journal of haematology.
[222] K. Tedford,et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor , 1998, Current Biology.
[223] H. Schneider,et al. CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. , 1998, Journal of immunology.
[224] Yoshimi Takai,et al. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP , 1998, Nature.
[225] J. Hartwig,et al. WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[226] J. Wehland,et al. A novel proline‐rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family , 1997, The EMBO journal.
[227] B. Margolis,et al. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. , 1997, Molecular biology of the cell.
[228] K. Nakao,et al. p140mDia, a mammalian homolog of Drosophila diaphanous,is a target protein for Rho small GTPase and is a ligand for profilin , 1997, The EMBO journal.
[229] A. Hall,et al. The GTPase Rho has a critical regulatory role in thymus development , 1997, The EMBO journal.
[230] M. Gallego,et al. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. , 1997, Blood.
[231] K. Schuebel,et al. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product , 1997, Nature.
[232] J. Wehland,et al. Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics , 1996, Cell.
[233] K. Miura,et al. N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases. , 1996, The EMBO journal.
[234] I. Gout,et al. Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases , 1996, Current Biology.
[235] U. Francke,et al. Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization , 1996, Cell.
[236] A. Marcilla,et al. Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains , 1995, Molecular and cellular biology.
[237] K. Takase,et al. [T cell activation]. , 1995, Ryumachi. [Rheumatism].
[238] J. Chant,et al. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[239] G. Roberto Burgio,et al. The Wiskott-Aldrich syndrome , 1995, European Journal of Pediatrics.
[240] Wendell A. Lim,et al. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains , 1995, Nature.
[241] A. Lanzavecchia,et al. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton , 1995, The Journal of experimental medicine.
[242] U. Francke,et al. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome , 1994, Cell.
[243] C. Terhorst,et al. T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses. , 1993, Journal of immunology.
[244] K. Siminovitch,et al. Linkage of the Wiskott-Aldrich syndrome with polymorphic DNA sequences from the human X chromosome. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[245] Fanny Marhuenda,et al. CONTACTS , 1967 .
[246] D. Billadeau,et al. T cell activation and the cytoskeleton: you can't have one without the other. , 2008, Advances in immunology.
[247] Shiro Suetsugu,et al. The WASP–WAVE protein network: connecting the membrane to the cytoskeleton , 2007, Nature Reviews Molecular Cell Biology.
[248] G. Koretzky,et al. The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. , 2007, Blood.
[249] R. Mullins,et al. Regulatory interactions between two actin nucleators, , 2007 .
[250] G. Koretzky,et al. SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond , 2006, Nature Reviews Immunology.
[251] S. Fuller,et al. Centrosome polarization delivers secretory granules to the immunological synapse , 2006, Nature.
[252] V. Barr,et al. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton , 2005, Nature Immunology.
[253] K. Siminovitch,et al. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. , 2003, Immunity.
[254] T. Pollard,et al. Cellular Motility Driven by Assembly and Disassembly of Actin Filaments , 2003, Cell.
[255] Eric J Kunkel,et al. Chemokines and the tissue-specific migration of lymphocytes. , 2002, Immunity.
[256] R. Mullins,et al. Cellular control of actin nucleation. , 2002, Annual review of cell and developmental biology.
[257] K. Schwarz,et al. The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis. , 2001, Blood.
[258] T D Pollard,et al. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. , 2001, Annual review of biochemistry.
[259] Thomas D. Pollard,et al. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex , 2000, Nature Cell Biology.
[260] G. Crabtree,et al. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. , 1998, Immunity.
[261] Uno Lindberg,et al. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome , 1996, Current Biology.
[262] Jonathan A. Cooper,et al. Control of actin assembly at filament ends. , 1995, Annual review of cell and developmental biology.