The search for chlorinated dibenzofurans and chlorinated dibenzodioxins in wildlife populations showing elevated levels of embryonic death.

Various kinds of reproductive abnormalities have been documented among wildlife species in North America. All are associated with areas of high agricultural or industrial activity and have been shown, or are assumed to be, pollutant-induced. Selected wildlife populations may therefore serve as the best indicators of the presence in the environment of compounds which have deleterious effects on organisms at very low concentrations, such as several of the chlorinated dibenzo-p-dioxins and chlorinated dibenzofurans. The best documented of the abnormalities observed in wildlife is the shell thinning of eggs of raptorial and fish-eating species of birds. Contemporary samples show a significant increase in the variance of such parameters as shell weight, shell thickness and an index of shell thickness when com-

[1]  Bowes Gw,et al.  Industrial chemicals. Extraction of polychlorinated biphenyls: evaluation of a column technique applied to polar bear and seal tissue. , 1974 .

[2]  W. Gilmartin,et al.  Premature Births in California Sea Lions: Association with High Organochlorine Pollutant Residue Levels , 1973, Science.

[3]  D. H. Smith,et al.  Application of real-time mass spectrometric techniques to environmental organic geochemistry II. Organic matter in San Francisco bay area water , 1973, Archives of environmental contamination and toxicology.

[4]  O. Hutzinger,et al.  Contamination of the Bay of Fundy—Gulf of Maine area with Polychlorinated Biphenyls, Polychlorinated Terphenyls, Chlorinated Dibenzodioxins, and Dibenzofurans , 1972, Environmental health perspectives.

[5]  J. G. Vos.  Toxicology of PCBs for Mammals and for Birds , 1972, Environmental health perspectives.

[6]  D. Anderson,et al.  Eggshell changes in certain North American birds , 1972 .

[7]  R. Risebrough,et al.  Pollutant Concentrations in Abnormal Young Terns from Long Island Sound , 1972 .

[8]  R. Risebrough.  Effects of environmental pollutants upon animals other than man , 1972 .

[9]  Port-Lis Ml,et al.  Industrial chemicals. Separation of three chlorodibenzo-p-dioxins from some polychlorinated biphenyls by chromatography on an aluminum oxide column. , 1971 .

[10]  Dennis H. Smith,et al.  Real-time mass spectrometry. LOGOS, a generalized mass spectrometry computer system for high and low resolution, gas chromatography/mass spectrometry, and closed-loop applications , 1971 .

[11]  J. A. Burke,et al.  Industrial chemicals. Separation of three chlorodibenzo-p-dioxins from some polychlorinated biphenyls by chromatography on an aluminum oxide column. , 1971, Journal - Association of Official Analytical Chemists.

[12]  V. K. Rowe,et al.  Study of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. , 1971, Food and cosmetics toxicology.

[13]  J. Koeman,et al.  Comparative toxicologic study with polychlorinated biphenyls in chickens with special reference to porphyria, edema formation, liver necrosis, and tissue residues. , 1970, Toxicology and applied pharmacology.

[14]  D. H. Smith,et al.  Real-Time High-Resolution Mass Spectrometry , 1970 .

[15]  A. L. Burlingame,et al.  Developments and applications of real-time high resolution mass spectrometry , 1970 .

[16]  M. C. ten Noever de Brauw,et al.  Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls. , 1970, Food and cosmetics toxicology.

[17]  J. A. Keith.  Reproduction in a population of herring gulls (Larus argentatus) contaminated by DDT , 1966 .