Iloprost, a stable prostacyclin analog, reduces intraocular pressure.

Topical application of Iloprost caused a dose-dependent decrease in intraocular pressure (IOP) in rabbits and ocular hypertensive beagles. In rabbits, the IOP response was biphasic and miosis was observed. In beagles, there was no initial hypertensive phase, and the fall in IOP was more pronounced (up to 37%). In beagles, Iloprost did not influence pupillary diameter. A mild transient hyperemia was noted in both rabbit and beagle eyes. Iloprost led to an increase in the aqueous humor protein concentration in rabbits but not in beagles. The use of artificial tears as vehicle enhanced the effect on intraocular pressure but also aqueous protein in rabbits. The central corneal temperature was increased after application of Iloprost in both rabbits and beagles. In rabbits, tonography revealed an increase in outflow facility during both the hypertensive and the hypotensive phases. Iloprost caused a decrease in mean arterial pressure in beagles; the effect on pulse rate was inconsequential. It is suggested that similar low doses of an analog of Iloprost or carboprostacyclin that does not affect the hemodynamic equilibrium could be of value in the treatment of glaucoma.

[1]  K. Schrör,et al.  The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) — Equipotent to PGI2 in vitro , 1981, Naunyn-Schmiedeberg's Archives of Pharmacology.

[2]  P. Hoyng,et al.  Topical prostaglandins inhibit trauma-induced inflammation in the rabbit eye. , 1986, Investigative ophthalmology & visual science.

[3]  K. Green,et al.  Ocular blood flow after experimental alkali burns and prostaglandin administration. , 1985, A M A Archives of Ophthalmology.

[4]  F. J. Hoyng.  The effect of topical prostacyclin on ocular pressure and pupil size in the pigmented rabbit. , 1985, Experimental Eye Research.

[5]  S. Podos,et al.  Effect of prostaglandin F2 alpha on aqueous humor dynamics of rabbit, cat, and monkey. , 1984, Investigative ophthalmology & visual science.

[6]  L. Bito.  Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. , 1984, Experimental eye research.

[7]  J. Barbenel,et al.  The Novel Effect of a New Prostacyclin Analogue ZK36374 on the Aggregation of Human Platelets in Whole Blood , 1983, Thrombosis and Haemostasis.

[8]  J. Parratt,et al.  Prostacyclin—Antiarrhythmic or Arrhythmogenic? Comparison of the Effects of Intravenous and Intracoronary Prostacyclin and ZK36374 During Coronary Artery Occlusion and Reperfusion in Anaesthetised Greyhounds , 1983, Journal of cardiovascular pharmacology.

[9]  C. Camras,et al.  Long-term maintenance of reduced intraocular pressure by daily or twice daily topical application of prostaglandins to cat or rhesus monkey eyes. , 1983, Investigative ophthalmology & visual science.

[10]  P. Kulkarni,et al.  The effect of intravitreal and topical prostaglandins on intraocular inflammation. , 1982, Investigative ophthalmology & visual science.

[11]  L. Bito,et al.  Comparison of the hypotensive and other ocular effects of prostaglandins E2 and F2 alpha on cat and rhesus monkey eyes. , 1982, Investigative ophthalmology & visual science.

[12]  R. Moses,et al.  Prostaglandin E2 effect on the facility of outflow in the rabbit eye. , 1981, Annals of ophthalmology.

[13]  C. Camras,et al.  Reduction of intraocular pressure in normal and glaucomatous primate (Aotus trivirgatus) eyes by topically applied prostaglandin F2 alpha. , 1981, Current eye research.

[14]  C. Camras,et al.  Reduction of intraocular pressure by prostaglandins applied topically to the eyes of conscious rabbits. , 1977, Investigative ophthalmology & visual science.

[15]  K. Eakins,et al.  Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier. , 1977, Experimental eye research.

[16]  J. Vane,et al.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. , 1976, Prostaglandins.

[17]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[18]  M. Sears,et al.  Adenosine 3',5'-monophosphate increases the outflow of aqueous humor from the rabbit eye. , 1975, Investigative ophthalmology.

[19]  K. Green,et al.  Pattern of ocular response to topical and systemic prostaglandin. , 1975, Investigative ophthalmology.

[20]  J. Lamble,et al.  Letter: A detailed assessment procedure of anti-inflammatory effects of drugs on experimental immunogenic uveitis in rabbits. , 1974, Investigative ophthalmology.

[21]  M. Kass,et al.  Prostaglandin E 1 and aqueous humor dynamics. , 1972, Investigative ophthalmology.

[22]  K. Masuda.  [Effects of prostaglandins on inflow and outflow of aqueous humor in rabbits]. , 1972, Nippon Ganka Gakkai zasshi.

[23]  M. Starr,et al.  Effects of prostaglandins and a prostaglandin antagonist on intraocular pressure and protein in the monkey eye. , 1971, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[24]  K. Eakins,et al.  Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye. , 1970, Experimental eye research.

[25]  R Mapstone,et al.  Determinants of corneal temperature. , 1968, The British journal of ophthalmology.

[26]  M. Waitzman,et al.  Prostaglandin influences on intraocular pressure and pupil size. , 1967, The American journal of physiology.

[27]  M. Hogan,et al.  Signs and symptoms of uveitis. I. Anterior uveitis. , 1959, American journal of ophthalmology.

[28]  E. Perkins,et al.  FURTHER STUDIES ON THE DISTENSIBILITY OF THE EYE* , 1957, The British journal of ophthalmology.

[29]  E. Perkins,et al.  DISTENSIBILITY OF THE EYE* , 1957, The British journal of ophthalmology.