Antibiotic Discovery and Development
暂无分享,去创建一个
[1] E. Murphy. Nucleotide sequence of ermA, a macrolide-lincosamide-streptogramin B determinant in Staphylococcus aureus , 1985, Journal of bacteriology.
[2] A. Driessen,et al. Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria , 2007, Microbiology and Molecular Biology Reviews.
[3] S. Levy,et al. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. , 1999, Trends in microbiology.
[4] A. Kwon,et al. Induction of ermAMR from a Clinical Strain of Enterococcus faecalis by 16-Membered-Ring Macrolide Antibiotics , 1998, Journal of bacteriology.
[5] H. Wexler,et al. BmeRABC5 is a multidrug efflux system that can confer metronidazole resistance in Bacteroides fragilis. , 2007, Microbial drug resistance.
[6] H. Nikaido,et al. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein , 2003, Molecular microbiology.
[7] Jane W. Marsh,et al. Outer Membrane Protein Changes and Efflux Pump Expression Together May Confer Resistance to Ertapenem in Enterobacter cloacae , 2006, Antimicrobial Agents and Chemotherapy.
[8] M. Desai,et al. Synthesis and antibacterial activity of novel C12 ethyl ketolides. , 2006, Bioorganic & medicinal chemistry.
[9] H. Wexler,et al. Bile salts enhance bacterial co-aggregation, bacterial-intestinal epithelial cell adhesion, biofilm formation and antimicrobial resistance of Bacteroides fragilis. , 2007, Microbial pathogenesis.
[10] Hui-Feng Chen,et al. Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. , 2004, The Journal of antimicrobial chemotherapy.
[11] Liying Sun,et al. Differential susceptibility to carbapenems due to the AdeABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital. , 2008, Diagnostic microbiology and infectious disease.
[12] S. Levy,et al. Ineffectiveness of Topoisomerase Mutations in Mediating Clinically Significant Fluoroquinolone Resistance inEscherichia coli in the Absence of the AcrAB Efflux Pump , 2000, Antimicrobial Agents and Chemotherapy.
[13] D. Livermore,et al. Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems. , 2005, The Journal of antimicrobial chemotherapy.
[14] D. Daigle,et al. Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415 , 2005, Antimicrobial Agents and Chemotherapy.
[15] W. Kern,et al. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. , 2006, The Journal of antimicrobial chemotherapy.
[16] Qijing Zhang,et al. Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. , 2006, The Journal of antimicrobial chemotherapy.
[17] E. Bokma,et al. Structure of the periplasmic component of a bacterial drug efflux pump. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[18] D. Dubnau,et al. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics. , 1984, CRC critical reviews in biochemistry.
[19] J. Ruiz,et al. Effect of the efflux pump inhibitor Phe-Arg-beta-naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin. , 2004, The Journal of antimicrobial chemotherapy.
[20] M. Matsuoka,et al. Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter. , 1999, FEMS microbiology letters.
[21] P. Tulkens,et al. A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa. , 2007, The Journal of antimicrobial chemotherapy.
[22] D. Vazquez,et al. Cooperative and antagonistic interactions of peptidyl-tRNA and antibiotics with bacterial ribosomes. , 1977, European journal of biochemistry.
[23] F. Ausubel,et al. Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. , 2006, ACS chemical biology.
[24] W. Watkins,et al. Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria. , 2001, Journal of molecular microbiology and biotechnology.
[25] S. Levy,et al. MarA-Like Regulator of Multidrug Resistance in Yersinia pestis , 2006, Antimicrobial Agents and Chemotherapy.
[26] S. Levy,et al. Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli. , 1998, FEMS microbiology letters.
[27] N. Masuda,et al. Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa , 2000, Antimicrobial Agents and Chemotherapy.
[28] David A. D'Argenio,et al. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[29] J. Aínsa,et al. Role of mycobacterial efflux transporters in drug resistance: an unresolved question. , 2006, FEMS microbiology reviews.
[30] K. Poole,et al. Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. , 2001, Current topics in medicinal chemistry.
[31] A. Kwon,et al. Translational Attenuation and mRNA Stabilization as Mechanisms of erm(B) Induction by Erythromycin , 2008, Antimicrobial Agents and Chemotherapy.
[32] N. Høiby,et al. Occurrence of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation , 2005, Antimicrobial Agents and Chemotherapy.
[33] L. Herman,et al. Mechanisms of erythromycin resistance of Campylobacter spp. isolated from food, animals and humans. , 2007, International journal of food microbiology.
[34] J. Vila,et al. Partial characterisation of the acrAB locus in two Citrobacter freundii clinical isolates. , 2007, International journal of antimicrobial agents.
[35] D. Dubnau,et al. Translational attenuation of ermC: A deletion analysis , 1982, Molecular and General Genetics MGG.
[36] M. N. Huda,et al. An RND-type multidrug efflux pump SdeXY from Serratia marcescens. , 2003, The Journal of antimicrobial chemotherapy.
[37] P. Nordmann,et al. Detection and Prevalence of Active Drug Efflux Mechanism in Various Multidrug-Resistant Klebsiella pneumoniae Strains from Turkey , 2004, Journal of Clinical Microbiology.
[38] Y. Arakawa,et al. Plasmid-Mediated qepA Gene among Escherichia coli Clinical Isolates from Japan , 2008, Antimicrobial Agents and Chemotherapy.
[39] S. Sørensen,et al. Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria. , 2007, The Journal of antimicrobial chemotherapy.
[40] K. Yokoyama,et al. Plasmid-Mediated 16S rRNA Methylase in Serratia marcescens Conferring High-Level Resistance to Aminoglycosides , 2004, Antimicrobial Agents and Chemotherapy.
[41] S. Gibbons,et al. Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis. , 2008, The Journal of antimicrobial chemotherapy.
[42] M. Maniati,et al. Spread of efflux pump-overexpressing, non-metallo-beta-lactamase-producing, meropenem-resistant but ceftazidime-susceptible Pseudomonas aeruginosa in a region with blaVIM endemicity. , 2005, The Journal of antimicrobial chemotherapy.
[43] J. Ruiz,et al. Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O:3 clinical isolates. , 2004, The Journal of antimicrobial chemotherapy.
[44] R. Zarivach,et al. Structural basis for the antibiotic activity of ketolides and azalides. , 2003, Structure.
[45] Mark Webber,et al. Phenotypic and Proteomic Characterization of Multiply Antibiotic-Resistant Variants of Salmonella enterica Serovar Typhimurium Selected Following Exposure to Disinfectants , 2007, Applied and Environmental Microbiology.
[46] David L. Steffen,et al. Mechanisms Accounting for Fluoroquinolone Resistance in Escherichia coli Clinical Isolates , 2008, Antimicrobial Agents and Chemotherapy.
[47] E. Cundliffe,et al. Transcriptional attenuation control of the tylosin‐resistance gene tlrA in Streptomyces fradiae , 1994, Molecular microbiology.
[48] B. Wretlind,et al. Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa. , 1998, Microbial drug resistance.
[49] Didier Hocquet,et al. Involvement of the MexXY-OprM Efflux System in Emergence of Cefepime Resistance in Clinical Strains of Pseudomonas aeruginosa , 2006, Antimicrobial Agents and Chemotherapy.
[50] J. Pagés,et al. Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates. , 2003, The Biochemical journal.
[51] W. Shafer,et al. Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli , 2008, Antimicrobial Agents and Chemotherapy.
[52] D. Klepacki,et al. Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center. , 2011, Molecular cell.
[53] B. Wretlind,et al. Expression of the MexXY efflux pump in amikacin-resistant isolates of Pseudomonas aeruginosa. , 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[54] A. Begum,et al. Gene Cloning and Characterization of Four MATE Family Multidrug Efflux Pumps from Vibrio cholerae Non‐O1 , 2005, Microbiology and immunology.
[55] M. Mulvey,et al. AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104 , 2004, Antimicrobial Agents and Chemotherapy.
[56] D. Hoban,et al. Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae , 2003, Expert opinion on emerging drugs.
[57] M. Roberts. Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics , 2004, Molecular biotechnology.
[58] C. Cagliero,et al. Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli. , 2005, Journal of Antimicrobial Chemotherapy.
[59] P. Bradford,et al. A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline , 2005, Antimicrobial Agents and Chemotherapy.
[60] R. Leclercq,et al. Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin. , 1999, The Journal of antimicrobial chemotherapy.
[61] Peng Ding-hui. Carbapenem resistance mechanisms of Pseudomonas aeruginosa , 2010 .
[62] F. Yoshimura,et al. Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance. , 2006, The Journal of antimicrobial chemotherapy.
[63] H. Schweizer,et al. High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux. , 2003, American journal of infection control.
[64] T. Mah,et al. Involvement of a Novel Efflux System in Biofilm-Specific Resistance to Antibiotics , 2008, Journal of bacteriology.
[65] D. Dubnau,et al. DNA sequence and regulation of ermD, a macrolide-lincosamide-streptogramin B resistance element from Bacillus licheniformis , 1984, Molecular and General Genetics MGG.
[66] Yun-Jeong Choi,et al. Heterogeneity of Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Enterococci , 2003, Antimicrobial Agents and Chemotherapy.
[67] M. Perić,et al. Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of Haemophilus influenzae Clinical Isolates , 2003, Antimicrobial Agents and Chemotherapy.
[68] A. Wong-Beringer,et al. Use of an Efflux Pump Inhibitor To Determine the Prevalence of Efflux Pump-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa , 2005, Antimicrobial Agents and Chemotherapy.
[69] Jun Lin,et al. Effect of an efflux pump inhibitor on the function of the multidrug efflux pump CmeABC and antimicrobial resistance in Campylobacter. , 2006, Foodborne pathogens and disease.
[70] Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S. , 2004, The Journal of antimicrobial chemotherapy.
[71] H. Luís,et al. Staphylococcus Efflux msr(A) Gene Characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas Isolates , 2006, Antimicrobial Agents and Chemotherapy.
[72] S. Halling,et al. Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications , 2006, BMC Microbiology.
[73] P. Courvalin,et al. Transferable Resistance to Aminoglycosides by Methylation of G1405 in 16S rRNA and to Hydrophilic Fluoroquinolones by QepA-Mediated Efflux in Escherichia coli , 2007, Antimicrobial Agents and Chemotherapy.
[74] K. Poole,et al. SmeC, an Outer Membrane Multidrug Efflux Protein of Stenotrophomonas maltophilia , 2002, Antimicrobial Agents and Chemotherapy.
[75] G. Doern. Macrolide and ketolide resistance with Streptococcus pneumoniae. , 2006, The Medical clinics of North America.
[76] F. Schluenzen,et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria , 2001, Nature.
[77] K. Poole. Efflux pumps as antimicrobial resistance mechanisms , 2007, Annals of medicine.
[78] Marilyn Roberts,et al. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance , 2001, Microbiology and Molecular Biology Reviews.
[79] A. Marchese,et al. European Emergence of Ciprofloxacin-Resistant Escherichia coli Clonal Groups O25:H4-ST 131 and O15:K52:H1 Causing Community-Acquired Uncomplicated Cystitis , 2008, Journal of Clinical Microbiology.
[80] J. Ramos. Genomics, life style and molecular architecture , 2004 .
[81] N. Masuda,et al. Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa. , 1999, Antimicrobial Agents and Chemotherapy.
[82] K. Poole. Efflux-mediated antimicrobial resistance. , 2005, The Journal of antimicrobial chemotherapy.
[83] K. Poole,et al. MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa: Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor , 2008, Antimicrobial Agents and Chemotherapy.
[84] M. Ehrenberg,et al. The Molecular Mechanism of Peptide-mediated Erythromycin Resistance* , 2006, Journal of Biological Chemistry.
[85] G. Bammert,et al. Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors , 2008, Antimicrobial Agents and Chemotherapy.
[86] D. Young,et al. Molecular Cloning and Functional Analysis of a Novel Tetracycline Resistance Determinant, tet(V), fromMycobacterium smegmatis , 1998, Antimicrobial Agents and Chemotherapy.
[87] M. Ehrenberg,et al. Kinetics of Macrolide Action , 2004, Journal of Biological Chemistry.
[88] Y. Y. Chan,et al. BpeAB-OprB, a Multidrug Efflux Pump in Burkholderia pseudomallei , 2004, Antimicrobial Agents and Chemotherapy.
[89] K. Poole,et al. Mutations in PA2491 (mexS) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa , 2005, Journal of bacteriology.
[90] M. Niederweis,et al. Identification of a Novel Multidrug Efflux Pump of Mycobacterium tuberculosis , 2008, Antimicrobial Agents and Chemotherapy.
[91] S. Horinouchi,et al. A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis , 1983, Journal of bacteriology.
[92] J. Pagés,et al. New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. , 2001, Journal of medicinal chemistry.
[93] W. Whittington,et al. Acquired macrolide resistance genes and the 1 bp deletion in the mtrR promoter in Neisseria gonorrhoeae. , 2003, The Journal of antimicrobial chemotherapy.
[94] C. Chiu,et al. Resistance to fluoroquinolones linked to gyrA and par C mutations and overexpression of acr AB efflux pump in Salmonella enterica serotype Choleraesuis. , 2005, Microbial drug resistance.
[95] T. Tsuchiya,et al. Molecular Cloning and Characterization of All RND‐Type Efflux Transporters in Vibrio cholerae Non‐O1 , 2007, Microbiology and immunology.
[96] I. Paulsen,et al. RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine , 2008, Antimicrobial Agents and Chemotherapy.
[97] H. Imberechts,et al. The AcrB multidrug transporter plays a major role in high-level fluoroquinolone resistance in Salmonella enterica serovar typhimurium phage type DT204. , 2002, Microbial drug resistance.
[98] D. Pillay,et al. Analysis of the mechanisms of fluoroquinolone resistance in urinary tract pathogens. , 2006, The Journal of antimicrobial chemotherapy.
[99] J. Vila,et al. Enhanced active efflux, repression of porin synthesis and development of Mar phenotype by diazepam in two enterobacteria strains. , 2004, Journal of medical microbiology.
[100] M. Hänninen,et al. Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli. , 2008, Journal of medical microbiology.
[101] H. Schweizer,et al. Cross-Resistance between Triclosan and Antibiotics inPseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ , 2001, Antimicrobial Agents and Chemotherapy.
[102] S. Yaron,et al. Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion , 2007, Journal of Clinical Microbiology.
[103] K. Poole. Aminoglycoside Resistance in Pseudomonas aeruginosa , 2005, Antimicrobial Agents and Chemotherapy.
[104] M. Putman,et al. Molecular Properties of Bacterial Multidrug Transporters , 2000, Microbiology and Molecular Biology Reviews.
[105] B. Weisblum,et al. Erythromycin-induced stabilization of ermA messenger RNA in Staphylococcus aureus and Bacillus subtilis. , 1988, Journal of molecular biology.
[106] A. Pühler,et al. Plasmid pB8 is closely related to the prototype IncP-1beta plasmid R751 but transfers poorly to Escherichia coli and carries a new transposon encoding a small multidrug resistance efflux protein. , 2005, Plasmid.
[107] C. van Delden,et al. Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ Efflux Pump , 2008, Antimicrobial Agents and Chemotherapy.
[108] Angela Lee,et al. Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa , 1999, Antimicrobial Agents and Chemotherapy.
[109] J. Pagés,et al. A phenylalanine-arginine beta-naphthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides. , 2003, International journal of antimicrobial agents.
[110] P. Stewart,et al. A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance , 2003, Nature.
[111] S. Sørensen,et al. Nucleotide sequence of pOLA52: a conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux. , 2008, Plasmid.
[112] M. Sinha,et al. Mechanisms of resistance to carbapenems in meropenem- resistant Acinetobacter isolates from clinical samples. , 2007, Indian journal of medical microbiology.
[113] B. Bozdoğan,et al. Effect of Efflux on Telithromycin and Macrolide Susceptibility in Haemophilus influenzae , 2006, Antimicrobial Agents and Chemotherapy.
[114] H. Schweizer,et al. Role of the MexXY multidrug efflux pump in moderate aminoglycoside resistance in Pseudomonas aeruginosa isolates from Pseudomonas mastitis , 2008, Microbiology and immunology.
[115] R. Leclercq,et al. Unusual inducible cross resistance to macrolides, lincosamides, and streptogramins B by methylase production in clinical isolates of Staphylococcus aureus. , 2001, Microbial drug resistance.
[116] Q. C. Truong-Bolduc,et al. NorC, a New Efflux Pump Regulated by MgrA of Staphylococcus aureus , 2006, Antimicrobial Agents and Chemotherapy.
[117] K. Poole,et al. Assembly of the MexAB-OprM Multidrug Pump of Pseudomonas aeruginosa: Component Interactions Defined by the Study of Pump Mutant Suppressors , 2007, Journal of bacteriology.
[118] A. Kwon,et al. ermK leader peptide: Amino acid sequence critical for induction by erythromycin , 2006, Archives of pharmacal research.
[119] R. Saito,et al. Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis. , 2006, The Journal of antimicrobial chemotherapy.
[120] B. Weisblum. Erythromycin resistance by ribosome modification , 1995, Antimicrobial agents and chemotherapy.
[121] B. Weisblum,et al. Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae , 1997, Antimicrobial agents and chemotherapy.
[122] Jian-Hua Liu,et al. Coprevalence of Plasmid-Mediated Quinolone Resistance Determinants QepA, Qnr, and AAC(6′)-Ib-cr among 16S rRNA Methylase RmtB-Producing Escherichia coli Isolates from Pigs , 2008, Antimicrobial Agents and Chemotherapy.
[123] H. Hashimoto,et al. Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa , 1992, Antimicrobial Agents and Chemotherapy.
[124] C. Kurland,et al. Elongating ribosomes in vivo are refractory to erythromycin. , 1987, Biochimie.
[125] S. Levy,et al. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones , 1996, Antimicrobial agents and chemotherapy.
[126] Wensi S. Hu,et al. An OXA-66/OXA-51-Like Carbapenemase and Possibly an Efflux Pump Are Associated with Resistance to Imipenem in Acinetobacter baumannii , 2007, Antimicrobial Agents and Chemotherapy.
[127] Identification of novel metronidazole-inducible genes in Mycobacterium smegmatis using a customized amplification library. , 2008, FEMS microbiology letters.
[128] D. Landman,et al. Interplay of Efflux System, ampC, and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical Isolates , 2006, Antimicrobial Agents and Chemotherapy.
[129] R. Hancock,et al. A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa , 1992, Antimicrobial Agents and Chemotherapy.
[130] T. Nishino,et al. nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa , 1995, Antimicrobial agents and chemotherapy.
[131] N. Caroff,et al. Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing beta-lactam resistance. , 2004, FEMS microbiology letters.
[132] F. Ikeda,et al. In Vitro and In Vivo Activities of a New Cephalosporin, FR264205, against Pseudomonas aeruginosa , 2006, Antimicrobial Agents and Chemotherapy.
[133] H. Schweizer. Intrinsic Resistance to Inhibitors of Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Due to Efflux: Application of a Novel Technique for Generation of Unmarked Chromosomal Mutations for the Study of Efflux Systems , 1998, Antimicrobial Agents and Chemotherapy.
[134] I. Paulsen,et al. Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus. , 1992, FEMS microbiology letters.
[135] S. Kachlany,et al. TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter (Actinobacillus) actinomycetemcomitans. , 2007, Gene.
[136] M. Webber,et al. Contribution of Mutation at Amino Acid 45 of AcrR to acrB Expression and Ciprofloxacin Resistance in Clinical and Veterinary Escherichia coli Isolates , 2005, Antimicrobial Agents and Chemotherapy.
[137] K. Poole,et al. Mutations in PA3574 (nalD) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of Pseudomonas aeruginosa , 2005, Antimicrobial Agents and Chemotherapy.
[138] Jian Li,et al. Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. , 2007, The Journal of antimicrobial chemotherapy.
[139] D. Bechhofer,et al. Regulation of the macrolide-lincosamide-streptogramin B resistance gene ermD , 1992, Journal of bacteriology.
[140] M. Mayford,et al. Conformational alterations in the ermC transcript in vivo during induction. , 1989, The EMBO journal.
[141] T. Tsuchiya,et al. NorM of Vibrio parahaemolyticus Is an Na+-Driven Multidrug Efflux Pump , 2000, Journal of bacteriology.
[142] H. K. Dannelly,et al. Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance , 2006, Archives of Microbiology.
[143] F. Rafii,et al. Detection and characterization of an ABC transporter in Clostridium hathewayi , 2008, Archives of Microbiology.
[144] J. Pagés,et al. Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation. , 2007, The Journal of antimicrobial chemotherapy.
[145] M. Braoudaki,et al. Low level of cross-resistance between triclosan and antibiotics in Escherichia coli K-12 and E. coli O55 compared to E. coli O157. , 2004, FEMS microbiology letters.
[146] G. Kaatz,et al. Multidrug Resistance in Staphylococcus aureus Due to Overexpression of a Novel Multidrug and Toxin Extrusion (MATE) Transport Protein , 2005, Antimicrobial Agents and Chemotherapy.
[147] M. McGuckin,et al. Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. , 2008, Journal of medical microbiology.
[148] D. Spelman,et al. In vitro activities of ‘new’ and ‘conventional’ antibiotics against multi‐drug resistant Gram negative bacteria from patients in the intensive care unit , 2007, Pathology (Sydney).
[149] T. Latifi,et al. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium , 2006, Molecular microbiology.
[150] W. Shafer,et al. Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae. , 2005, The Journal of antimicrobial chemotherapy.
[151] P. Bradford,et al. MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. , 2007, The Journal of antimicrobial chemotherapy.
[152] F. Hartl,et al. The dynamic tunnel , 2004, Nature Structural &Molecular Biology.
[153] H. Noller,et al. mRNA Helicase Activity of the Ribosome , 2005, Cell.
[154] B. Weisblum,et al. Insights into erythromycin action from studies of its activity as inducer of resistance , 1995, Antimicrobial agents and chemotherapy.
[155] Satoshi Murakami,et al. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism , 2006, Nature.
[156] D. Hughes,et al. Sampling the Antibiotic Resistome , 2006, Science.
[157] Martha B. Furie,et al. Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence , 2006, Proceedings of the National Academy of Sciences.
[158] D M Crothers,et al. Kinetics of an RNA conformational switch. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[159] L. Peixe,et al. Dissemination of sul3-Containing Elements Linked to Class 1 Integrons with an Unusual 3′ Conserved Sequence Region among Salmonella Isolates , 2007, Antimicrobial Agents and Chemotherapy.
[160] Douglas M. Warner,et al. Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC‐MtrD‐MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness , 2008, Molecular microbiology.
[161] D. Dubnau,et al. Conformational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance. , 1980, Nucleic acids research.
[162] V. Ricci,et al. Ciprofloxacin-Resistant Salmonella enterica Serovar Typhimurium Strains Are Difficult To Select in the Absence of AcrB and TolC , 2006, Antimicrobial Agents and Chemotherapy.
[163] S. Gagné,et al. Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance , 2008, Antimicrobial Agents and Chemotherapy.
[164] A. S. Lynch. Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view. , 2006, Biochemical pharmacology.
[165] C. Cagliero,et al. Synergy between Efflux Pump CmeABC and Modifications in Ribosomal Proteins L4 and L22 in Conferring Macrolide Resistance in Campylobacter jejuni and Campylobacter coli , 2006, Antimicrobial Agents and Chemotherapy.
[166] T. Nakae,et al. Macrolide Antibiotic-Mediated Downregulation of MexAB-OprM Efflux Pump Expression in Pseudomonas aeruginosa , 2008, Antimicrobial Agents and Chemotherapy.
[167] L. Piddock,et al. Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. , 2004, The Journal of antimicrobial chemotherapy.
[168] J. Molnár,et al. An instrument-free method for the demonstration of efflux pump activity of bacteria. , 2006, In vivo.
[169] M. Vecchi,et al. Molecular Characterization of Pneumococci with Efflux-Mediated Erythromycin Resistance and Identification of a Novel mef Gene Subclass, mef(I) , 2005, Antimicrobial Agents and Chemotherapy.
[170] R. Wallace,,et al. Intrinsic Macrolide Resistance in Rapidly Growing Mycobacteria , 2006, Antimicrobial Agents and Chemotherapy.
[171] X. Li,et al. Fluoroquinolone susceptibilities of efflux-mediated multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia. , 2001, The Journal of antimicrobial chemotherapy.
[172] D. Hocquet,et al. Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa. , 2005, The Journal of antimicrobial chemotherapy.
[173] P. Bradford,et al. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. , 2007, The Journal of antimicrobial chemotherapy.
[174] M. Maniati,et al. A highly carbapenem-resistant Pseudomonas aeruginosa isolate with a novel blaVIM-4/blaP1b integron overexpresses two efflux pumps and lacks OprD. , 2007, The Journal of antimicrobial chemotherapy.
[175] M. Hazbón,et al. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol , 2005, Molecular microbiology.
[176] E. Worobec,et al. Characterization of the Serratia marcescens SdeCDE multidrug efflux pump studied via gene knockout mutagenesis. , 2008, Canadian journal of microbiology.
[177] M. Falagas,et al. Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study. , 2008, Respiratory medicine.
[178] M. Mayford,et al. Messenger RNA from Staphylococcus aureus that specifies macrolide-lincosamide-streptogramin resistance. Demonstration of its conformations and of the leader peptide it encodes. , 1985, Journal of molecular biology.
[179] A. Yamaguchi,et al. Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936) , 2004, Antimicrobial Agents and Chemotherapy.
[180] A. Cloeckaert,et al. ramR Mutations Involved in Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium , 2008, Antimicrobial Agents and Chemotherapy.
[181] J. Rood,et al. Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants , 1999, Antimicrobial Agents and Chemotherapy.
[182] L. Martínez-Martínez,et al. Energy-Dependent Accumulation of Fluoroquinolones in Quinolone-Resistant Klebsiella pneumoniaeStrains , 1998, Antimicrobial Agents and Chemotherapy.
[183] E. Houang,et al. Novel Resistance-Nodulation-Cell Division Efflux System AdeDE in Acinetobacter Genomic DNA Group 3 , 2004, Antimicrobial Agents and Chemotherapy.
[184] W. Shafer,et al. Cationic Antimicrobial Peptide Resistance in Neisseria meningitidis , 2005, Journal of bacteriology.
[185] J. Aínsa,et al. Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG. , 2007, The Journal of antimicrobial chemotherapy.
[186] F. Gao,et al. Assessment of efflux pump gene expression in a clinical isolate Mycobacterium tuberculosis by real-time reverse transcription PCR. , 2008, Microbial drug resistance.
[187] P. Nordmann. Plasmid-Mediated Quinolone Resistance , 2008 .
[188] Jean-Marie Pagès,et al. Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy. , 2007, The Journal of antimicrobial chemotherapy.
[189] L. Piddock,et al. Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni. , 2004, The Journal of antimicrobial chemotherapy.
[190] O. Sahin,et al. Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure. , 2006, The Journal of antimicrobial chemotherapy.
[191] K. Poole,et al. Antibiotic Inducibility of the MexXY Multidrug Efflux System of Pseudomonas aeruginosa: Involvement of the Antibiotic-Inducible PA5471 Gene Product , 2006, Journal of bacteriology.
[192] S. Pestka,et al. Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives , 1976, Antimicrobial Agents and Chemotherapy.
[193] I. Lasa,et al. Cloning, Nucleotide Sequencing, and Analysis of the AcrAB-TolC Efflux Pump of Enterobacter cloacae and Determination of Its Involvement in Antibiotic Resistance in a Clinical Isolate , 2007, Antimicrobial Agents and Chemotherapy.
[194] P. Higgins,et al. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. , 2004, The Journal of antimicrobial chemotherapy.
[195] P. Higgins,et al. Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide. , 2006, The Journal of antimicrobial chemotherapy.
[196] S. Falkow,et al. Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium. , 2004, Microbiology.
[197] M. Webber,et al. Triclosan resistance in Salmonella enterica serovar Typhimurium. , 2008, The Journal of antimicrobial chemotherapy.
[198] W. Whittington,et al. Acquired Macrolide Resistance Genes in Pathogenic Neisseria spp. Isolated between 1940 and 1987 , 2003, Antimicrobial Agents and Chemotherapy.
[199] I. Paulsen,et al. Contribution of Target Gene Mutations and Efflux to Decreased Susceptibility of Salmonella enterica Serovar Typhimurium to Fluoroquinolones and Other Antimicrobials , 2006, Antimicrobial Agents and Chemotherapy.
[200] R. Benz,et al. An RND-Type Efflux System in Borrelia burgdorferi Is Involved in Virulence and Resistance to Antimicrobial Compounds , 2008, PLoS pathogens.
[201] J. Karlowsky,et al. Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004). , 2007, The Journal of antimicrobial chemotherapy.
[202] W. Kern,et al. Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in Escherichia coli Overexpressing RND Efflux Pumps , 2005, Antimicrobial Agents and Chemotherapy.
[203] M. Roberts,et al. Tetracycline resistance determinants in Mycobacterium and Streptomyces species , 1994, Antimicrobial Agents and Chemotherapy.
[204] T. Tsuchiya,et al. Molecular Cloning and Characterization of the HmrM Multidrug Efflux Pump from Haemophilus influenzae Rd , 2003, Microbiology and immunology.
[205] M. Akova,et al. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli. , 2006, The Journal of antimicrobial chemotherapy.
[206] W. Kern,et al. Enhanced Expression of the Multidrug Efflux Pumps AcrAB and AcrEF Associated with Insertion Element Transposition in Escherichia coli Mutants Selected with a Fluoroquinolone , 2001, Antimicrobial Agents and Chemotherapy.
[207] A. Rickard,et al. Possible implications of biocide accumulation in the environment on the prevalence of bacterial antibiotic resistance , 2002, Journal of Industrial Microbiology and Biotechnology.
[208] G. Robertson,et al. A Novel Indole Compound That Inhibits Pseudomonas aeruginosa Growth by Targeting MreB Is a Substrate for MexAB-OprM , 2007, Journal of bacteriology.
[209] A. Shafiee,et al. Structural features of new quinolones and relationship to antibacterial activity against Gram-positive bacteria. , 2006, Mini reviews in medicinal chemistry.
[210] N. Ahmed,et al. Mycobacterium tuberculosis Isolate with a Distinct Genomic Identity Overexpresses a Tap-Like Efflux Pump , 2004, Infection.
[211] T. Köhler,et al. OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa , 1995, Antimicrobial agents and chemotherapy.
[212] H. Nikaido,et al. Efflux Pump-Mediated Intrinsic Drug Resistance in Mycobacterium smegmatis , 2004, Antimicrobial Agents and Chemotherapy.
[213] M. Mayford,et al. ermC leader peptide. Amino acid sequence critical for induction by translational attenuation. , 1989, Journal of molecular biology.
[214] A. Cloeckaert,et al. Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium. , 2004, FEMS microbiology letters.
[215] R. Leclercq,et al. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[216] D. Otto,et al. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes , 1982, Antimicrobial Agents and Chemotherapy.
[217] Richard S Larson,et al. Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction. , 2005, Current protein & peptide science.
[218] A. Mankin,et al. The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. , 2007, RNA.
[219] D. Dubnau,et al. Naturally occurring macrolide-lincosamide-streptogramin B resistance in Bacillus licheniformis , 1981, Journal of bacteriology.
[220] Diane E. Taylor,et al. Contribution of the CmeABC Efflux Pump to Macrolide and Tetracycline Resistance in Campylobacter jejuni , 2007, Antimicrobial Agents and Chemotherapy.
[221] P. Lu,et al. Characterization of Fluoroquinolone Resistance Mechanisms and Their Correlation with the Degree of Resistance to Clinically Used Fluoroquinolones among Escherichia coli Isolates , 2007, Journal of chemotherapy.
[222] T. Victor,et al. Isoniazid-Induced Transient High-Level Resistance in Mycobacterium tuberculosis , 2002, Antimicrobial Agents and Chemotherapy.
[223] N. Masuda,et al. Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa , 2000, Antimicrobial Agents and Chemotherapy.
[224] C. Allen,et al. Two Host-Induced Ralstonia solanacearum Genes, acrA and dinF, Encode Multidrug Efflux Pumps and Contribute to Bacterial Wilt Virulence , 2007, Applied and Environmental Microbiology.
[225] W. Shafer,et al. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids. , 1995, Microbiology.
[226] H. Schweizer. Triclosan: a widely used biocide and its link to antibiotics. , 2001, FEMS microbiology letters.
[227] K. Poole,et al. MexAB‐OprM hyperexpression in NalC‐type multidrug‐resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720‐PA3719 , 2004, Molecular microbiology.
[228] D. Livermore. Of Pseudomonas, porins, pumps and carbapenems. , 2001, The Journal of antimicrobial chemotherapy.
[229] C. Andersen,et al. An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations , 2002, Molecular microbiology.
[230] W. Shafer,et al. Decreased Azithromycin Susceptibility ofNeisseria gonorrhoeae Due to mtrRMutations , 1999, Antimicrobial Agents and Chemotherapy.
[231] P. Bradford,et al. Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae , 2005, Antimicrobial Agents and Chemotherapy.
[232] M. Ruiz,et al. Importance of the Efflux Pump Systems in the Resistance of Mycobacterium tuberculosis to Fluoroquinolones and Linezolid , 2007, Chemotherapy.
[233] Qijing Zhang,et al. CmeABC Functions as a Multidrug Efflux System in Campylobacter jejuni , 2002, Antimicrobial Agents and Chemotherapy.
[234] T. Tolker-Nielsen,et al. Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes , 2008, Molecular microbiology.
[235] J. Pagés,et al. Inhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains , 2004, Antimicrobial Agents and Chemotherapy.
[236] M. Dudley,et al. The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors. , 2003, Bioorganic & medicinal chemistry letters.
[237] M. Hänninen,et al. Spontaneous mutation frequency and emergence of ciprofloxacin resistance in Campylobacter jejuni and Campylobacter coli. , 2007, The Journal of antimicrobial chemotherapy.
[238] A. Yamaguchi,et al. Novel Macrolide-Specific ABC-Type Efflux Transporter inEscherichia coli , 2001, Journal of bacteriology.
[239] Douglas M. Warner,et al. Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae. , 2007, The Journal of infectious diseases.
[240] M. Ullrich,et al. Characterization of the RND-Type Multidrug Efflux Pump MexAB-OprM of the Plant Pathogen Pseudomonas syringae , 2008, Applied and Environmental Microbiology.
[241] L. Piddock,et al. Commonly used farm disinfectants can select for mutant Salmonella enterica serovar Typhimurium with decreased susceptibility to biocides and antibiotics without compromising virulence. , 2007, The Journal of antimicrobial chemotherapy.
[242] W. Shafer,et al. Overexpression of the MtrC-MtrD-MtrE Efflux Pump Due to an mtrR Mutation Is Required for Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae , 2002, Journal of bacteriology.
[243] L. Piddock,et al. The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB , 2008, Antimicrobial Agents and Chemotherapy.
[244] N. Groman,et al. Mapping and cloning of Corynebacterium diphtheriae plasmid pNG2 and characterization of its relatedness to plasmids from skin coryneforms , 1986, Antimicrobial Agents and Chemotherapy.
[245] S. Douthwaite,et al. Macrolide Resistance Conferred by Base Substitutions in 23S rRNA , 2001, Antimicrobial Agents and Chemotherapy.
[246] W. Whittington,et al. Identification of the Conjugative mefGene in Clinical Acinetobacter junii and Neisseria gonorrhoeae Isolates , 2000, Antimicrobial Agents and Chemotherapy.
[247] H. Wexler,et al. Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents. , 2007, The Journal of antimicrobial chemotherapy.
[248] Colin Hughes,et al. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export , 2000, Nature.
[249] J. Ravel,et al. Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5 , 2008, Journal of bacteriology.
[250] L. Piddock,et al. Bacterial efflux pump inhibitors from natural sources. , 2007, The Journal of antimicrobial chemotherapy.
[251] A. Mankin,et al. Induction of erm(C) Expression by Noninducing Antibiotics , 2008, Antimicrobial Agents and Chemotherapy.
[252] J. Kowalak,et al. Posttranscriptional Modification of the Central Loop of Domain V in Escherichia coli 23 S Ribosomal RNA (*) , 1995, The Journal of Biological Chemistry.
[253] S. Amyes,et al. Carbapenem Resistance in Clinical Isolates of Pseudomonas aeruginosa , 2007, Journal of chemotherapy.
[254] J. Pagés,et al. Quinoline derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes isolates. , 2006, Current drug targets.
[255] M. Woodward,et al. Association between cyclohexane resistance in Salmonella of different serovars and increased resistance to multiple antibiotics, disinfectants and dyes. , 2001, Journal of medical microbiology.
[256] F. Aarestrup,et al. Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark. , 2008, Microbial drug resistance.
[257] H. H. Xu,et al. Phenotypic and Molecular Characterization of Acinetobacter baumannii Clinical Isolates from Nosocomial Outbreaks in Los Angeles County, California , 2008, Journal of Clinical Microbiology.
[258] P. Courvalin,et al. Expression of the RND-Type Efflux Pump AdeABC in Acinetobacter baumannii Is Regulated by the AdeRS Two-Component System , 2004, Antimicrobial Agents and Chemotherapy.
[259] Angela Lee,et al. Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy , 2001, Antimicrobial Agents and Chemotherapy.
[260] P. Higgins,et al. Fluoroquinolones: structure and target sites. , 2003, Current Drug Targets.
[261] S. Amyes,et al. Role of AcrR and RamA in Fluoroquinolone Resistance in Clinical Klebsiella pneumoniae Isolates from Singapore , 2003, Antimicrobial Agents and Chemotherapy.
[262] J. Verhoef,et al. Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. , 2003, International journal of antimicrobial agents.
[263] J. Pagés,et al. Inhibitors of efflux pumps in Gram-negative bacteria. , 2005, Trends in molecular medicine.
[264] R. Schmid,et al. DNA microarray for genotyping multidrug-resistant Pseudomonas aeruginosa clinical isolates. , 2007, Diagnostic microbiology and infectious disease.
[265] B. Weisblum,et al. Mutant of Staphylococcus aureus with Lincomycin- and Carbomycin-Inducible Resistance to Erythromycin , 1974, Antimicrobial Agents and Chemotherapy.
[266] T. Steitz,et al. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. , 2000, Science.
[267] H. Luís,et al. The mef(A) Gene Predominates among Seven Macrolide Resistance Genes Identified in Gram-Negative Strains Representing 13 Genera, Isolated from Healthy Portuguese Children , 2004, Antimicrobial Agents and Chemotherapy.
[268] D. Provenzano,et al. Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine , 2008, Infection and Immunity.
[269] C. Bailly,et al. Role of the Multidrug Efflux System MexXY in the Emergence of Moderate Resistance to Aminoglycosides among Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis , 2004, Antimicrobial Agents and Chemotherapy.
[270] H. Schweizer,et al. Method for Regulated Expression of Single-Copy Efflux Pump Genes in a Surrogate Pseudomonas aeruginosa Strain: Identification of the BpeEF-OprC Chloramphenicol and Trimethoprim Efflux Pump of Burkholderia pseudomallei 1026b , 2006, Antimicrobial Agents and Chemotherapy.
[271] K. Bostian,et al. Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use. , 2006, Biochemical pharmacology.
[272] T. Tsuchiya,et al. Gene Cloning and Properties of the RND‐Type Multidrug Efflux Pumps MexPQ‐OpmE and MexMN‐OprM from Pseudomonas aeruginosa , 2005, Microbiology and immunology.
[273] H. Ashour,et al. Characterization of Pseudomonas aeruginosa isolated from clinical and environmental samples in Minia, Egypt: prevalence, antibiogram and resistance mechanisms. , 2007, The Journal of antimicrobial chemotherapy.
[274] Yun-juan Chang,et al. Effect of Macrolide Usage on Emergence of Erythromycin-Resistant Campylobacter Isolates in Chickens , 2007, Antimicrobial Agents and Chemotherapy.
[275] Saman Halgamuge,et al. Analysis of SD sequences in completed microbial genomes: non-SD-led genes are as common as SD-led genes. , 2006, Gene.
[276] C. Hotz,et al. Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps. , 2006, Biochemistry.
[277] J. Pagés,et al. The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes , 2002, Antimicrobial Agents and Chemotherapy.
[278] D. Sherman,et al. Characterization of a Pseudomonas aeruginosa Efflux Pump Contributing to Aminoglycoside Impermeability , 1999, Antimicrobial Agents and Chemotherapy.
[279] Amit Ghosh,et al. Mechanism of Drug Resistance in Clonally Related Clinical Isolates of Vibrio fluvialis Isolated in Kolkata, India , 2006, Antimicrobial Agents and Chemotherapy.
[280] Alterations of porin, pumps, and penicillin-binding proteins in carbapenem resistant clinical isolates of Pseudomonas aeruginosa. , 2008, Microbial drug resistance.
[281] S. Sørensen,et al. Plasmid-Encoded Multidrug Efflux Pump Conferring Resistance to Olaquindox in Escherichia coli , 2004, Antimicrobial Agents and Chemotherapy.
[282] K. Poole,et al. SmeDEF Multidrug Efflux Pump Contributes to Intrinsic Multidrug Resistance in Stenotrophomonas maltophilia , 2001, Antimicrobial Agents and Chemotherapy.
[283] N. Masuda,et al. Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa , 2008, Antimicrobial Agents and Chemotherapy.
[284] Matthew E Falagas,et al. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[285] Angela Lee,et al. MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides , 2003, Antimicrobial Agents and Chemotherapy.
[286] Jun Lin,et al. Effect of efflux pump inhibitors on bile resistance and in vivo colonization of Campylobacter jejuni. , 2006, The Journal of antimicrobial chemotherapy.
[287] S. Douthwaite,et al. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[288] D. Hocquet,et al. Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously , 2004, Antimicrobial Agents and Chemotherapy.
[289] P. Bradford,et al. AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis , 2003, Antimicrobial Agents and Chemotherapy.
[290] H. Wexler,et al. Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates. , 2006, The Journal of antimicrobial chemotherapy.
[291] B. Weisblum,et al. Erythromycin-Inducible Resistance in Staphylococcus aureus: Requirements for Induction , 1971, Journal of bacteriology.
[292] A. de Kruif,et al. tet(L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates. , 2005, The Journal of antimicrobial chemotherapy.
[293] T. Tsuchiya,et al. Functional gene cloning and characterization of the SsmE multidrug efflux pump from Serratia marcescens. , 2008, Biological & pharmaceutical bulletin.
[294] I. Wiegand,et al. Resistance Mechanisms of Multiresistant Pseudomonas aeruginosa Strains from Germany and Correlation with Hypermutation , 2007, Antimicrobial Agents and Chemotherapy.
[295] W. Kern,et al. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). , 2007, The Journal of antimicrobial chemotherapy.
[296] P. Plésiat,et al. Mechanisms of beta-lactam resistance in Pseudomonas aeruginosa: prevalence of OprM-overproducing strains in a French multicentre study (1997). , 2002, The Journal of antimicrobial chemotherapy.
[297] S. Mitsuhashi,et al. Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa , 1994, Antimicrobial Agents and Chemotherapy.
[298] P. Bradford,et al. AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii , 2005, Antimicrobial Agents and Chemotherapy.
[299] C. Gualerzi,et al. Review on Bacterial Stress Topics , 2007, Annals of the New York Academy of Sciences.
[300] B. Weisblum,et al. Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae , 1988, Journal of bacteriology.
[301] W. Rutala,et al. Use of Germicides in the Home and the Healthcare Setting Is There a Relationship Between Germicide Use and Antibiotic Resistance? , 2006, Infection Control & Hospital Epidemiology.
[302] Effect and Mechanism of Andrographolide on the Recovery of Pseudomonas aeruginosa Susceptibility to Several Antibiotics , 2008, The Journal of international medical research.
[303] J. Pagés,et al. The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli , 2004, Antimicrobial Agents and Chemotherapy.
[304] F. Mégraud,et al. Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. , 2006, Microbes and infection.
[305] Q. C. Truong-Bolduc,et al. DX-619, a Novel Des-Fluoro(6) Quinolone Manifesting Low Frequency of Selection of Resistant Staphylococcus aureus Mutants: Quinolone Resistance beyond Modification of Type II Topoisomerases , 2005, Antimicrobial Agents and Chemotherapy.
[306] S. Magnet,et al. AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii , 2008, Antimicrobial Agents and Chemotherapy.
[307] H. Zgurskaya,et al. Fitting Periplasmic Membrane Fusion Proteins to Inner Membrane Transporters: Mutations That Enable Escherichia coli AcrA To Function with Pseudomonas aeruginosa MexB , 2007, Journal of bacteriology.
[308] H. Nikaido,et al. Contributions of MexAB-OprM and an EmrE Homolog to Intrinsic Resistance of Pseudomonas aeruginosa to Aminoglycosides and Dyes , 2003, Antimicrobial Agents and Chemotherapy.
[309] Hilde Kruse,et al. Triclosan and antimicrobial resistance in bacteria: an overview. , 2006, Microbial drug resistance.
[310] D. Landman,et al. Correlation of Antimicrobial Resistance with β-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City , 2008, Antimicrobial Agents and Chemotherapy.
[311] E. Bokma,et al. Interactions underlying assembly of the Escherichia coli AcrAB–TolC multidrug efflux system , 2004, Molecular microbiology.
[312] Anil Kumar Singh,et al. Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. , 2008, Journal of medical microbiology.
[313] J. Chen,et al. Molecular Cloning and Characterization of an ABC Multidrug Efflux Pump, VcaM, in Non-O1 Vibrio cholerae , 2003, Antimicrobial Agents and Chemotherapy.
[314] R. Leclercq,et al. Resistance to Macrolides and Related Antibiotics in Streptococcus pneumoniae , 2002, Antimicrobial Agents and Chemotherapy.
[315] L. Bastide,et al. A multiwell assay to isolate compounds inhibiting the assembly of the prokaryotic RNA polymerase. , 2004, Assay and drug development technologies.
[316] S. Murakami,et al. Multidrug efflux transporter, AcrB--the pumping mechanism. , 2008, Current opinion in structural biology.
[317] M. Page,et al. Involvement of the Putative ATP-Dependent Efflux Proteins PatA and PatB in Fluoroquinolone Resistance of a Multidrug-Resistant Mutant of Streptococcus pneumoniae , 2006, Antimicrobial Agents and Chemotherapy.
[318] S. Tsiodras,et al. Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era. , 2008, Diagnostic microbiology and infectious disease.
[319] D. Clewell,et al. Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis , 1985, Journal of bacteriology.
[320] K. Diederichs,et al. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance. , 2008, Current drug targets.
[321] A. Holck,et al. Cross‐resistance to antibiotics of Escherichia coli adapted to benzalkonium chloride or exposed to stress‐inducers , 2004, Journal of applied microbiology.
[322] F. Sharom. ABC multidrug transporters: structure, function and role in chemoresistance. , 2008, Pharmacogenomics.
[323] Jun Lin,et al. Bile Salts Modulate Expression of the CmeABC Multidrug Efflux Pump in Campylobacter jejuni , 2005, Journal of bacteriology.
[324] J. Mekalanos,et al. Characterization of the Vibrio cholerae vexAB and vexCD efflux systems , 2006, Archives of Microbiology.
[325] E. Bokma,et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps , 2007, Proceedings of the National Academy of Sciences.
[326] L. Piddock,et al. The AcrAB–TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis , 2006, Cellular microbiology.
[327] T. Tsukihara,et al. Crystal Structure of the Membrane Fusion Protein, MexA, of the Multidrug Transporter in Pseudomonas aeruginosa* , 2004, Journal of Biological Chemistry.
[328] Ying Ying Chan,et al. Synergistic Interaction between Phenothiazines and Antimicrobial Agents against Burkholderia pseudomallei , 2006, Antimicrobial Agents and Chemotherapy.
[329] T. Tsuchiya,et al. VmeAB, an RND-type multidrug efflux transporter in Vibrio parahaemolyticus. , 2007, Microbiology.
[330] J. Pagés,et al. Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. , 2006, Recent patents on anti-infective drug discovery.
[331] T. Steitz,et al. The structural basis of ribosome activity in peptide bond synthesis. , 2000, Science.
[332] K. Poole,et al. Induction of the MexXY Efflux Pump in Pseudomonas aeruginosa Is Dependent on Drug-Ribosome Interaction , 2005, Journal of bacteriology.
[333] A. Yamaguchi,et al. AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals , 2008, Journal of Biological Chemistry.
[334] L. Piddock. Multidrug-resistance efflux pumps ? not just for resistance , 2006, Nature Reviews Microbiology.
[335] M. Dudley,et al. Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa. , 2003, Bioorganic & medicinal chemistry letters.
[336] D. Hocquet,et al. Antibiotic susceptibility and mechanisms of beta-lactam resistance among clinical strains of Pseudomonas aeruginosa: first report in Algeria. , 2008, Medecine et maladies infectieuses.
[337] D. Ceccarelli,et al. New Cluster of Plasmid-Located Class 1 Integrons in Vibrio cholerae O1 and a dfrA15 Cassette-Containing Integron in Vibrio parahaemolyticus Isolated in Angola , 2006, Antimicrobial Agents and Chemotherapy.
[338] W. Shafer,et al. Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae. , 2001, The Journal of antimicrobial chemotherapy.
[339] K. Poole,et al. Interaction of the MexA and MexB Components of the MexAB-OprM Multidrug Efflux System of Pseudomonas aeruginosa: Identification of MexA Extragenic Suppressors of a T578I Mutation in MexB , 2005, Antimicrobial Agents and Chemotherapy.
[340] K. Kimura,et al. New Plasmid-Mediated Fluoroquinolone Efflux Pump, QepA, Found in an Escherichia coli Clinical Isolate , 2007, Antimicrobial Agents and Chemotherapy.
[341] P. McDermott,et al. Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli , 2005, Antimicrobial Agents and Chemotherapy.
[342] D. Paterson,et al. Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii , 2007, Antimicrobial Agents and Chemotherapy.
[343] J. Menninger. Functional consequences of binding macrolides to ribosomes. , 1985, The Journal of antimicrobial chemotherapy.
[344] L. Piddock,et al. Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals. , 2003, The Journal of antimicrobial chemotherapy.
[345] T. Tsuchiya,et al. Gene cloning and characterization of KdeA, a multidrug efflux pump from Klebsiella pneumoniae. , 2007, Biological & pharmaceutical bulletin.
[346] A. Goesmann,et al. The 79,370-bp conjugative plasmid pB4 consists of an IncP-1β backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene blaNPS-1, and a tripartite antibiotic efflux system of the resistance-nodulation-division family , 2003, Molecular Genetics and Genomics.
[347] A. Oliver,et al. Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Pseudomonas aeruginosa Isolates from Spanish Hospitals , 2007, Antimicrobial Agents and Chemotherapy.
[348] T. Köhler,et al. Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa , 1999, Journal of bacteriology.
[349] A. Alonso,et al. Cloning and Characterization of SmeDEF, a Novel Multidrug Efflux Pump from Stenotrophomonas maltophilia , 2000, Antimicrobial Agents and Chemotherapy.
[350] J. Vázquez,et al. Fluoroquinolone resistance in Neisseria meningitidis in Spain. , 2007, The Journal of antimicrobial chemotherapy.
[351] J. Vincent,et al. Molecular Characterization of an Epidemic Clone of Panantibiotic-Resistant Pseudomonas aeruginosa , 2005, Journal of Clinical Microbiology.
[352] J. Navas,et al. Distribution of Tetracycline Resistance Genes in Actinobacillus pleuropneumoniae Isolates from Spain , 2006, Antimicrobial Agents and Chemotherapy.
[353] G. Kaatz,et al. Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus. , 2003, International journal of antimicrobial agents.
[354] P. Butaye,et al. Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria. , 2003, International journal of antimicrobial agents.
[355] G. Kaatz,et al. Identification and characterization of a novel efflux-related multidrug resistance phenotype in Staphylococcus aureus. , 2002, The Journal of antimicrobial chemotherapy.
[356] I. Paulsen,et al. Proton-dependent multidrug efflux systems , 1996, Microbiological reviews.
[357] K. Poole,et al. Assembly of the MexAB-OprM Multidrug Efflux System of Pseudomonas aeruginosa: Identification and Characterization of Mutations in mexA Compromising MexA Multimerization and Interaction with MexB , 2004, Journal of bacteriology.
[358] E C Cole,et al. Investigation of antibiotic and antibacterial agent cross‐resistance in target bacteria from homes of antibacterial product users and nonusers , 2003, Journal of applied microbiology.
[359] G. Riccardi,et al. mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis , 2005, Antimicrobial Agents and Chemotherapy.
[360] P. Bradford,et al. RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. , 2007, Microbial drug resistance.
[361] M. Roberts,et al. Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. , 2008, FEMS microbiology letters.
[362] E. Cundliffe,et al. Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae. , 1991, Gene.
[363] A. Yamaguchi,et al. Analysis of a Complete Library of Putative Drug Transporter Genes in Escherichia coli , 2001, Journal of bacteriology.
[364] D. Dubnau,et al. Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus , 1987, Journal of bacteriology.
[365] M. Webber,et al. Prolonged treatment of Salmonella enterica serovar Typhimurium with commercial disinfectants selects for multiple antibiotic resistance, increased efflux and reduced invasiveness. , 2007, The Journal of antimicrobial chemotherapy.
[366] M. Ehrenberg,et al. Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin. , 2009, Biochimie.
[367] G. Cornaglia,et al. AcrAB Efflux System: Expression and Contribution to Fluoroquinolone Resistance in Klebsiella spp , 2002, Antimicrobial Agents and Chemotherapy.
[368] Mark A. Miller,et al. The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice. , 2008, FEMS microbiology letters.
[369] D. Livermore,et al. Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection Potential , 2004, Antimicrobial Agents and Chemotherapy.
[370] D. Dubnau,et al. An in vitro study of the translational attenuation model of ermC regulation. , 1987, The Journal of biological chemistry.
[371] Y. Li,et al. A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa. , 2003, The Journal of antimicrobial chemotherapy.
[372] Lori A. S. Snyder,et al. A Gonococcal Efflux Pump System Enhances Bacterial Survival in a Female Mouse Model of Genital Tract Infection , 2003, Infection and Immunity.
[373] J. Martínez,et al. The Biocide Triclosan Selects Stenotrophomonas maltophilia Mutants That Overproduce the SmeDEF Multidrug Efflux Pump , 2005, Antimicrobial Agents and Chemotherapy.
[374] Ayush Kumar,et al. Cloning, Sequencing, and Characterization of the SdeAB Multidrug Efflux Pump of Serratia marcescens , 2005, Antimicrobial Agents and Chemotherapy.
[375] M. Jacobs,et al. In Vitro Activity of the New Quinolone WCK 771 against Staphylococci , 2004, Antimicrobial Agents and Chemotherapy.
[376] M. Maurel,et al. Regulation of the expression of the CmeABC efflux pump in Campylobacter jejuni: identification of a point mutation abolishing the binding of the CmeR repressor in an in vitro-selected multidrug-resistant mutant. , 2007, FEMS microbiology letters.
[377] M. Kalin,et al. Cefuroxime non-susceptibility in multidrug-resistant Klebsiella pneumoniae overexpressing ramA and acrA and expressing ompK35 at reduced levels. , 2008, The Journal of antimicrobial chemotherapy.
[378] R. Wallace,,et al. A Novel Gene, erm(41), Confers Inducible Macrolide Resistance to Clinical Isolates of Mycobacterium abscessus but Is Absent from Mycobacterium chelonae , 2008, Antimicrobial Agents and Chemotherapy.
[379] M. C. Moken,et al. Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci , 1997, Antimicrobial agents and chemotherapy.
[380] Gregor Blaha,et al. Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance , 2005, Cell.
[381] G. Kaatz,et al. Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps. , 2008, European journal of medicinal chemistry.
[382] Masato Yoshimura,et al. Crystal Structure of the Drug Discharge Outer Membrane Protein, OprM, of Pseudomonas aeruginosa , 2004, Journal of Biological Chemistry.
[383] W. Ludwig,et al. Plasmid-borne macrolide resistance in Micrococcus luteus. , 2002, Microbiology.
[384] B. Weisblum,et al. Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis , 1991, Journal of bacteriology.
[385] T. Tsuchiya,et al. Properties and expression of a multidrug efflux pump AcrAB-KocC from Klebsiella pneumoniae. , 2008, Biological & pharmaceutical bulletin.
[386] T. Gootz,et al. Genetic and Molecular Characterization of β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin , 2004, Antimicrobial Agents and Chemotherapy.
[387] K. Marotti,et al. 3-Arylpiperidines as potentiators of existing antibacterial agents. , 2001, Bioorganic & medicinal chemistry letters.
[388] D. Paterson,et al. Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. , 2006, The Journal of antimicrobial chemotherapy.
[389] S. Schwarz,et al. Molecular mechanisms of decreased susceptibility to fluoroquinolones in avian Salmonella serovars and their mutants selected during the determination of mutant prevention concentrations. , 2007, The Journal of antimicrobial chemotherapy.
[390] J. Martínez,et al. The efflux pump inhibitor Phe-Arg-beta-naphthylamide does not abolish the activity of the Stenotrophomonas maltophilia SmeDEF multidrug efflux pump. , 2003, The Journal of antimicrobial chemotherapy.
[391] S. Schwarz,et al. Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet. , 2007, International journal of antimicrobial agents.
[392] R. Hancock,et al. Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids , 1999, Antimicrobial Agents and Chemotherapy.
[393] A. Alonso,et al. Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa. , 1999, Microbiology.
[394] R. Cantón,et al. Regional trends in beta-lactam, macrolide, fluoroquinolone and telithromycin resistance among Streptococcus pneumoniae isolates 2001-2004. , 2007, The Journal of infection.
[395] G. Drusano,et al. Isoniazid's bactericidal activity ceases because of the emergence of resistance, not depletion of Mycobacterium tuberculosis in the log phase of growth. , 2007, The Journal of infectious diseases.
[396] K. Poole. Bacterial Multidrug Efflux Pumps Serve Other Functions , 2008 .
[397] J. Pagés,et al. Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates. , 2006, International journal of antimicrobial agents.
[398] S. Schwarz,et al. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. , 2004, FEMS microbiology reviews.
[399] K. Poole,et al. Can efflux inhibitors really counter resistance , 2006 .
[400] K. Poole,et al. Contribution of the MexXY Multidrug Transporter to Aminoglycoside Resistance in Pseudomonas aeruginosa Clinical Isolates , 2003, Antimicrobial Agents and Chemotherapy.
[401] J. Chen,et al. Molecular cloning and characterization of a multidrug efflux pump, SmfY, from Serratia marcescens. , 2007, Biological & pharmaceutical bulletin.
[402] C. Elkins,et al. Chimeric Analysis of AcrA Function Reveals the Importance of Its C-Terminal Domain in Its Interaction with the AcrB Multidrug Efflux Pump , 2003, Journal of bacteriology.
[403] Isabella Moll,et al. Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs. , 2004, Nucleic acids research.
[404] K. Diederichs,et al. Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism , 2006, Science.
[405] M. Roberts. Distribution of macrolide, lincosamide, streptogramin, ketolide and oxazolidinone (MLSKO) resistance genes in Gram-negative bacteria. , 2004, Current drug targets. Infectious disorders.
[406] Claude Carbón,et al. Differential Selection of Multidrug Efflux Mutants by Trovafloxacin and Ciprofloxacin in an Experimental Model ofPseudomonas aeruginosa Acute Pneumonia in Rats , 2001, Antimicrobial Agents and Chemotherapy.
[407] M. Roberts. Update on acquired tetracycline resistance genes. , 2005, FEMS microbiology letters.
[408] K. Köhrer,et al. Structural Alterations in the Translational Attenuator of Constitutively Expressed erm(A) Genes inStaphylococcus aureus , 2001, Antimicrobial Agents and Chemotherapy.
[409] T. Tsuchiya,et al. SmdAB, a Heterodimeric ABC-Type Multidrug Efflux Pump, in Serratia marcescens , 2007, Journal of bacteriology.
[410] K. Reich,et al. Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. , 1999, Microbial drug resistance.
[411] E. Houang,et al. Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. , 2006, Journal of medical microbiology.
[412] K. Poole. Uninhibited antibiotic target discovery via chemical genetics , 2004, Nature Biotechnology.
[413] A. Mankin,et al. Molecular mechanism of drug-dependent ribosome stalling. , 2008, Molecular cell.
[414] T. Tsuchiya,et al. Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1. , 2003, The Journal of antimicrobial chemotherapy.
[415] G. Manina,et al. Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome , 2006, BMC Microbiology.
[416] C. Arias,et al. Characterization of macrolide resistance in Gram-positive cocci from Colombian hospitals: a countrywide surveillance. , 2007, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
[417] H. Ramu,et al. Programmed drug‐dependent ribosome stalling , 2009, Molecular microbiology.
[418] Georgios S. Vernikos,et al. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants , 2008, Genome Biology.
[419] O. Sahin,et al. Critical Role of Multidrug Efflux Pump CmeABC in Bile Resistance and In Vivo Colonization of Campylobacter jejuni , 2003, Infection and Immunity.
[420] W. Konings,et al. Multidrug transporters and antibiotic resistance in Lactococcus lactis. , 2002, Biochimica et biophysica acta.
[421] F. Yoshimura,et al. Sixteen Homologs of the Mex-Type Multidrug Resistance Efflux Pump in Bacteroides fragilis , 2005, Antimicrobial Agents and Chemotherapy.
[422] S. Fanning,et al. Antimicrobial resistance in foodborne pathogens--a cause for concern? , 2008, Current drug targets.
[423] J. Basu,et al. Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. , 2002, The Biochemical journal.
[424] E. Worobec,et al. The role of the Serratia marcescens SdeAB multidrug efflux pump and TolC homologue in fluoroquinolone resistance studied via gene-knockout mutagenesis. , 2008, Microbiology.
[425] E. Brown,et al. Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. , 2004, Chemistry & biology.
[426] C. King,et al. Novel Tetracycline Resistance Determinant Isolated from an Environmental Strain of Serratia marcescens , 2007, Applied and Environmental Microbiology.
[427] V. Tam,et al. Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa. , 2007, Diagnostic microbiology and infectious disease.
[428] Måns Ehrenberg,et al. The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. , 2003, Journal of molecular biology.
[429] F. Kong,et al. Three New Macrolide Efflux (mef) Gene Variants in Streptococcus agalactiae , 2007, Journal of Clinical Microbiology.
[430] N. Gotoh,et al. Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa , 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
[431] M. Braoudaki,et al. Adaptive Resistance to Biocides in Salmonella enterica and Escherichia coli O157 and Cross-Resistance to Antimicrobial Agents , 2004, Journal of Clinical Microbiology.
[432] Jennifer L. Groh,et al. Genes That Enhance the Ecological Fitness of Shewanella oneidensis MR-1 in Sediments Reveal the Value of Antibiotic Resistance , 2006, Applied and Environmental Microbiology.
[433] D. Ince,et al. Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Garenoxacin (BMS-284756, T-3811ME), a New Desfluoroquinolone , 2002, Antimicrobial Agents and Chemotherapy.
[434] S. Payot,et al. Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli. , 2004, International journal of antimicrobial agents.